Search results for "Base"

Low-loading asymmetric organocatalysis

2011

Asymmetric organocatalysis is now recognized as the third pillar of asymmetric synthesis. Recent years have witnessed increasing interest towards the use of highly active and stereoselective organocatalysts. This critical review documents the advances in the development of chiral organocatalysts which are systematically used in ≤3 mol% loading in all the sub-areas of the field, namely aminocatalysis, Brønsted acids and bases, Lewis acids and bases, hydrogen bond-mediated catalysis, phase transfer and N-heterocyclic carbene catalyses (194 references).

Synthesis and biological activities of a new class of heat shock protein 90 inhibitors, designed by energy-based pharmacophore virtual screening

2013

The design through energy-based pharmacophore virtual screening has led to aminocyanopyridine derivatives as efficacious new inhibitors of Hsp90. The synthesized compounds showed a good affinity for the Hsp90 ATP binding site in the competitive binding assay. Moreover, they showed an excellent antiproliferative activity against a large number of human tumor cell lines. Further biological studies on the derivative with the higher EC50 confirmed its specific influence on the cellular pathways involving Hsp90.

Un escarpement sous-marin permanent du Lias à l'Eocène, dans la dorsale calcaire Péloritaine (Sicile, Italie)

1999

The schistosity of the Palaeozoic basement of the Capo San Andrea unit (Peloritan Dorsale) is cut by Liassic to Eocene neptunian dykes which developed along a pelagic fault scarp exposed on the sea bottom for 140 My. The Mesozoic structures determined the location of the Alpine deformation.

Lo bueno, si breve, dos veces bueno a veces

2007

Los bebedores pueden distribuirse dentro de un continuum, de acuerdo con su nivel de riesgo y problemas. Las intervenciones deberían distribuirse y administrarse también sin solución de continuidad, incluyendo desde la prevención hasta la rehabilitación.La intervención breve es una de las mejores estrategias para reducir la carga morbosa del alcohol; por otra parte, los pacientes dependientes deberían ser tratados con intervenciones amplias y personalizadas con años de seguimiento. Breve y extenso al mismo tiempo, ¿es una contradicción?Se presenta una reflexión en torno a la ampliación de la base del tratamiento y la necesidad de identificar las dimensiones psíquica , física y social dentro…

Oligonucleotides in Sensing and Diagnostic Applications

2015

Plasmonic Nanosensor Array for Multiplexed DNA-based Pathogen Detection

2019

In this research we introduce a plasmonic nanoparticle based optical biosensor for monitoring of molecular binding events. The sensor utilizes spotted gold nanoparticle arrays as sensing platform. The nanoparticle spots are functionalized with capture DNA sequences complementary to the analyte (target) DNA. Upon incubation with the target sequence, it will bind on the respectively complementary functionalized particle spot. This binding changes the local refractive index, which is detected spectroscopically as the resulting changes of the localized surface plasmon resonance (LSPR) peak wavelength. In order to increase the signal, a small gold nanoparticle label is introduced. The binding ca…

Science based calibration for the extraction of 'analyte-specific' HPLC-DAD chromatograms in environmental analysis

2010

Multivariate science based calibration (SBC) has been applied to the resolution of overlapped peaks in liquid chromatography with diode array detection (LC-DAD). Complex river water samples spiked with 11 pharmaceutical substances resulted in poorly resolved chromatograms containing additional peaks from interfering matrix compounds and a change in the background absorbance due to the mobile phase gradient. Applying the present multivariate approach it was possible to resolve all 11 analytes from overlapping peaks, obtaining linear calibration lines (R2 > 0.96). Recovery percentages on spiked samples ranged between 74.6 and 113.5%, which are quite satisfactory taking into account the low co…

The Transfer Function of Non-Stationary Indoor Channels and its Relationship to System Functions of LFMCW Radars

2021

This paper studies the relationship between the time-variant (TV) channel transfer function (CTF) of non-stationary indoor channels and the system functions of linear frequency modulated continuous waves (LFMCW) radars. To do so, we consider a moving person/object in indoor environments, which is modelled by a cluster of moving point scatterers. It is shown that the TVCTF can be obtained from the beat signal of LFMCW radar systems. Analytical expressions are derived for the TV demodulated radar response, the complex channel gain, and the TV Doppler-delay profile. A relationship between the presented results and existing non-stationary indoor channel models assuming pulsed wave systems is al…

Diversity of ankA and msp4 genes of Anaplasma phagocytophilum in Slovenia.

2015

Granulocytic anaplasmosis is a tick transmitted emerging disease in Europe and worldwide. The agent, Anaplasma phagocytophilum is transmitted by ticks of the genus Ixodes and causes infections in humans and domestic animals. The analysis of different target genes showed that in nature several genetic variants of A. phagocytophilum were present. The purpose of our study was to genetically characterize A. phagocytophilum strains from eight humans, 16 dogs, 12 wild boars, one bear and 18 tick pools from Slovenia. Therefore, the ankA and msp4 genes of A. phagocytophilum were chosen. The same genetic ankA and msp4 variant of A. phagocytophilum was detected in humans, wild boar and a part of the …

Changes in sprint performance and sagittal plane kinematics after heavy resisted sprint training in professional soccer players

2019

Background Sprint performance is an essential skill to target within soccer, which can be likely achieved with a variety of methods, including different on-field training options. One such method could be heavy resisted sprint training. However, the effects of such overload on sprint performance and the related kinetic changes are unknown in a professional setting. Another unknown factor is whether violating kinematic specificity via heavy resistance will lead to changes in unloaded sprinting kinematics. We investigated whether heavy resisted sled training (HS) affects sprint performance, kinetics, sagittal plane kinematics, and spatiotemporal parameters in professional male soccer players.…