Search results for "C2"
showing 10 items of 879 documents
Melanokortīna otrā tipa receptora un tā palīgproteīna ekspresija rauga Pichia Pastoris ekspresijas sistēmā
2015
Darba ietvaros tika izveidots pPIC9K- MC2R-T4L ekspresijas konstrukts, kas tika ekspresēts P.Pastoris sistēmā. Western blot analīze uzrādīja nepieciešamās molekulmasas zonu. MC2R-T4L izdevās attīrīt uz His- un Ha-tag afinitātes kolonnām. Lai noteiktu funkcionāla MC2R struktūru, to nepiecieciešams ekspresēt kompleksā ar MRAP, tādēļ tika izveidoti vairāki MC2-MRAP konstrukti, ko tālāk izmantot proteīna ekspresijai P. Pastoris šūnās. To aktivitāte tika pārbaudīta zīdītāju šūnu līnijās nosakot cAMP daudzuma izmaiņas pēc stimulācijas ar ACTH (1-24). Iegūtie rezultāti bija nestabili, tādēļ tālākajos pētījumos tiks veikta radioaktīvā ACTH saistīšanas mērījumus. Darbs tika veikts no 2013.gada jūnij…
Analysis of the determinants of entrepreneurial intention: the case of Burkina Faso
2018
International audience; In this study, we propose to analyze students' entrepreneurial intention, drawing on Lazear's (2004) self-selection model. This model captures the role of "human capital" in employment assignment and emphasizes the importance of the variety of skills in the individual's entrepreneurial orientation. For this purpose, we have a database collected in 2017 from over 1000 students at Ouaga I and Ouaga II universities in Burkina Faso. The results of estimates obtained using the quantile regression method show a positive and significant effect of the diversity of skills on the intention score, mainly at the median level. Even if the effect is not strong, this result support…
Value of Combined PET Imaging with [18F]FDG and [68Ga]Ga-PSMA-11 in mCRPC Patients with Worsening Disease during [177Lu]Lu-PSMA-617 RLT
2021
Despite the promising results of prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) in metastatic castration-resistant prostate cancer (mCRPC), some patients show worsening disease during PSMA-RLT. We investigated the value of combined [18F]FDG and [68Ga]Ga-PSMA-11 PET imaging in this setting. In n = 29 mCRPC patients with worsening disease after a median of four cycles of [177Lu]Lu-PSMA-617 RLT, combined [18F]FDG and [68Ga]Ga-PSMA-11 PET imaging was performed to detect [18F]FDG-avid lesions with low or no PSMA expression (mismatch lesions). To evaluate prognostic implication of mismatch, survival analyses regarding presence, location, and [18F]FDG PET-derived para…
Structured reporting of rectal cancer staging and restaging: A consensus proposal
2021
Background: Structured reporting (SR) in oncologic imaging is becoming necessary and has recently been recognized by major scientific societies. The aim of this study was to build MRI-based structured reports for rectal cancer (RC) staging and restaging in order to provide clinicians all critical tumor information. Materials and Methods: A panel of radiologist experts in abdominal imaging, called the members of the Italian Society of Medical and Interventional Radiology, was established. The modified Delphi process was used to build the SR and to assess the level of agreement in all sections. The Cronbach’s alpha (Cα) correlation coefficient was used to assess the internal consistency of ea…
Oxidative and nitrosative stress in the metastatic microenvironment.
2010
Metastases that are resistant to conventional therapies are the main cause of most cancer-related deaths in humans. Tumor cell heterogeneity, which associates with genomic and phenotypic instability, represents a major problem for cancer therapy. Additional factors, such as the attack of immune cells or organ-specific microenvironments, also influence metastatic cell behavior and the response to therapy. Interaction of cancer and endothelial cells in capillary beds, involving mechanical contact and transient adhesion, is a critical step in the initiation of metastasis. This interaction initiates a cascade of activation pathways that involves cytokines, growth factors, bioactive lipids and r…
Acoustic wave guides as infinite-dimensional dynamical systems
2015
We prove the unique solvability, passivity/conservativity and some regularity results of two mathematical models for acoustic wave propagation in curved, variable diameter tubular structures of finite length. The first of the models is the generalised Webster's model that includes dissipation and curvature of the 1D waveguide. The second model is the scattering passive, boundary controlled wave equation on 3D waveguides. The two models are treated in an unified fashion so that the results on the wave equation reduce to the corresponding results of approximating Webster's model at the limit of vanishing waveguide intersection.
Assessment of Sentinel-2-MSI Atmospheric Correction Processors and In Situ Spectrometry Waters Quality Algorithms
2022
The validation of algorithms developed from in situ reflectance to estimate water quality variables has the challenge of atmospheric correction (AC) when applied to satellite images. Estimating water quality variables from satellite images requires an accurate estimation of remote sensing reflectances (Rrs) which vary according to the AC applied. Validation processes for both Rrs and water quality algorithms were carried out, relating the in situ Rrs (convoluted to Sentinel-2-MSI spectral response function) with the satellite Rrs coming from different ACs (C2RCC, C2X, C2XC, and Polymer), and also relating the in situ water quality variable data with estimated water quality variable values, …
Kinetics of Renal Function during Induction in Newly Diagnosed Multiple Myeloma: Results of Two Prospective Studies by the German Myeloma Study Group…
2021
Background: Preservation of kidney function in newly diagnosed (ND) multiple myeloma (MM) helps to prevent excess toxicity. Patients (pts) from two prospective trials were analyzed, provided postinduction (PInd) restaging was performed. Pts received three cycles with bortezomib (btz), cyclophosphamide, and dexamethasone (dex
Muscle and serum metabolomes are dysregulated in colon-26 tumor-bearing mice despite amelioration of cachexia with activin receptor type 2B ligand bl…
2019
Cancer-associated cachexia reduces survival, which has been attenuated by blocking the activin receptor type 2B (ACVR2B) ligands in mice. The purpose of this study was to unravel the underlying physiology and novel cachexia biomarkers by use of the colon-26 (C26) carcinoma model of cancer cachexia. Male BALB/c mice were subcutaneously inoculated with C26 cancer cells or vehicle control. Tumor-bearing mice were treated with vehicle (C26+PBS) or soluble ACVR2B either before (C26+sACVR/b) or before and after (C26+sACVR/c) tumor formation. Skeletal muscle and serum metabolomics analysis was conducted by gas chromatography-mass spectrometry. Cancer altered various biologically functional groups …
An Examination of Tourist Arrivals Dynamics Using Short-Term Time Series Data: A Space—Time Cluster Approach
2013
The purpose of this study is to examine the development of Italian tourist areas ( circoscrizioni turistiche) through a cluster analysis of short time series. The technique is an adaptation of the functional data analysis approach developed by Abraham et al (2003), which combines spline interpolation with k-means clustering. The findings indicate the presence of two patterns (increasing and stable) averagely characterizing groups of territories. Moreover, tests of spatial contiguity suggest the presence of ‘space–time clusters’; that is, areas in the same ‘time cluster’ are also spatially contiguous. These findings appear to be more robust in particular for those series characterized by an…