Search results for "CAE"
showing 10 items of 601 documents
Bruton tyrosine kinase-like protein, BtkSD, is present in the marine sponge Suberites domuncula.
2003
Sponges, the simplest and most ancient phylum of Metazoa, encode in their genome complex and highly sophisticated proteins that evolved together with multicellularity and are found only in metazoan animals. We report here the finding of a Bruton tyrosine kinase (BTK)-like protein in the marine sponge Suberites domuncula (Demospongiae). The nucleotide sequence of one sponge cDNA predicts a 700-aa-long protein, which contains all of the characteristic domains for the Tec family of protein tyrosine kinases (PTKs). The highest homology (38% identity, 55% overall similarity) was found with human BTK and TEC PTKs. Sponge PTK was therefore named BtkSD. Human BTK is involved in the maturation of B …
Molecular mechanisms in developmental biology.
1996
Some general molecular mechanisms underlying development are described. Namely: those involved in the differentiation of the R7 receptor in Drosophila embryonic retina; those involved in the determination of embryonic axes and in polar cell differentiation, in Drosophila; those involved in the determination of the AB and P cell lineage and in vulva differentiation in Caenorhabditis embryos.
Gallia est omnis divisa in partes tres.. : -tutkimus Gaius Julius Caesarin Commentarii de bello Gallico -teoksen Gallia Transalpinan heimonimistä ja …
1999
Caesarin Gallian sota -teos toi aikalaistensa tietoisuuteen sen ajan mittapuun mukaan valtavan maa-alueen asukkaineen ja maantieteellisine nimistöineen, mikä tekeekin siitä erinomaisen lähteen nimistön tutkimukseen. Tutkimuksessani kartoitan Gallian sota -teoksessa esiintyvät Gallia Transalpinan heimonimet, paikkakunnan nimet, vesistöjen nimet ja muut maantieteelliset nimet, sekä tutkin näiden nimien säilyvyyttä nykynimistössä ja tekstikriittisesti epävarmojen nimien esiintyvyyttä. Caesar mainitsee Gallia Transalpinan alueelta 94 heimoa, 32 paikkakuntaa, 13 vesistöä ja kuusi muuta maantieteellistä nimeä. Näistä nimistä on säilynyt lähes 58% nykypäivään asti alueen nykyvaltioiden maantieteel…
Sigma-1 Receptor Activation Induces Autophagy and Increases Proteostasis Capacity In Vitro and In Vivo
2019
Dysfunction of autophagy and disturbed protein homeostasis are linked to the pathogenesis of human neurodegenerative diseases and the modulation of autophagy as the protein clearance process has become one key pharmacological target. Due to the role of sigma-1 receptors (Sig-1R) in learning and memory, and the described pleiotropic neuroprotective effects in various experimental paradigms, Sig-1R activation is recognized as one potential approach for prevention and therapy of neurodegeneration and, interestingly, in amyotrophic lateral sclerosis associated with mutated Sig-1R, autophagy is disturbed. Here we analyzed the effects of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hyd…
The deubiquitinase USP11 is a versatile and conserved regulator of autophagy
2021
Autophagy is a major cellular quality control system responsible for the degradation of proteins and organelles in response to stress and damage to maintain homeostasis. Ubiquitination of autophagy-related proteins or regulatory components is important for the precise control of autophagy pathways. Here, we show that the deubiquitinase ubiquitin-specific protease 11 (USP11) restricts autophagy and that KO of USP11 in mammalian cells results in elevated autophagic flux. We also demonstrate that depletion of the USP11 homolog H34C03.2 in Caenorhabditis elegans triggers hyperactivation of autophagy and protects the animals against human amyloid-β peptide 42 aggregation-induced paralysis. USP11…
Effects of Rosmarinus officinalis and Salvia officinalis essential oils on Tetranychus urticae Koch (Acari: Tetranychidae)
2013
Laboratory trials were carried out to characterize Rosmarinus officinal and Salvia officinalis essential oils and to evaluate their pesticidal activities against Tetranychus urticae. Slide-dip and leaf-disk bioassays were employed to study the mortality caused by these plant oils on two-spotted spiders. Different dilutions of both essential oils (0.10-0.25%, v/v) caused acute contact toxicity, although the sage extract showed greater acaricidal activity than rosemary oil. Mortality rates of 95-100% were observed at all the sage oil dosages and when rosemary emulsions contained at least 0.20% of essential oil. In the residual contact experiments (leaf-disk assays), 0.15-0.25% of sage oil or …
New species, records and synonymies of West Palaearctic Pamphaginae (Orthoptera: Caelifera: Pamphagidae)
2012
The author analyses the species of some West Palaearctic genera of Pamphaginae, namely Euryparyphes, Paraeuryparyphes, Glauia, Pseudoglauia, Glauvarovia, Prionosthenus, Lativertex, Ocnerosthenus, establishing the following synonymies: Euryparyphes olcesei (Bolivar 1907) = Euryparyphes bolivari (Stål 1876); Euryparyphes paraflexuosus La Greca 1993 = Euryparyphes flexuosus Uvarov 1927; Glauia durieui rubripes Morales Agacino & Descamps 1968 = Glauia durieui durieui (Bolivar 1878); Prionosthenus lebanicus Dirsh 1950 = Prionosthenus femoralis Werner 1938; Prionosthenus (Lativertex) Koçak & Kemal 2011 = Paranothrotes Mishchenko 1951. Further, the author confirms the synonymies: Euryparyphes vauc…
Exploitation competition between hole‐nesters ( Muscardinus avellanarius , Mammalia and Parus caeruleus , Aves) in Mediterranean woodlands
2005
Data from a long-term study (1993-2003) using artificial nest-boxes, were analysed to examine competition for nesting between blue tit Parus caeruleus and common dormouse Muscardinus avellanarius in Sicily. Occupation rates and the reproductive biology of the blue tit in sample woodlots outside the distribution area of the common dormouse were used as a control in sample areas where the two species were syntopic. A selection test showed that the two species, when living in syntopy, actively chose the small nest-boxes, thus overlapping in the use of the same spatial resource. The experimental exclusion of the common dormouse from nest-boxes caused an increase of blue tit occupation rate. Onc…
The comparison of beta-thymosin homologues among metazoa supports an arthropod-nematode clade.
2000
The definition of an Ecdysozoa clade among the protostomians, including all phyla with a regularly molted alpha-chitin-rich cuticle, has been one of the most provocative hypotheses to arise from recent investigations on animal phylogeny. Here we present evidence in favor of an arthropod-nematode clade, from the comparison of beta-thymosin homologues among the Metazoa. Arthropods and nematodes share the absence of the highly conserved beta-thymosin form found in all other documented bilaterian phyla as well as sponges, and the possession of a very unusual, internally triplicated homologue of the beta-thymosin protein, unknown in other phyla. We argue that such discrete molecular character is…
Annotated Check-List of Orthoptera of Libya
2009
Abstract A list of Libyan Orthoptera is presented based on specimens preserved in Museums, incorporating all (previously published or unpublished) label information. Overall, 141 species are included, of which four are new records for the country. Given within “species inquirendae” are another six species, with the reasons for confirming their presence. Libya's orthopteran fauna is probably not rich, but our knowledge of it is far from exhaustive.