Search results for "CCR"
showing 10 items of 574 documents
CCL27 Signaling in the Tumor Microenvironment
2021
Chemokines are a group of small proteins which play an important role in leukocyte migration and invasion. They are also involved in the cellular proliferation and migration of tumor cells.Chemokine CCL27 (cutaneous T cell-attracting chemokine, CTACK) is mainly expressed by keratinocytes of the normal epidermis. It is well known that this chemokine plays an important role in several inflammatory diseases of the skin, such as atopic dermatitis, contact dermatitis, and psoriasis. Moreover, several studies have shown an association between CCL27 expression and a variety of neoplasms including skin cancer.In this chapter, we address the role of chemokine CCL27 in the tumor microenvironment in t…
Role of the chemokine decoy receptor D6 in balancing inflammation, immune activation, and antimicrobial resistance in Mycobacterium tuberculosis infe…
2008
D6 is a decoy and scavenger receptor for inflammatory CC chemokines. D6-deficient mice were rapidly killed by intranasal administration of low doses of Mycobacterium tuberculosis. The death of D6(-/-) mice was associated with a dramatic local and systemic inflammatory response with levels of M. tuberculosis colony-forming units similar to control D6-proficient mice. D6-deficient mice showed an increased numbers of mononuclear cells (macrophages, dendritic cells, and CD4 and CD8 T lymphocytes) infiltrating inflamed tissues and lymph nodes, as well as abnormal increased concentrations of CC chemokines (CCL2, CCL3, CCL4, and CCL5) and proinflammatory cytokines (tumor necrosis factor alpha, int…
Flaring activity on the disk of Classical T Tauri Stars: effects on disk stability
2018
Classical T Tauri Stars (CTTSs) are young stellar objects surrounded by a circumstellar disk with which they exchange mass and angular momentum through accretion. Despite this process is a crucial aspect of star formation, some issues are still not clear; in particular how the material loses angular momentum and falls into the star. CTTSs are also characterized by strong X-ray emission. Part of this X-ray emission comes from the heated plasma in the external regions of the stellar corona with temperature between 1 and 100 MK. The plasma heating is presumably due to the strong magnetic field (Feigelson and Montmerle, 1999) in the form of high energetic flares in proximity of the stellar surf…
Linear relationship between effective radius and precipitation water content near the top of convective clouds
2021
Quantifying the precipitation within clouds is a crucial challenge to improve our current understanding of the Earth’s hydrological cycle. We have investigated the relationship between the effective radius of droplets and ice particles (re) and precipitation water content (PWC) measured by cloud probes near the top of growing convective cumuli. The data for this study were collected by aircraft measurements in clean and polluted conditions over the Amazon Basin and over the western tropical Atlantic in September 2014. Our results indicate a threshold of re ∼ 13 μm for warm rain initiation in convective clouds, which is in agreement with previous studies. In…
Black hole-neutron star coalescence: effects of the neutron star spin on jet launching and dynamical ejecta mass
2020
Black hole-neutron star (BHNS) mergers are thought to be sources of gravitational waves (GWs) with coincident electromagnetic (EM) counterparts. To further probe whether these systems are viable progenitors of short gamma-ray bursts (sGRBs) and kilonovae, and how one may use (the lack of) EM counterparts associated with LIGO/Virgo candidate BHNS GW events to sharpen parameter estimation, we study the impact of neutron star spin in BHNS mergers. Using dynamical spacetime magnetohydrodynamic simulations of BHNSs initially on a quasicircular orbit, we survey configurations that differ in the BH spin ($a_{\rm BH}/M_{\rm BH}=0$ and $0.75$), the NS spin ($a_{\rm NS}/M_{\rm NS}=-0.17,\,0,\,0.23$ a…
Obstacles modelling reality: Two exploratory studies on physics defined and undefined problems
2014
For some researchers, and perhaps for many teachers, problem-solving is strongly related to thinking (Mayer, 1983). Several reports highlight the importance of developing suitable skills to solve complex, ill-defined and boundless real-life problems in educated people (NSF Standards, U.S. Department of Labour, ABET engineering accreditation organization, and American Institute of Physics, mentioned in Etkina & Van Heuvelen, 2007; Bureau of Labour Statistics, U.S. Department of Labour, 2014; Competency Model Clearinghouse, 2012). Problem-solving is virtually the core of the professional activity of a physicist (Etkina, Van Heuvelen, White-Brahmia, Brookes, Gentile, Murthy, Rosengrant & Warre…
Continuing Education in the Health Sciences in Spain
2008
<div class="ftSection"><span class="ftInlineSubsectionTitle">Background:</span><p>Employers have long been concerned about the professional qualifications of their employees. Decision makers in the health sciences are no exception, particularly now that they are seriously considering the improvement and full accreditation of continuing education as part of the planned European convergence.</p></div><div class="ftSection"><span class="ftInlineSubsectionTitle">Method:</span><p>Medical and nursing professionals were questioned about their views on continuing education, suitable content of possible programs, and implementation, in comp…
Weakening Forensic Science in Spain: From Expert Evidence to Documentary Evidence*
2012
An amendment in 2002 to the Spanish Code of Criminal Procedure converted into documentary evidence the expert reports prepared by official laboratories aimed at determining the nature, weight, and purity of seized drugs. In most cases, experts are spared from appearance before the courts. This is likely to be extended to other forensic fields. After an overview of criminalistic identification in current forensic science, the objectivity and reliability concepts used by jurists and scientists are considered by comparing the paradigm of individualization with that of likelihood. Subsequently, a detailed critical study is made on the above-mentioned Spanish legal reform, and a comparison is ma…
Three-Dimensional Core-Collapse Supernova Simulations with Multi-Dimensional Neutrino Transport Compared to the Ray-by-Ray-plus Approximation
2018
Self-consistent, time-dependent supernova (SN) simulations in three spatial dimensions (3D) are conducted with the Aenus-Alcar code, comparing, for the first time, calculations with fully multi-dimensional (FMD) neutrino transport and the ray-by-ray-plus (RbR+) approximation, both based on a two-moment solver with algebraic M1 closure. We find good agreement between 3D results with FMD and RbR+ transport for both tested grid resolutions in the cases of a 20 solar-mass progenitor, which does not explode with the employed simplified set of neutrino opacities, and of an exploding 9 solar-mass model. This is in stark contrast to corresponding axisymmetric (2D) simulations, which confirm previou…
Hacia la convergencia de las estadísticas de las finanzas públicas y la contabilidad pública en Europa a nivel central y local
2018
[EN] The main aim of this paper is to study the convergence between micro and macro systems of government accounting information, looking to contribute to the analysis of accounting harmonization process in the EU, as a tool to improve the comparability of financial, budgetary, and aggregated statistical reports, in order to improve social, political and economic decision-making and accountability. All this is obviously located in the current context of the EU, with a high degree of harmonization of accounting standards between the International Public Sector Accounting Standards (IPSAS), and those applied for the preparation of national accounts, ruled by European System of National and Re…