Search results for "CEDU"
showing 10 items of 2453 documents
Uterine rejection after allogeneic uterus transplantation in the rat is effectively suppressed by tacrolimus
2013
Objective To evaluate the effects of the immunosuppressant tacrolimus on rejection of a transplanted uterus and on uterine expression of markers of inflammation and implantation. Design Experimental study. Setting University laboratory. Animal(s) Female rats. Intervention(s) Uteri from brown Norway rats were transplanted to Lewis rats, receiving either tacrolimus or no treatment. Sham groups underwent either hemihysterectomy or tacrolimus treatment. Main Outcome Measure(s) Gross morphology, histology, density of T-lymphocytes by immunohistochemistry, and mRNA levels of interleukin (IL)-1α, leukemia inhibitory factor (LIF), galectin-1, CD200, IL-15, interferon-inducible protein-10 (IP-10), a…
Effect of CYP3A5*3 on kidney transplant recipients treated with tacrolimus: a systematic review and meta-analysis of observational studies
2014
The highly variable pharmacokinetics of tacrolimus can hamper the optimal management of kidney transplant patients. This variability has been attributed to the genetic polymorphism of CYP3A5 6986A>G, but the evidence is not clear. We conducted a meta-analysis of studies evaluating the effect of CYP3A5 polymorphism on kidney transplant recipients with tacrolimus plasma concentration divided by daily dose per body weight (C/D) and clinical outcomes. We searched in MEDLINE and EMBASE. We found evidence suggesting a significantly lower C/D among CYP3A5*1 allele carriers compared with carriers of the CYP3A5*3/*3 genotype at weeks 1 and 2, and months 1, 3, 6 and 12. We demonstrated that the expre…
Graphical THD minimization procedure for single phase five-level converters
2017
This paper proposes two graphycal procedure to mitigate h harmonics and to minimize the total harmonic distortion (THD), respectively. The paper considers a five-level inverter and fundamental frequency modulation: it computes the two switching angles able to reduce low order harmonics and able to minimize the THD. Simulation results are obtained and, in order to validate the proposed procedure, an experimental prototype is built and experimental results are carried out. The comparison between simulation and experimental results confirms the accuracy of the proposed graphycal procedure. It is shown that the switching angles to mitigate the third-fifth and the third-fifth-seventh harmonics e…
Arc crossing minimization in graphs with GRASP
2001
Graphs are commonly used to represent information in many fields of science and engineering. Automatic drawing tools generate comprehensible graphs from data, taking into account a variety of properties, enabling users to see important relationships in the data. The goal of limiting the number of arc crossings is a well-admitted criterion for a good drawing. In this paper, we present a Greedy Randomized Adaptive Search Procedure (GRASP) for the problem of minimizing arc crossings in graphs. Computational experiments with 200 graphs with up to 350 vertices are presented to assess the merit of the method. We show that simple heuristics are very fast but result in inferior solutions, while hig…
Transanal coloanal anastomosis for Hirschsprung's disease: comparison between endorectal and perirectal pull-through procedures.
2006
Le but de cette etude est de comparer les resultats de 2 techniques chirurgicales d'abaissement transanal par voie perineale pour maladie de Hirschsprung de forme recto-sigmoidienne. Materiel et Methode: Vingt-et-un patients porteurs de maladie de Hirschsprung de forme recto-sigmoidienne ont ete consecutivement operes entre novembre 1999 et avril 2003 dans les services de Chirurgie Pediatrique de Dijon et Strasbourg. Les 21 enfants ont ete operes par voie perineale transanale: Douze d'entre eux ont eu une dissection peri-rectale (TPR) et 9 une endorectale type Soave (TER). Les 2 groupes de patients ont ete compares pour la longueur du segment aganglionnaire, l'âge et le poids au moment de l…
The Thin bilateral and bipedicled DIEAP flap for axillary reconstruction in hidradenitis suppurativa
2019
Reconstruction after resection of advanced stage hidradenitis suppurativa is currently performed with pedicled perforator flaps, that allow functional reconstruction and preservation of shoulder function. Skin availability is limited by the possibility of closing the donor site primarily. Bilateral cases need to be treated in two stages, since the operation is carried out in the lateral decubitus. In this manuscript the application of bilateral and bipedicled DIEAP flaps to bilateral and extensive cases is presented.Between October 2008 and October 2018, 39 patients were treated for axillary hidradenitis suppurativa. Of these, 11 patients had bilateral reconstruction with bilateral DIEAP fl…
Improvements of General Multiple Test Procedures for Redundant Systems of Hypotheses
1988
In dieser Arbeit wird untersucht, welche Verscharfungen allgemeiner multipler Testprozeduren moglich sind, wenn die Kenntnis von „Redundanzen“ (logischen Abhangigkeiten) im Hypothesensystem ganz oder teilweise ausgenutzt wird. Fur den Fall gleicher Gewichtung der Elementartests werden mehrere verbesserte „statische“ Prozeduren angegeben, unter denen sich auch die „MSRB-Prozedur“ von Shaffer (1986) befindet. Last man auch ungleiche Gewichtung zu, so erhalt man vier verschiedene „dynamische“ Verbesserungen der Prozedur von Holm (1979), die in aufsteigender Reihenfolge immer trennscharfer, aber auch immer rechenaufwendiger werden. Es werden praktikable Algorithmen vorgestellt, die in einem ent…
A case report of a difficult dissection of the iliac vessels conducted by means of the harmonic scalpel during a kidney transplantation
2011
Background. The “difficult” preparation of iliac vessels in the kidney transplant recipient caused by a perivascular fibrosis with satellite lymphadenopathy is sometimes burdened by post-transplant complications (lymphocele, seroma and hematoma). Both iliac vascular adhesions and satellite lymphoadenopaty are often due to reiterate femoral cannulation aimed to hemodialysis. Patients and Methods: The case report concerns a 60 years old female uremic patient, on dialysis for about 4 years with perivascular fibrosis and pelvic lymphadenopathy caused by bilateral femoral artery catheterization. In the course of kidney transplant, preparation of the iliac vessels was performed by ultrasonic scal…
Adjustable tourniquet to manipulate pulmonary blood flow after Norwood operations
2000
Abstract Background . Survival after first-stage palliative Norwood operations for single ventricle with systemic outflow obstruction is mainly dependent on a balanced ratio of pulmonary blood flow to systemic blood flow. Here we report the clinical results using a modified technique that allows a controlled systemic-to-pulmonary shunt flow to prevent pulmonary overcirculation. Methods . From 1995 to 1998, of 26 infants undergoing first-stage palliative Norwood operations, 7 had placement of an adjustable tourniquet around a modified right Blalock-Taussig shunt. Results . Hospital survival was 20 of 26 patients (77%). All 7 patients in whom snaring of the shunt was indicated survived. Two p…
What Is the Role of Minimally Invasive Mitral Valve Surgery in High-Risk Patients? A Meta-Analysis of Observational Studies
2016
Background. Minimally invasive valve surgery is related to certain better postoperative outcomes. We aimed to assess the role of minimally invasive mitral valve surgery in high-risk patients. Methods. A systematic literature review identified eight studies of which seven fulfilled criteria for metaanalysis. Outcomes for a total of 1,254 patients (731 were conventional standard sternotomy and 523 were minimally invasive mitral valve surgery) were submitted to meta-analysis using random effects modeling. Heterogeneity and subgroup analysis with quality scoring were assessed. The primary end point was early mortality. Secondary end points were intraoperative and postoperative outcomes and long…