Search results for "CLEAR"
showing 10 items of 27042 documents
68 ga-dotatoc pet/ct follow up after single or hypofractionated gamma knife icon radiosurgery for meningioma patients
2021
68Ga-DOTATOC represents a useful tool in tumor contouring for radiosurgery planning. We present a case series of patients affected by meningiomas on who we performed 68Ga-DOTATOC positron emission tomography (PET)/CT pre-operatively, a subgroup of which also underwent a post-operative 68Ga-DOTATOC PET/CT to evaluate the standardized uptake value (SUV) modification after Gamma Knife ICON treatment in single or hypofractionated fractions. Twenty patients were enrolled/included in this study: ten females and ten males. The median age was 52 years (range 33–80). The median tumor diameter was 3.68 cm (range 0.12–22.26 cm), and the median pre-radiotherapy maximum SUV value was 11 (range 2.3–92). …
Intrahematomal Ultrasound Enhances RtPA-Fibrinolysis in a Porcine Model of Intracerebral Hemorrhage
2021
Catheter-based ultrasound-thrombolysis has been successfully used in a small clinical trial in order to enhance recombinant tissue plasminogen activator (rtPA)-fibrinolysis, for the treatment of spontaneous intracerebral hemorrhages (ICHs). The aim of this study was to investigate the ultra-early effects of ultrasound on hematoma and the surrounding brain tissue in a porcine ICH-model. To achieve this, 21 pigs with a right frontal ICH were randomly assigned to four groups: (1) drainage (n = 3), (2) drainage + rtPA (n = 6), (3) drainage + ultrasound (n = 6), and (4) drainage + ultrasound + rtPA (n = 6). The hematoma volume assessment was performed using cranial MRI before and after the treat…
What we learn about bipolar disorder from large-scale neuroimaging
2020
Abstract MRI‐derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta‐Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis‐driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Workin…
K∗(892)0 and ϕ(1020) production in Pb-Pb collisions at √sNN =2.76 TeV
2015
The yields of the K∗(892)0 and ϕ(1020) resonances are measured in Pb-Pb collisions at √sNN=2.76 TeV through their hadronic decays using the ALICE detector. The measurements are performed in multiple centrality intervals at mid-rapidity (|y|<0.5) in the transverse-momentum ranges 0.3<pT<5 GeV/c for the K∗(892)0 and 0.5<pT<5 GeV/c for the ϕ(1020). The yields of K∗(892)0 are suppressed in central Pb-Pb collisions with respect to pp and peripheral Pb-Pb collisions (perhaps due to rescattering of its decay products in the hadronic medium), while the longer-lived ϕ(1020) meson is not suppressed. These particles are also used as probes to study the mechanisms of particle production. The shape of t…
Dynamical Hadrons: Case Studies of Meson-Meson and Meson-Baryon Molecules and Triangle Singularities
2020
In this thesis we use various methods to study the interaction of hadrons. We focus on topics related to exotic hadrons, such as tetraquarks from meson-meson interaction, pentaquarks from meson-baryon, and also triangular singularities. We show how experimental data can be explained with our theoretical models, and make predictions that can be compared with future experiments. In chapter 1 we show our method to describe meson-meson interactions, known as chiral unitary approach, showing how the interaction of pseudoscalars generates the f0(500), f0(980) and a0(980), which appear in the two articles discussed in this chapter: that of the eta_c -> eta pi+ pi- decay, and that of the a0(980)-f0…
Observation of the rare decay K-S -> pi(0)e(+)e(-)
2003
A search for the decay Ks->pi0e+e- has been made by the NA48/1 experiment at the CERN SPS accelerator. Using data collected during 89 days in 2002 with a high-intensity Ks beam, 7 events were found with a background of 0.15 events. The branching fraction BR(Ks->pi0e+e-, m(ee) > 0.165 GeV/c^2) = (3.0^{+1.5}_{-1.2}(stat) +/-0.2 (syst)) x 10^{-9} has been measured. Using a vector matrix element and a form factor equal to one, the measurement gives BR(Ks->pi0e+e-) = (5.8^{+2.9}_{-2.4}) x 10^{-9}.
Observation of the decay KS→π+π−e+e−
2000
Abstract We present the first observation of the decay KS→π+π−e+e− based upon the data collected in 1998 by the NA48 experiment at CERN. We have identified a clean sample of 56 events with negligible background contamination. Using KL→π+π−π0D decays as normalization sample, the branching ratio is measured to be BR(KS→π+π−e+e−)=[4.5±0.7(stat)±0.4(syst)]×10−5. This result is in good agreement with the theoretical expectations from the mechanism of inner bremsstrahlung.
Branched-Chain Amino Acid Deprivation Decreases Lipid Oxidation and Lipogenesis in C2C12 Myotubes
2022
Impaired lipid metabolism is a common risk factor underlying several metabolic diseases such as metabolic syndrome and type 2 diabetes. Branched-chain amino acids (BCAAs) that include valine, leucine and isoleucine have been proven to share a role in lipid metabolism and hence in maintaining metabolic health. We have previously introduced a hypothesis suggesting that BCAA degradation mechanistically connects to lipid oxidation and storage in skeletal muscle. To test our hypothesis, the present study examined the effects of BCAA deprivation and supplementation on lipid oxidation, lipogenesis and lipid droplet characteristics in murine C2C12 myotubes. In addition, the role of myotube contract…
Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex.
2012
Expansion of CAG repeats is a common feature of various neurodegenerative disorders, including Huntington's disease. Here we show that expanded CAG repeats bind to a translation regulatory protein complex containing MID1, protein phosphatase 2A and 40S ribosomal S6 kinase. Binding of the MID1-protein phosphatase 2A protein complex increases with CAG repeat size and stimulates translation of the CAG repeat expansion containing messenger RNA in a MID1-, protein phosphatase 2A- and mammalian target of rapamycin-dependent manner. Our data indicate that pathological CAG repeat expansions upregulate protein translation leading to an overproduction of aberrant protein and suggest that the MID1-com…
The E3 Ubiquitin Ligase MID1 Catalyzes Ubiquitination and Cleavage of Fu
2014
Sonic Hedgehog (SHH)-GLI signalling plays an important role during embryogenesis and in tumorigenesis. The survival and growth of several types of cancer depend on autonomously activated SHH-GLI signalling. A protein complex containing the ubiquitin-ligase MID1 and protein phosphatase 2A (PP2A) regulates the nuclear localization and transcriptional activity of GLI3, a transcriptional effector molecule of SHH, in cancer cell lines with autonomously activated SHH signalling. However, the exact molecular mechanisms that mediate the interaction between MID1 and GLI3 remained unknown. Here, we show that MID1 catalyses the ubiquitination and proteasomal cleavage of the GLI3-regulator Fu. Our data…