Search results for "COMB"
showing 10 items of 7115 documents
Synthesis of new polydentate oxalamide-based ligands as chiral catalysts for the enantioselective addition of diethylzinc to benzaldehyde
2006
New polydentate oxalamide-based ligands have been studied as chiral catalysts in the enantioselective addition of diethylzinc to benzaldehyde
ChemInform Abstract: Stereoselective Nucleophilic Addition Reactions of Reactive Pseudopeptides.
2010
ChemInform Abstract: Enantioselective Zinc-Mediated Conjugate Addition of Terminal Alkynes to Enones.
2013
Zinc for conjugate alkynylation: The enantioselective conjugate addition of terminal alkynes to 2-arylidene-1,3-diketones in the presence of diethylzinc and a catalytic amount of (R)-VANOL has been developed. The reaction can be applied to different aromatic and heteroaromatic alkynes and enones, giving the expected products in good yield and with enantiomeric excesses up to 91%. The products can be enantiomerically enriched up to 99% ee by crystallization (see scheme).
Viral exanthema as manifestation of SARS-CoV-2 infection
2020
Abstract Rationale: The clinical manifestations of the SARS-CoV-2 infection are mainly respiratory but the virus can cause a variety of symptoms. Dermatological findings are less well-characterized. Data is scarce on their timing, type and correlation with the immune response. Patient concerns: We present the case of SARS-CoV-2 infection in a previously healthy woman who presented with respiratory symptoms and developed anosmia, diarrhea, and an erythematous maculo-papular rash on day 15 from symptom onset. Diagnosis: The nasopharyngeal swab tested by real time PCR for COVID-19 was positive. We interpreted this as a viral exanthema likely caused by an immune response to SARS-CoV-2 nucleotid…
Comparison of combined application treatment with one-visit varnish treatments in an orthodontic population
2013
Objective: To evaluate the effect of chlorhexidine-thymol varnish alone, its combination with chlorhexidine-fluo - ride containing dentifrice and fluoride varnish on oral hygiene and caries prevention in orthodontic patients. Study design: Sixty patients, aged 12-18, with orthodontic fixed appliances were randomly assigned into three groups as follows: Group 1 (n=20): 1% chlorhexidine and 1% thymol varnish (Cervitec ® Plus); Group 2 (n=20): Cervitec ® Plus+ 0.2% chlorhexidine and 0.2% sodium fluoride (900 ppm fluoride) (Cervitec ® Gel)); and Group 3 (n=20): 0.1% fluoride varnish (Fluor Protector ® ). Mutans streptococci (MS), lactobacilli (LB) levels, buffering capacity (BC), visible plaque…
Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells
2009
AbstractTo study B-cell development from bone marrow (BM), we generated recombination-activating gene 1 (Rag1)–targeted mice lacking mature lymphocytes. B-cell development can be induced in such mice by B cell–specific restoration of a functional Rag1 transcription unit. Follicular and marginal zone B cells populated the spleen when Rag1 expression was permitted. Notably, the peritoneal cavity was dominated by bona fide B-1a cells, as judged by surface markers and functional properties. These BM-derived B-1a cells exhibited a polyclonal VDJ repertoire with substantial N nucleotide insertions. Nevertheless, physiologic frequencies of phosphatidylcholine-specific B cells were detected. Import…
T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice.
2013
Background & Aims Antiviral agents suppress hepatitis B virus (HBV) replication but do not clear the infection. A strong effector T-cell response is required to eradicate HBV, but this does not occur in patients with chronic infection. T cells might be directed toward virus-infected cells by expressing HBV-specific receptors and thereby clear HBV and help to prevent development of liver cancer. In mice, we studied whether redirected T cells can engraft after adoptive transfer, without prior T-cell depletion, and whether the large amounts of circulating viral antigens inactivate the transferred T cells or lead to uncontrolled immune-mediated damage. Methods CD8 + T cells were isolated from m…
Augmented Passive Transfer of Contact Sensitivity in Severe Combined Immunodeficiency Mice and Its Dependence of Vβ8<sup>+</sup> Cells in…
1993
The passive transfer of contact sensitivity using picryl chloride immune cells from H-2 syngenic BALB/c donors was analyzed in severe combined immunodeficiency (SCID) mice which lack functional T and B lymphocytes. H-2-restricted and antigen-specific contact sensitivity was transferred to SCID mice, and comparison between the level of contact sensitivity and the number of transferred cells showed a significantly more efficient transfer to SCID than to BALB/c mice. The cells passively transferring contact sensitivity were shown to carry the Vβ8 phenotype. Moreover, chromium-labeled cells from BALB/c PC1-primed donors localize normally in peripheral lymphoid organs, and an increased percentag…
Early management of COPD: Where are we now and where do we go from here? a delphi consensus project
2019
Fabiano Di Marco,1 Piero Balbo,2 Francesco de Blasio,3 Vittorio Cardaci,4 Nunzio Crimi,5 Giuseppe Girbino,6 Girolamo Pelaia,7 Pietro Pirina,8 Pietro Roversi,9 Pierachille Santus,10,11 Nicola Scichilone,12 Alessandro Vatrella,13 Patrizio Pasqualetti,14 Mauro Carone15 1Department of Health Sciences, University of Milan, Respiratory Unit, Papa Giovanni XXIII Hospital, Bergamo, Italy; 2SC Malattie dell&rsquo;Apparato Respiratorio, AOU Maggiore della Carit&agrave;, Novara, Italy; 3Respiratory Medicine and Pulmonary Rehabilitation Section, Clinic Center S.p.A. Private Hospital, Department of Medicine and Health Sciences &ldquo;V Tiberio&rdquo;, University of Molise, Campobasso, It…
Mono- and Multi-Layers
2006
Thin films incorporating or consisting of calixarenes have been widely investigated. The capacity of such films to adsorb both ions and neutral species has engendered particular interest in their use in sensor devices. Semiconductors, non-linear optical and pyroelectric materials or switchable systems for data storage are further examples of their potential use [1]. Both monoand multi-layer films can be formed from calixarenes and resorcarenes, using a variety of techniques. This chapter deals with the fundamental basis of calixarene thin film applications, including film formation and characterisation as well as studies of selectivity in small molecule interactions. Real and potential appl…