Search results for "Centre"

showing 10 items of 478 documents

Macroalgal responses to ocean acidification depend on nutrient and light levels

2015

Ocean acidification may benefit algae that are able to capitalize on increased carbon availability for photosynthesis, but it is expected to have adverse effects on calcified algae through dissolution. Shifts in dominance between primary producers will have knock-on effects on marine ecosystems and will likely vary regionally, depending on factors such as irradiance (light vs. shade) and nutrient levels (oligotrophic vs. eutrophic). Thus experiments are needed to evaluate interactive effects of combined stressors in the field. In this study, we investigated the physiological responses of macroalgae near a CO2 seep in oligotrophic waters off Vulcano (Italy). The algae were incubated in situ …

Ocean Acidification International Coordination Centre (OA-ICC)TemperateSalinityChlorophyll aFucoxanthininorganicAlkalinityPhotosynthetic efficiency standard errorChlorophyll cNitrogen content per dry mass standard errorLight saturation point standard errorPhenolics allTemperature waterCarbon inorganic dissolvedMacroalgaeCalculated using seacarb after Nisumaa et al 2010Carbon Nitrogen ratioAragonite saturation stateAlkalinity totalallCarbon per dry massSalinity standard errortotalCarbon content per dry mass standard errorPhenolics all standard errorCO2 ventChromistapHMaximum photochemical quantum yield of photosystem II standard errorTemperaturePartial pressure of carbon dioxide (water) at sea surface temperature (wet air) standard errordissolvedAntioxidant activity standard errorCarbonate ionMaximum photochemical quantum yield of photosystem IIPartial pressure of carbon dioxide (water) at sea surface temperature (wet air)Field experimentstandard errorNitrogen content per dry massElectron transport rate standard errorFucoxanthin standard errorEarth System ResearchViolaxanthinPhenolicsChlorophyll a standard errorCarbon dioxide standard errorPotentiometric titrationCalcite saturation stateCarbon/Nitrogen ratio standard errorNitrogenOchrophytaPotentiometricper dry masswaterChlorophyll c standard errorBenthosAlkalinity total standard errorAntioxidant activityElectron transport rateLight saturation pointOcean Acidification International Coordination Centre OA ICCMacro-nutrientsMediterranean SeaNitrogen per dry massBicarbonate ionTemperature water standard errorCalculated using seacarb after Nisumaa et al. (2010)Primary production PhotosynthesisSpeciespH standard errorCalcite saturation state standard errorCystoseira compressaCalculated using CO2SYSNon photochemical quenchingCarbon content per dry massCarbonate system computation flagViolaxanthin standard errorPrimary production/PhotosynthesisFugacity of carbon dioxide (water) at sea surface temperature (wet air)CarbonCarbon/Nitrogen ratioBiomass/Abundance/Elemental compositionTreatmentPartial pressure of carbon dioxide water at sea surface temperature wet airAragonite saturation state standard errorCarbon dioxideMacro nutrientsCarbonate ion standard errorSingle speciesFugacity of carbon dioxide water at sea surface temperature wet airPadina pavonicaBiomass Abundance Elemental compositionCoast and continental shelfPhotosynthetic efficiencyBicarbonate ion standard errorNon photochemical quenching standard error
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Seagrass ecosystem response to long-term high CO2 in a Mediterranean volcanic vent

2014

We examined the long-term effect of naturally acidified water on a Cymodocea nodosa meadow growing at a shallow volcanic CO2 vent in Vulcano Island (Italy). Seagrass and adjacent unvegetated habitats growing at a low pH station (pH = 7.65 ± 0.02) were compared with corresponding habitats at a control station (pH = 8.01 ± 0.01). Density and biomass showed a clear decreasing trend at the low pH station and the below- to above-ground biomass ratio was more than 10 times lower compared to the control. C content and delta 13C of leaves and epiphytes were significantly lower at the low pH station. Photosynthetic activity of C. nodosa was stimulated by low pH as seen by the significant increase in…

Ocean Acidification International Coordination Centre (OA-ICC)TemperateSalinityChlorophyll ainorganicAlkalinityLight saturation point standard errorPhotosynthetic quantum efficiencyMediterranean Sea Acidification in a Changing Climate MedSeATemperature waterCarbon inorganic dissolvedCalculated using seacarb after Nisumaa et al 2010IrradianceRespiration rate carbonAragonite saturation stateBiomassAlkalinity totalIrradiance standard errortotalCO2 ventCymodocea nodosapHRespirationEpiphytes loadMaximum photochemical quantum yield of photosystem II standard errorNet community production of carbonTemperaturePartial pressure of carbon dioxide (water) at sea surface temperature (wet air) standard errordissolvedRespiration rate carbon standard errorCarbonate ionMaximum photochemical quantum yield of photosystem IIPartial pressure of carbon dioxide (water) at sea surface temperature (wet air)Net community production of carbon standard errorIlluminance standard errorSoft bottom communitystandard errorCarbon inorganic dissolved standard errorRespiration rateElectron transport rate standard errorEarth System Researchδ13CPhotosynthetic quantum efficiency standard errorField observationChlorophyll a standard errorGross primary production of carbonBiomass standard errorCalcium carbonatePotentiometric titrationCalcite saturation stateShoot densityPotentiometricwaterIlluminanceOxygen standard errorBenthosAlkalinity total standard errorMediterranean Sea Acidification in a Changing Climate (MedSeA)Electron transport rateLight saturation pointOcean Acidification International Coordination Centre OA ICCMediterranean SeaGross primary production of carbon standard errorBicarbonate ionSoft-bottom communityδ13C standard errorTemperature water standard errorCalculated using seacarb after Nisumaa et al. (2010)Primary production PhotosynthesisSpeciespH standard errorCarbonate system computation flagloadPrimary production/PhotosynthesisFugacity of carbon dioxide (water) at sea surface temperature (wet air)CarbonBiomass/Abundance/Elemental compositionTreatmentEpiphytes load standard errorOxygenPartial pressure of carbon dioxide water at sea surface temperature wet airEpiphytes loadCarbon dioxideCarbon standard errorEntire communityFugacity of carbon dioxide water at sea surface temperature wet airGroupBiomass Abundance Elemental compositionCoast and continental shelfEpiphytesShoot density standard errorCalcium carbonate standard error
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Seawater carbonate chemistry and coralline algal diversity

2021

Calcified coralline algae are ecologically important in rocky habitats in the marine photic zone worldwide and there is growing concern that ocean acidification will severely impact them. Laboratory studies of these algae in simulated ocean acidification conditions have revealed wide variability in growth, photosynthesis and calcification responses, making it difficult to assess their future biodiversity, abundance and contribution to ecosystem function. Here, we apply molecular systematic tools to assess the impact of natural gradients in seawater carbonate chemistry on the biodiversity of coralline algae in the Mediterranean and the NW Pacific, link this to their evolutionary history and …

Ocean Acidification International Coordination Centre (OA-ICC)TemperateSalinityCommunity composition and diversityBicarbonate ion standard deviationinorganicAlkalinity total standard deviationAlkalinityExperimentTemperature waterCarbon inorganic dissolvedCalculated using seacarb after Nisumaa et al 2010Aragonite saturation stateNorth PacificMarine habitatAlkalinity totaltotalCO2 ventpHTemperaturedissolvedCarbonate ionPartial pressure of carbon dioxide (water) at sea surface temperature (wet air)Calcium carbonate standard deviationstandard errorEarth System Researchstandard deviationField observationCalcium carbonateCoverageCalcite saturation stateLocationwaterPartial pressure of carbon dioxideSiteRocky-shore communityCalcium carbonate massAragonite saturation state standard deviationBenthosSalinity standard deviationOcean Acidification International Coordination Centre OA ICCMediterranean SeaCarbon inorganic dissolved standard deviationCalcite saturation state standard deviationTypeBicarbonate ionCalculated using seacarb after Nisumaa et al. (2010)Coverage standard errorfungiEvent labelPartial pressure of carbon dioxide standard deviationCarbonate system computation flagpH standard deviationCarbonate ion standard deviationFugacity of carbon dioxide (water) at sea surface temperature (wet air)CarbonPartial pressure of carbon dioxide water at sea surface temperature wet airCarbon dioxideRocky shore communityEntire communityFugacity of carbon dioxide water at sea surface temperature wet airCoast and continental shelfSpecies richness
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Decline in Coccolithophore Diversity and Impact on Coccolith Morphogenesis Along a Natural CO2 Gradient

2014

A natural pH gradient caused by marine CO2 seeps off Vulcano Island (Italy) was used to assess the effects of ocean acidification on coccolithophores, which are abundant planktonic unicellular calcifiers. Such seeps are used as natural laboratories to study the effects of ocean acidification on marine ecosystems, since they cause long-term changes in seawater carbonate chemistry and pH, exposing the organisms to elevated CO2 concentrations and therefore mimicking future scenarios. Previous work at CO2 seeps has focused exclusively on benthic organisms. Here we show progressive depletion of 27 coccolithophore species, in terms of cell concentrations and diversity, along a calcite saturation …

Ocean Acidification International Coordination Centre (OA-ICC)TemperateSalinityCommunity composition and diversityinorganicAlkalinityCoccospheres malformedMediterranean Sea Acidification in a Changing Climate MedSeATemperature waterCarbon inorganic dissolvedCalculated using seacarb after Nisumaa et al 2010Aragonite saturation stateAlkalinity totaltotalCO2 ventpHPelagosTemperaturedissolvedCarbonate ionPartial pressure of carbon dioxide (water) at sea surface temperature (wet air)Earth System ResearchmalformedField observationPotentiometric titrationCalcite saturation stateCoccospheresPotentiometricwaterGrowth MorphologyMediterranean Sea Acidification in a Changing Climate (MedSeA)Ocean Acidification International Coordination Centre OA ICCMediterranean SeaBicarbonate ionCalculated using seacarb after Nisumaa et al. (2010)Calculated using CO2SYSfungiCarbonate system computation flagCoccospheres corrodedFugacity of carbon dioxide (water) at sea surface temperature (wet air)CarbonBiomass/Abundance/Elemental compositionPartial pressure of carbon dioxide water at sea surface temperature wet airSample IDCarbon dioxidecorrodedEntire communityGrowth/MorphologyPhytoplanktonFugacity of carbon dioxide water at sea surface temperature wet airBiomass Abundance Elemental compositionCoast and continental shelfNumber of species
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Shallow water marine sediment bacterial community shifts along a natural CO2 gradient in the Mediterranean Sea Off vulcano, Italy

2014

The effects of increasing atmospheric CO(2) on ocean ecosystems are a major environmental concern, as rapid shoaling of the carbonate saturation horizon is exposing vast areas of marine sediments to corrosive waters worldwide. Natural CO(2) gradients off Vulcano, Italy, have revealed profound ecosystem changes along rocky shore habitats as carbonate saturation levels decrease, but no investigations have yet been made of the sedimentary habitat. Here, we sampled the upper 2 cm of volcanic sand in three zones, ambient (median pCO(2) 419 µatm, minimum Omega (arag) 3.77), moderately CO(2)-enriched (median pCO(2) 592 µatm, minimum Omega (arag) 2.96), and highly CO(2)-enriched (median pCO(2) 1611…

Ocean Acidification International Coordination Centre (OA-ICC)TemperateSalinityPotentiometric titrationCalcite saturation stateCommunity composition and diversityPotentiometricinorganicwaterAlkalinitySiteFigureBenthosTemperature waterCarbon inorganic dissolvedAbundanceCalculated using seacarb after Nisumaa et al 2010Ocean Acidification International Coordination Centre OA ICCMediterranean SeaBicarbonate ionAragonite saturation stateSoft-bottom communityAlkalinity totalLONGITUDEtotalCalculated using seacarb after Nisumaa et al. (2010)CO2 ventSpeciesShannon Diversity IndexpHCalculated using CO2SYSTemperatureCarbonate system computation flagdissolvedFugacity of carbon dioxide (water) at sea surface temperature (wet air)Carbonate ionCarbonPartial pressure of carbon dioxide (water) at sea surface temperature (wet air)Partial pressure of carbon dioxide water at sea surface temperature wet airCarbon dioxideSoft bottom communityEntire communityEarth System ResearchLATITUDEFugacity of carbon dioxide water at sea surface temperature wet airGroupCoast and continental shelfField observationClass
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Whole-brain radiotherapy or autologous stem-cell transplantation as consolidation strategies after high-dose methotrexate-based chemoimmunotherapy in…

2017

Background The International Extranodal Lymphoma Study Group-32 (IELSG32) trial is an international randomised phase 2 study that addresses two key clinical questions in the treatment of patients with newly diagnosed primary CNS lymphoma. Results of the first randomisation have demonstrated that methotrexate, cytarabine, thiotepa, and rituximab (called the MATRix regimen) is the induction combination associated with significantly better outcome compared with the other induction combinations tested. Here, we report the results of the second randomisation that addresses the efficacy of myeloablative chemotherapy supported by autologous stem-cell transplantation (ASCT), as an alternative to wh…

OncologyAdultMalemedicine.medical_specialtyautologous stem cell transplantationAdolescentLymphomaMedizinprimary CNS lymphoma whole brain radiotherapy autologous stem cell transplantationPhases of clinical researchThioTEPATransplantation AutologousDisease-Free SurvivalCentral Nervous System Neoplasms03 medical and health sciencesYoung Adult0302 clinical medicineAutologous stem-cell transplantationprimary CNS lymphomaChemoimmunotherapyInternal medicineJournal ArticleMedicineHumansAgedManchester Cancer Research CentreDose-Response Relationship Drugbusiness.industryResearchInstitutes_Networks_Beacons/mcrcInduction chemotherapyBrainHematologyMiddle AgedCombined Modality Therapy3. Good healthSurgeryTransplantationRegimenMethotrexate030220 oncology & carcinogenesiswhole brain radiotherapyRituximabFemalebusiness030215 immunologymedicine.drugStem Cell Transplantation
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Eribulin mesylate use as third-line therapy in patients with metastatic breast cancer (VESPRY): a prospective, multicentre, observational study

2019

Background: In real-world practice, eribulin mesylate provides significant survival benefit, with a manageable safety profile in heavily pretreated patients with metastatic breast cancer (MBC). Methods: In this prospective, open-label, multicentre, observational study we evaluated the effectiveness and tolerability of eribulin as third-line treatment in a homogeneous population. The primary endpoints were the safety profile and response in metastatic sites; secondary endpoints included the response in different subtypes, overall response rate (ORR), progression-free survival (PFS) and overall survival (OS). Results: From 2013 to 2016, 118 women were treated in 21 Sicilian institutions; the …

OncologyEribulin Mesylatemedicine.medical_specialtymulticentreThird-line therapylcsh:RC254-282chemistry.chemical_compoundInternal medicinemedicineIn patienteribulin metastatic breast cancer multicentre prospective real world third lineeribulinthird lineOriginal Researchbusiness.industryreal worldprospectivemedicine.diseaselcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensMetastatic breast cancerSafety profileSurvival benefitOncologychemistryObservational studymetastatic breast cancerbusinessEribulinTherapeutic Advances in Medical Oncology
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Testicular germ-cell tumours and penile squamous cell carcinoma: Appropriate management makes the difference

2019

Germ-cell tumours (GCT) of the testis and penile squamous cell carcinoma (PeSCC) are a rare and a very rare uro-genital cancers, respectively. Both tumours are well defined entities in terms of management, where specific recommendations - in the form of continuously up-to-dated guide lines- are provided. Impact of these tumour is relevant. Testicular GCT affects young, healthy men at the beginning of their adult life. PeSCC affects older men, but a proportion of these patients are young and the personal consequences of the disease may be devastating. Deviation from recommended management may be a reason of a significant prognostic worsening, as proper treatment favourably impacts on these t…

OncologyMaleSurvival030232 urology & nephrologyDiseaseCarcinoma; Community network; Europe; Germ cell and embryonal; Neoplasms; Penis neoplasms; Rare diseases; Squamous cell; Survival; Tertiary care centres; Testicular neoplasms; Surgery; Oncology0302 clinical medicineNeoplasmsEpidemiologyTesticular neoplasmReferral and ConsultationPenis neoplasmsCarcinoma ; Community network ; Europe ; Germ cell and embryonal ; Neoplasms ; Penis neoplasms ; Rare diseases ; Squamous cell ; Survival ; Tertiary care centres ; Testicular neoplasmsGeneral MedicineNeoplasms Germ Cell and EmbryonalTertiary care centreRare diseasesSurvival RateEuropeOncology030220 oncology & carcinogenesisLymphatic MetastasisCarcinoma Squamous CellHumanmedicine.medical_specialtyTesticular neoplasmsPenile squamous cell carcinomaGerm cell and embryonalCommunity networkSocio-culturaleCancer Care FacilitiesTertiary care centres03 medical and health sciencesPenis neoplasmRare DiseaseInternal medicinemedicineCarcinomaHumansPenile NeoplasmsNeoplasm StagingPenis Neoplasmsbusiness.industryCancer Care FacilitieSquamous cellCarcinomaLymphatic Metastasimedicine.diseaseTesticular germ cellAdult lifePenile NeoplasmProper treatmentNeoplasmLymph Node ExcisionSurgerybusinessDelivery of Health Care
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Centre characteristics and procedure-related factors have an impact on outcomes of allogeneic transplantation for patients with CLL: a retrospective …

2017

Abstract Introduction:Even in the era of novel targeted therapies for the treatment of Chronic Lymphocytic Leukemia (CLL) patients, such as BTK, PI3K and BCL2 inhibitors, allogeneic hematopoietic stem cell transplantations (alloHCT) will remain an important treatment option for a subset of patients with very high risk CLL. The current study focused on the impact of center and procedure-related factors on outcomes after alloHCT, taking into account the impact of patient- and disease-related risk factors. Patients and Methods:Data of 684 CLL patients who received a first alloHCT between 2000 and 2011 were analyzed. Their data were collected as part of the EBMT CLL Data Quality Initiative. Out…

OncologyMaleTransplantation ConditioningCancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2]Chronic lymphocytic leukemiaMedizinQUALITY MANAGEMENT-SYSTEMKaplan-Meier Estimaterisk factor analysisGUIDELINESBiochemistryallogeneic stem cell transplantation; centre effects; chronic lymphocytic leukaemia; frailties; risk factor analysiscentre effectsTransplantation Conditioning / methods0302 clinical medicineRecurrenceRisk Factorsallogeneic stem cell transplantationLeukemia Lymphocytic Chronic B-Cell / mortalityRegistriesDelivery of Health Care / statistics & numerical dataIBRUTINIBddc:6160303 health sciencesALEMTUZUMABHazard ratioHematopoietic Stem Cell TransplantationProfessional PracticeHematologyMiddle Aged3. Good healthEurope030220 oncology & carcinogenesisABT-199CohortSURVIVALAlemtuzumabFemaleEurope / epidemiologymedicine.drugAdultmedicine.medical_specialtyAllogeneic transplantationImmunologyLower riskDIAGNOSISSettore MED/01 - Statistica Medica03 medical and health sciencesLeukemia Lymphocytic Chronic B-Cell / therapyHematopoietic Stem Cell Transplantation / methodsInternal medicinemedicineHumansKarnofsky Performance Status030304 developmental biologyAgedRetrospective Studiesbusiness.industryProportional hazards modelCHRONIC LYMPHOCYTIC-LEUKEMIARetrospective cohort studySTEM-CELL TRANSPLANTATIONCell Biologymedicine.diseaseLeukemia Lymphocytic Chronic B-CellConfidence intervalSurgeryProfessional Practice / statistics & numerical dataTransplantationbusinessDelivery of Health Carefrailtieschronic lymphocytic leukaemia030215 immunologyRESPONSES
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Prognostic factors for progression-free and overall survival in advanced biliary tract cancer

2015

BACKGROUND: Biliary tract cancer is an uncommon cancer with a poor outcome. We assembled data from the National Cancer Research Institute (UK) ABC-02 study and 10 international studies to determine prognostic outcome characteristics for patients with advanced disease.METHODS: Multivariable analyses of the final dataset from the ABC-02 study were carried out. All variables were simultaneously included in a Cox proportional hazards model, and backward elimination was used to produce the final model (using a significance level of 10%), in which the selected variables were associated independently with outcome. This score was validated externally by receiver operating curve (ROC) analysis using…

Oncologymedicine.medical_specialtyDisease-Free SurvivalCholangiocarcinoma03 medical and health sciencesAdvanced diseaseCisplatin and gemcitabine0302 clinical medicineInternal medicinemedicineJournal ArticleHumansProgression-free survivalProportional Hazards ModelsPerformance statusReceiver operating characteristicManchester Cancer Research Centrebusiness.industryProportional hazards modelResearch Support Non-U.S. Gov'tResearchInstitutes_Networks_Beacons/mcrcHazard ratioArea under the curveCancerHematologymedicine.diseasePrognosisConfidence intervalSurgeryTreatment OutcomeOncologyBile Duct NeoplasmsROC Curve030220 oncology & carcinogenesisABC-02Multivariate AnalysisBiliary tract cancer030211 gastroenterology & hepatologybusinessPerformance statusPrognostic modelMeta-Analysis
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