Search results for "Cognitive Dysfunction"

showing 10 items of 175 documents

A Longitudinal Study of Episodic and Semantic Autobiographical Memory in aMCI and Alzheimer’s Disease Patients

2021

Background: The main objective of this study was to analyze the evolution of autobiographical memory (both episodic and semantic) in patients with mild cognitive impairment, patients with Alzheimer’s disease, and a healthy control group. We compared these groups at two time points: first, at baseline, and in a follow-up after 18 months. Method: Twenty-six healthy older adults, 17 patients with mild amnestic cognitive impairment, and 16 patients with Alzheimer’s disease, matched on age and educational level, were evaluated at both time points with the Autobiographical Memory Interview. Results: The results showed significant longitudinal deterioration in episodic and semantic autobiographica…

Longitudinal studymedicine.medical_specialtyHealth Toxicology and MutagenesisMemory EpisodicDiseaseAudiologyNeuropsychological Tests050105 experimental psychologyArticle03 medical and health sciencesAutobiographical memory interview0302 clinical medicinemild cognitive impairmentAlzheimer DiseaseHealthy controlmedicineHumans0501 psychology and cognitive sciencesIn patientCognitive DysfunctionLongitudinal StudiesCognitive impairmentAgedAutobiographical memorybusiness.industry05 social sciencesautobiographical memoryPublic Health Environmental and Occupational HealthRSemanticsMedicinebusinessAlzheimer’s disease030217 neurology & neurosurgeryInternational Journal of Environmental Research and Public Health
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Oral Health Status in Subjects with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: Data from the Zabút Aging Project

2020

Background: The relationship between Alzheimer’s disease (AD) and periodontitis has been recently investigated with heterogenous results. Objective: This study aims to evaluate the oral health status and its relationship with cognitive impairment of participants, enrolled in the Zabút Aging Project, a community-based cohort study performed in a rural community in Sicily, Italy. Methods: A case-control study (20 subjects with AD, 20 with amnestic mild cognitive impairment [aMCI], and 20 controls) was conducted. The protocol included a comprehensive medical and cognitive-behavioral examination. Full-mouth evaluation, microbial analysis of subgingival plaque samples (by RT-PCR analysis), and o…

Male0301 basic medicineAgingmedicine.medical_specialtyPopulationOral HealthNeuropsychological TestsCohort Studies03 medical and health sciences0302 clinical medicinestomatognathic systemQuality of lifeAlzheimer DiseaseInternal medicineEpidemiologyTooth lossmedicineHumansCognitive DysfunctioneducationPeriodontitiseducation.field_of_studybiologybusiness.industryGeneral NeuroscienceAlzheimer’s disease cognitive impairment epidemiology oral health periodontitis tooth lossGeneral Medicinemedicine.diseasebiology.organism_classificationChronic periodontitisstomatognathic diseasesPsychiatry and Mental healthClinical Psychology030104 developmental biologyCase-Control StudiesQuality of LifeGeriatrics and Gerontologymedicine.symptomFusobacterium nucleatumbusiness030217 neurology & neurosurgeryCohort studyJournal of Alzheimer's Disease
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Cardiovascular autonomic function and MCI in Parkinson's disease

2019

Abstract Introduction dysautonomic dysfunction and cognitive impairment represent the most disabling non-motor features of Parkinson's Disease (PD). Recent evidences suggest the association between Orthostatic Hypotension (OH) and PD-Dementia. However, little is known on the interactions between cardiovascular dysautonomia and Mild Cognitive Impairment (MCI). We aimed to evaluate the association between cardiovascular dysautonomia and MCI in patients with PD. Methods non-demented PD patients belonging to the PACOS cohort underwent a comprehensive instrumental neurovegetative assessment including the study of both parasympathetic and sympathetic function (30:15 ratio, Expiratory-Inspiratory …

Male0301 basic medicineAutonomic functionmedicine.medical_specialtyAutonomic systemParkinson's diseaseParkinson's diseasePrimary DysautonomiasDiseaseHypotension Orthostatic03 medical and health sciencesOrthostatic vital signs0302 clinical medicineInternal medicineHumansMedicineCognitive DysfunctionCognitive impairmentAgedRetrospective Studiesbusiness.industryMild cognitive impairmentDysautonomiaParkinson DiseaseMiddle Agedmedicine.disease030104 developmental biologyNeurologyCohortCardiologyFemaleCardiovascular dysautonomiaNeurology (clinical)Level iiGeriatrics and Gerontologymedicine.symptombusiness030217 neurology & neurosurgery
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Mild cognitive impairment is associated with fall-related injury among adults aged ≥65 years in low- and middle-income countries.

2021

Abstract Objectives There is a scarcity of data on the association between mild cognitive impairment (MCI) and falls, especially from low- and middle-income countries (LMICs) where 70% of all older adults reside. Thus, we investigated the association between MCI and fall-related injury among older adults residing in six LMICs (China, Ghana, India, Mexico, Russia, South Africa). Design Cross-sectional, community-based data from the WHO Study on global AGEing and adult health (SAGE) were analyzed. Methods The definition of MCI was based on the National Institute on Ageing-Alzheimer's Association criteria, and information on past 12-month fall-related injury was also collected. Multivariable l…

Male0301 basic medicineChinaAgingIndiaPoison controlLogistic regressionGhanaBiochemistrySuicide preventionOccupational safety and healthRussiaOdds*Low-and-middle-income countriesSouth Africa03 medical and health sciencesOlder adults.0302 clinical medicineEndocrinologyRisk FactorsFall-related injuryInjury preventionmental disorders*Fall-related injuryPrevalenceGeneticsHumansMedicine*Mild cognitive impairmentCognitive DysfunctionDeveloping CountriesMexicoMolecular BiologyAged*Older adultsbusiness.industryConfoundingMild cognitive impairmentHuman factors and ergonomicsSmith L. Jacob L. Kostev K. Butler L. Barnett Y. Pfeifer B. Soysal P. Grabovac I. López-Sánchez G. F. Veronese N. et al. -Mild cognitive impairment is associated with fall-related injury among adults aged ≥65 years in low- and middle-income countries.- Experimental gerontology ss.111222 2020Cell BiologyCross-Sectional Studies030104 developmental biologyLow-and-middle-income countrieAccidental FallsFemalebusiness030217 neurology & neurosurgeryDemography
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Milk and Dairy Products Intake Is Related to Cognitive Impairment at Baseline in Predimed Plus Trial

2021

Scope: To examine the association between milk and dairy products intake and the prevalence of cognitive decline among Spanish individuals at high cardiovascular risk. Methods and results: Cross-sectional analyses are performed on baseline data from 6744 adults (aged 55-75 years old). Intake of milk and dairy products is estimated using a food frequency questionnaire grouped into quartiles. The risk of developing cognitive impairment is based on the Mini-Mental State Examination (MMSE). A higher prevalence of cognitive decline was found in subjects who consumed more grams. Patients with worse MMSE score (10-24) consumed a mean of 395.14 ± 12.21 g, while patients with better MMSE score (27-3…

Male0301 basic medicineConsumptionCultured Milk ProductsCognitive declinePositive correlation03 medical and health sciencesCognitionAnimalsHumansMedicineCognitive DysfunctionCognitive declineCognitive impairmentAged2. Zero hunger030109 nutrition & dieteticsbusiness.industryCognitionBaseline dataMiddle AgedPredimedWhole milkCross-Sectional StudiesMilk030104 developmental biologyQuartileFemaleDairy ProductsbusinessFood ScienceBiotechnologyDemographyMolecular Nutrition & Food Research
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Cognitive impairment and levodopa induced dyskinesia in Parkinson’s disease: a longitudinal study from the PACOS cohort

2021

AbstractAim of the study was to evaluate possible associations between cognitive dysfunctions and development of Levodopa Induced Dyskinesia (LID). PD patients from the Parkinson’s disease Cognitive impairment Study cohort who underwent a baseline and follow-up neuropsychological evaluations were enrolled. Mild Cognitive Impairment (PD-MCI) was diagnosed according to MDS level II criteria. The following cognitive domains were evaluated: episodic memory, attention, executive function, visuo-spatial function and language. A domain was considered as impaired when the subject scored 2 standard deviation below normality cut-off values in at least one test for each domain. Levodopa equivalent dos…

Male0301 basic medicineDyskinesia Drug-InducedLevodopamedicine.medical_specialtyParkinson's diseaseScienceNeuropsychological TestsSeverity of Illness IndexArticleCohort StudiesLevodopaExecutive Function03 medical and health sciences0302 clinical medicineInternal medicinemedicineHumansAttentionCognitive DysfunctionLongitudinal StudiesAgedProportional Hazards ModelsLevodopa-induced dyskinesiaMultidisciplinarybusiness.industryQRNeuropsychologyParkinson DiseaseCognitionMiddle Agedmedicine.diseaseAged Attention Cognitive Dysfunction Cohort Studies Dyskinesia Drug-Induced Executive Function Female Humans Levodopa Longitudinal Studies Male Middle Aged Neuropsychological Tests Parkinson Disease Proportional Hazards Models Severity of Illness Index030104 developmental biologyNeurologyRisk factorsDyskinesiaCohortMedicineFemalemedicine.symptombusiness030217 neurology & neurosurgerymedicine.drugCohort studyScientific Reports
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The relationship between Polypharmacy and Trajectories of Cognitive Decline in People with Dementia: a large representative cohort study

2019

Polypharmacy, defined through the number of medications prescribed, has been linked to a range of adverse health outcomes in people with dementia. It is however unclear whether a numerical threshold of concurrently prescribed drugs is a suitable predictor for cognitive decline. We aimed to test associations between polypharmacy and both short-term (six months) and long-term (three years) cognitive trajectories in patients with incident dementia. Using data from a large mental health and dementia care database in South London, a cohort of 12,148 patients (mean age = 80.7 years, 61.1% female, mean MMSE = 18.6) clinically diagnosed with dementia was identified. We determined the number of medi…

Male0301 basic medicineGerontologyAgingCognitive declineBiochemistryCohort Studies03 medical and health sciencesCognitionCommunity care0302 clinical medicineEndocrinologyA large representative cohort study.- Experimental gerontology cilt.120 ss.62-67 2019 [Soysal P. Perera G. Isik A. Onder G. Petrovic M. Cherubini A. Maggi S. Shetty H. Molokhia M. Smith L. et al. -The relationship between polypharmacy and trajectories of cognitive decline in people with dementia]mental disordersGeneticsmedicineHumansDementiaCognitive DysfunctionCognitive declineassociations between polypharmacyMolecular BiologyAgedAged 80 and overPolypharmacypeople with dementia.Mini–Mental State Examinationmedicine.diagnostic_testbusiness.industryCognition; Cognitive decline; Community care; Dementia; PolypharmacyCognitionlong-term (three years)Cell BiologyMental Status and Dementia Testsmedicine.diseaseComorbidity030104 developmental biologyCohortPolypharmacyFemaleDementiabusinessshort-term (six months)030217 neurology & neurosurgeryCohort study
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Impact of Resilience on the Association Between Amyloid-β and Longitudinal Cognitive Decline in Cognitively Healthy Older Adults

2019

The present study aims at investigating if the association between amyloid-β and longitudinal cognitive decline in cognitively healthy elderly is modulated by resilience capacity. Resilience capacity was quantified by education, which is a common proxy of resilience and has been shown to be related to a wide range of behaviors promoting resilience. Analyses were conducted with longitudinal cognitive data from the Alzheimer's Disease Neuroimaging Initiative (ADNI). 276 cognitively healthy older individuals (≥56 years) were included in the study. Baseline amyloid pathology was quantified using CSF amyloid-β 1-42 measurements. Longitudinal cognitive decline was assessed using ADAS13, Clinical …

Male0301 basic medicineGerontologyAmyloid pathologyAmyloid βClinical Dementia RatingDiseaseNeuropsychological Tests03 medical and health sciences0302 clinical medicineNeuroimagingAlzheimer Diseasemental disordersHumansMedicineCognitive DysfunctionLongitudinal StudiesCognitive declineAgedAged 80 and overAmyloid beta-Peptidesbusiness.industryGeneral NeuroscienceCognitionGeneral MedicineMiddle AgedResilience PsychologicalPeptide FragmentsPsychiatry and Mental healthClinical Psychology030104 developmental biologyMixed effectsFemaleGeriatrics and GerontologybusinessBiomarkers030217 neurology & neurosurgeryFollow-Up StudiesJournal of Alzheimer's Disease
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Analysis of Functional and Cognitive Impairment in Institutionalized Individuals with Movement Disorders

2018

Background: Many neurological disorders lead to institutionalization and can be accompanied in their advanced stages by functional impairment, and progressive loss of mobility, and cognitive alterations. Objective: We analyzed the relationship between functional impairment and cognitive performance and its related subdomains in individuals with Parkinson’s disease, Alzheimer’s disease accompanied by motor dysfunction, and with other neurological disorders characterized by both motor and cognitive problems. Methods: All participants lived in nursing homes (Valencia, Spain) and underwent cognitive evaluation with the Mini-Mental State Examination; functional assessment of independence in act…

Male0301 basic medicineMovement disordersActivities of daily livingParkinson's diseaseEndocrinology Diabetes and MetabolismOverweight03 medical and health sciences0302 clinical medicinemedicineHomes for the AgedHumansImmunology and AllergyMemory impairmentCognitive DysfunctionEffects of sleep deprivation on cognitive performanceAgedAged 80 and overCognitive evaluation theoryMovement Disordersbusiness.industryInstitutionalizationCognitionMental Status and Dementia Testsmedicine.diseaseNursing Homes030104 developmental biologySpainFemalemedicine.symptombusiness030217 neurology & neurosurgeryClinical psychologyEndocrine, Metabolic & Immune Disorders - Drug Targets
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Comparing the Effect of Interference on an Emotional Stroop Task in Older Adults with and without Alzheimer’s Disease

2020

Background Impairments in the ability to recognize facial affective expressions may lead to social dysfunction and difficulties with interpersonal communication. Objective The objective was to compare the attentional responses on a Stroop emotional task using words and faces by testing whether the two stimuli differ in the degree of interference they produce in patients with Alzheimer's disease (AD). Methods There were 75 participants: 25 healthy older adults, 25 with mild AD, and 25 with moderate AD. A variation of the classic emotional Stroop test was administered. This task combined emotional words (happy or sad) superimposed on facial expressions (happy or sad), where the words were eit…

Male0301 basic medicinemedicine.medical_specialtyEmotionsAutomaticityDiseaseInterpersonal communicationNeuropsychological TestsAudiology03 medical and health sciences0302 clinical medicineAlzheimer DiseaseEmotional Stroop testReaction TimemedicineHumansCognitive DysfunctionValence (psychology)AgedAged 80 and overFacial expressionGeneral NeuroscienceGeneral MedicineMental Status and Dementia TestsFacial ExpressionPsychiatry and Mental healthClinical Psychology030104 developmental biologySocial PerceptionStroop TestFacilitationFemaleGeriatrics and GerontologyPsychology030217 neurology & neurosurgeryStroop effectJournal of Alzheimer's Disease
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