Search results for "Compact"
showing 10 items of 531 documents
Selective α-synuclein knockdown in monoamine neurons by intranasal oligonucleotide delivery: potential therapy for parkinson’s disease
2018
Progressive neuronal death in brainstem nuclei and widespread accumulation of α-synuclein are neuropathological hallmarks of Parkinson’s disease (PD). Reduction of α-synuclein levels is therefore a potential therapy for PD. However, because α-synuclein is essential for neuronal development and function, α-synuclein elimination would dramatically impact brain function. We previously developed conjugated small interfering RNA (siRNA) sequences that selectively target serotonin (5-HT) or norepinephrine (NE) neurons after intranasal administration. Here, we used this strategy to conjugate inhibitory oligonucleotides, siRNA and antisense oligonucleotide (ASO), with the triple monoamine reuptake …
Lateral Habenula 5-HT2C Receptor Function Is Altered by Acute and Chronic Nicotine Exposures
2021
Serotonin (5-HT) is important in some nicotine actions in the CNS. Among all the 5-HT receptors (5-HTRs), the 5-HT2CR has emerged as a promising drug target for smoking cessation. The 5-HT2CRs within the lateral habenula (LHb) may be crucial for nicotine addiction. Here we showed that after acute nicotine tartrate (2 mg/kg, i.p.) exposure, the 5-HT2CR agonist Ro 60-0175 (5–640 µg/kg, i.v.) increased the electrical activity of 42% of the LHb recorded neurons in vivo in rats. Conversely, after chronic nicotine treatment (6 mg/kg/day, i.p., for 14 days), Ro 60-0175 was incapable of affecting the LHb neuronal discharge. Moreover, acute nicotine exposure increased the 5-HT2CR-immunoreactive (IR)…
On the existence of at least a solution for functional integral equations via measure of noncompactness
2017
In this article, we use fixed-point methods and measure of noncompactness theory to focus on the problem of establishing the existence of at least a solution for the following functional integral equation ¶ \[u(t)=g(t,u(t))+\int_{0}^{t}G(t,s,u(s))\,ds,\quad t\in{[0,+\infty[},\] in the space of all bounded and continuous real functions on $\mathbb{R}_{+}$ , under suitable assumptions on $g$ and $G$ . Also, we establish an extension of Darbo’s fixed-point theorem and discuss some consequences.
Wind accretion in the massive X-ray binary 4U 2206+54: abnormally slow wind and a moderately eccentric orbit
2006
Massive X-ray binaries are usually classified depending on the properties of the donor star in classical, supergiant and Be X-ray binaries. The massive X-ray binary 4U 2206+54 does not fit in any of these groups, and deserves a detailed study to understand how the transfer of matter and the accretion on to the compact object take place. To this end we study an IUE spectrum of the donor and obtain a wind terminal velocity (v_inf) of ~350 km/s, which is abnormally slow for its spectral type. We also analyse here more than 9 years of available RXTE/ASM data. We study the long-term X-ray variability of the source and find it to be similar to that observed in the wind-fed supergiant system Vela …
Electrophysiological and Neurochemical Characterization of 7-Nitroindazole and Molsidomine Acute and Sub-Chronic Administration Effects in the Dopami…
2009
Nitric oxide (NO) plays an important role in the integration of information processed by the basal ganglia nuclei. Accordingly, considerable evidence has emerged indicating a role for NO in pathophysiological conditions such as Parkinson’s disease (PD) and other neurodegenerative disorders. Despite these recent advances, the nitrergic modulation of the dopamine (DA) nigrostriatal system is still unclear. In order to fill this gap, in this study we used in vivo electrophysiology and ex vivo neurochemical analysis to further investigate the effect of NO signaling in rat substantia nigra pars compacta (SNc) and the striatum. Acute and subchronic (4 days) pharmacological manipulation of the NO …
Kurzweil-Henstock type integral on zero-dimensional group and some of its application
2008
A Kurzweil-Henstock type integral on a zero-dimensional abelian group is used to recover by generalized Fourier formulas the coefficients of the series with respect to the characters of such groups, in the compact case, and to obtain an inversion formula for multiplicative integral transforms, in the locally compact case.
Mechanical, thermal and acoustical characterizations of an insulating bio-based composite made from sunflower stalks particles and chitosan
2014
International audience; This study has for objective the determination of thermal, mechanical and acoustical properties of insulating bio-based composite made with chitosan and sunflower's stalks particles. An experimental design was established to find the size grading of particles, the ratio chitosan/sunflower particles and the stress of compaction influencing the thermal and mechanical properties. Composites with a thermal conductivity $(\kappa)$ of 0.056 W/m/K, a maximum stress $(\sigma_{\text{max}})$ of 2 MPa and an acoustic coefficient of absorption $(\alpha)$ of 0.2 were obtained with a ratio of chitosan of 4.3% (w/w) and a size grading of particles higher to 3 mm. These mechanical a…
Characterization and Tuning of Ultra High Gradient Permanent Magnet Quadrupoles
2009
The application of quadrupole devices with high field gradients and small apertures requires precise control over higher order multipole field components. We present a new scheme for performance control and tuning, which allows the illumination of most of the quadrupole device aperture because of the reduction of higher order field components. Consequently, the size of the aperture can be minimized to match the beam size achieving field gradients of up to $500\text{ }\text{ }\mathrm{T}\text{ }{\mathrm{m}}^{\ensuremath{-}1}$ at good imaging quality. The characterization method based on a Hall probe measurement and a Fourier analysis was confirmed using the high quality electron beam at the M…
Supraventricular arrhythmias in noncompaction of left ventricle: Is this a frequent complication?
2008
Background: Isolated left ventricular noncompaction is the result of incomplete myocardial morphogenesis, leading to persistence of the embryonic myocardium. The condition is recognised by an excessively prominent trabecular meshwork and deep intertrabecular recesses of the left ventricle. Whether these intertrabecular recesses are a favorable substrate for supraventricular arrhythmias is unclear, even if the incidence of chronic heart failure seems to be high. Results: We evaluated a continuous series of 238 patients affected by noncompaction. In 4 cases the patients reported palpitations and in 4 an episode of syncope. Periodic holter monitoring was performed every 6 months for 4 years. O…
Ventricular tachycardia in non-compaction of left ventricle: Is this a frequent complication?
2007
Background: Isolated left ventricular non-compaction is the result of incomplete myocardial morphogenesis, leading to persistence of the embryonic myocardium. The condition is recognized by an excessively prominent trabecular meshwork and deep intertrabecular recesses of the left ventricle. Whether these intertrabecular recesses are a favorable substrate for ventricular arrhythmias is unclear. Some reports have found that the fatal ventricular arrhythmias may occur in approximately half of the patients. In this report we investigated about this association. Methods and Results: In total we evaluated a continuous series of 238 patients affected by non-compaction. Periodic Holter monitoring w…