Search results for "Computer Science Application"

An algebraic multigrid based shifted-Laplacian preconditioner for the Helmholtz equation

2007

A preconditioner defined by an algebraic multigrid cycle for a damped Helmholtz operator is proposed for the Helmholtz equation. This approach is well suited for acoustic scattering problems in complicated computational domains and with varying material properties. The spectral properties of the preconditioned systems and the convergence of the GMRES method are studied with linear, quadratic, and cubic finite element discretizations. Numerical experiments are performed with two-dimensional problems describing acoustic scattering in a cross-section of a car cabin and in a layered medium. Asymptotically the number of iterations grows linearly with respect to the frequency while for lower freq…

A damping preconditioner for time-harmonic wave equations in fluid and elastic material

2009

A physical damping is considered as a preconditioning technique for acoustic and elastic wave scattering. The earlier preconditioners for the Helmholtz equation are generalized for elastic materials and three-dimensional domains. An algebraic multigrid method is used in approximating the inverse of damped operators. Several numerical experiments demonstrate the behavior of the method in complicated two-dimensional and three-dimensional domains. peerReviewed

dIvergEnt: How IgE Axis Contributes to the Continuum of Allergic Asthma and Anti-IgE Therapies

2017

[EN] Asthma is an airway disease characterised by chronic inflammation with intermittent or permanent symptoms including wheezing, shortness of breath, chest tightness, and cough, which vary in terms of their occurrence, frequency, and intensity. The most common associated feature in the airways of patients with asthma is airway inflammation. In recent decades, efforts have been made to characterise the heterogeneous clinical nature of asthma. The interest in improving the definitions of asthma phenotypes and endotypes is growing, although these classifications do not always correlate with prognosis nor are always appropriate therapeutic approaches. Attempts have been made to identify the m…

Biomarkers Related to Synaptic Dysfunction to Discriminate Alzheimer’s Disease from Other Neurological Disorders

2022

Recently, the synaptic proteins neurogranin (Ng) and α-synuclein (α-Syn) have attracted scientific interest as potential biomarkers for synaptic dysfunction in neurodegenerative diseases. In this study, we measured the CSF Ng and α-Syn concentrations in patients affected by AD (n = 69), non-AD neurodegenerative disorders (n-AD = 50) and non-degenerative disorders (n-ND, n = 98). The concentrations of CSF Ng and α-Syn were significantly higher in AD than in n-AD and n-ND. Moreover, the Aβ42/Ng and Aβ42/α-Syn ratios showed statistically significant differences between groups and discriminated AD patients from n-AD patients, better than Ng or α-Syn…

An AmI-Based Software Architecture Enabling Evolutionary Computation in Blended Commerce: The Shopping Plan Application

2015

This work describes an approach to synergistically exploit ambient intelligence technologies, mobile devices, and evolutionary computation in order to support blended commerce or ubiquitous commerce scenarios. The work proposes a software architecture consisting of three main components: linked data for e-commerce, cloud-based services, and mobile apps. The three components implement a scenario where a shopping mall is presented as an intelligent environment in which customers use NFC capabilities of their smartphones in order to handle e-coupons produced, suggested, and consumed by the abovesaid environment. The main function of the intelligent environment is to help customers define shopp…

Topological Approach to Analgesia

1994

Mitigating DDoS using weight‐based geographical clustering

2020

Distributed denial of service (DDoS) attacks have for the last two decades been among the greatest threats facing the internet infrastructure. Mitigating DDoS attacks is a particularly challenging task as an attacker tries to conceal a huge amount of traffic inside a legitimate traffic flow. This article proposes to use data mining approaches to find unique hidden data structures which are able to characterize the normal traffic flow. This will serve as a mean for filtering illegitimate traffic under DDoS attacks. In this endeavor, we devise three algorithms built on previously uncharted areas within mitigation techniques where clustering techniques are used to create geographical clusters …

The cryogenic anticoincidence detector for ATHENA-XMS: preliminary results from the new prototype

2012

ATHENA has been the re-scoped IXO mission, and one of the foreseen focal plane instrument was the X-ray Microcalorimeter Spectrometer (XMS) working in the energy range 0.3-10 keV, which was a kilo-pixel array based on TES (Transition Edge Sensor) detectors. The need of an anticoincidence (AC) detector is legitimated by the results performed with GEANT4 simulations about the impact of the non x-ray background onto XMS at L2 orbit (REQ. < 0.02 cts/cm2/s/keV). Our consortium has both developed and tested several samples, with increasing area, in order to match the large area of the XMS (64 mm2). Here we show the preliminary results from the last prototype. The results achieved in this work off…

Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials

2021

Medicinal mushrooms have important health benefits and exhibit a broad spectrum of pharmacological activities, including antiallergic, antibacterial, antifungal, anti-inflammatory, antioxidative, antiviral, cytotoxic, immunomodulating, antidepressive, antihyperlipidemic, antidiabetic, digestive, hepatoprotective, neuroprotective, nephroprotective, osteoprotective, and hypotensive activities. The growing interest in mycotherapy requires a strong commitment from the scientific community to expand clinical trials and to propose supplements of safe origin and genetic purity. Bioactive compounds of selected medicinal mushrooms and their effects and mechanisms in in vitro and in vivo clinical stu…

The New Microtubule-Targeting Agent SIX2G Induces Immunogenic Cell Death in Multiple Myeloma

2022

Microtubule-targeting agents (MTAs) are effective drugs for cancer treatment. A novel diaryl [1,2]oxazole class of compounds binding the colchicine site was synthesized as cis-restricted-combretastatin-A-4-analogue and then chemically modified to have improved solubility and a wider therapeutic index as compared to vinca alkaloids and taxanes. On these bases, a new class of tricyclic compounds, containing the [1,2]oxazole ring and an isoindole moiety, has been synthetized, among which SIX2G emerged as improved MTA. Several findings highlighted the ability of some chemotherapeutics to induce immunogenic cell death (ICD), which is defined by the cell surface translocation of Calreticulin (CAL…