Search results for "Corte"

The Significance of Low O2-Tensi0ns in the Brain Cortex for Occurrence of Metabolic Alterations under Critical Flow Conditions

1985

A reduction in the 02 supply to the brain cortex leads to O2 deficiency and curtailment of neuronal metabolism and function as soon as a minimal cellular O2 tension of 0.1 – 1 mmHG (13 – 133 Pa) can no longer be maintained (Chance et al., 1964; Grote 1967). The hypoxia-induced metabolic alterations are characterized by decreased tissue levels of the energy-rich phosphate compounds PCr and ATP. In addition, elevated concentrations of lactate, pyruvate and NADH and an increase in the lactate/pyruvate ratio and in the NADH/NAD+ ratio are to be expected (Duffy et al., 1972; Granholm and Siesjo 1969; Granholm et al., 1969; Granholm and Siesjo 1971; Grote 1978; Grote and Schubert 1982; Norberg an…

Differential antiepileptic effects of the organic calcium antagonists verapamil and flunarizine in neurons of organotypic neocortical explants from n…

1988

Effects of the organic calcium antagonists verapamil and flunarizine on pentylenetetrazol induced paroxysmal depolarizations were tested in organotypic neocortical explants taken from neonatal rats. In these in vitro experiments the papaverin derivative verapamil depressed, and finally abolished, epileptic discharges in all cases. The piperazine derivative flunarizine, however, which is known to suppress epileptic discharges in hippocampal CA3 neurons (Bingmann and Speckmann 1986), showed no significant antiepileptic effects in the explanted neocortical neurons. Thus, the present findings may indicate that the suppressive action of flunarizine on the generation of paroxysmal depolarizations…

A tale of two palaces and a city: Valencia, 1238-1460

2013

Este artículo estudia las relaciones entre el palacio del Real (Palau del Real), la residencia de los reyes de Aragón en Valencia y la Casa de la Ciudad (Casa de la Ciutat o Sala del Consell) desde la conquista cristiana hasta el final del reinado de Alfonso V el Magnánimo. Durante dos siglos la corte real y el gobierno de la ciudad manifestaron la alianza, la rivalidad y los conflictos a través de la arquitectura y la decoración de sus respectivas sedes. Los emplazamientos, las grandes salas, las capillas con reliquias y las fiestas cívicas desempeñaron un papel notable como instrumentos al servicio tanto de los reyes y sus oficiales como de los consejeros municipales. Aunque ambos palacio…

Neuronal Growth and Behavioral Alterations in Mice Deficient for the Psychiatric Disease-Associated Negr1 Gene

2018

Neuronal growth regulator 1 (NEGR1), a member of the immunoglobulin superfamily cell adhesion molecule subgroup IgLON, has been implicated in neuronal growth and connectivity. In addition, genetic variants in or near the NEGR1 locus have been associated with obesity and more recently with learning difficulties, intellectual disability and psychiatric disorders. However, experimental evidence is lacking to support a possible link between NEGR1, neuronal growth and behavioral abnormalities. Initial expression analysis of NEGR1 mRNA in C57Bl/6 wildtype (WT) mice by in situ hybridization demonstrated marked expression in the entorhinal cortex (EC) and dentate granule cells. In co-cultures of co…

Neuronal Growth and Behavioral Alterations in Mice Deficient for the Psychiatric Disease-Associated

2017

Neuronal growth regulator 1 (NEGR1), a member of the immunoglobulin superfamily cell adhesion molecule subgroup IgLON, has been implicated in neuronal growth and connectivity. In addition, genetic variants in or near the NEGR1 locus have been associated with obesity and more recently with learning difficulties, intellectual disability and psychiatric disorders. However, experimental evidence is lacking to support a possible link between NEGR1, neuronal growth and behavioral abnormalities. Initial expression analysis of NEGR1 mRNA in C57Bl/6 wildtype (WT) mice by in situ hybridization demonstrated marked expression in the entorhinal cortex (EC) and dentate granule cells. In co-cultures of co…

Severe Perinatal Hypoxic-Ischemic Brain Injury Induces Long-Term Sensorimotor Deficits, Anxiety-Like Behaviors and Cognitive Impairment in a Sex-, Ag…

2019

Perinatal brain injury (PBI) leads to neurological disabilities throughout life, from motor deficits, cognitive limitations to severe cerebral palsy. Yet, perinatal brain damage has limited therapeutic outcomes. Besides, the immature brain of premature children is at increased risk of hypoxic/ischemic (HI) injury, with males being more susceptible to it and less responsive to protective/therapeutical interventions. Here, we model in male and female C57BL/6 mice, the impact of neonatal HI and the protective effects of neonatal handling (NH), an early life tactile and proprioceptive sensory stimulation. From postnatal day 1 (PND1, modeling pre-term) to PND21 randomized litters received either…

Regionalisme, pau i seguretat

2012

Xerrada sobre regionalisme, pau i seguretat donada al congrés sobre lleis regionals i internacionals realitzat a València del 13 al 15 de setembre.

Le trattative per le Intese con le Confessioni religiose, tra politica e diritto (osservazioni a margine dell'ordinanza n. 40 del 2015 della Corte co…

2015

THE AMBIGUITIES OF « GRANTED CONSTITUTIONALISM » : A TRANSATLANTIC DEBATE (II)

2017

After France, and before Brazil, the second article concerns Portugal. The portuguese legal framework was appropriate to stem the birth of the constituent power. Reconstructed on the basis of an apocryphal transcription of its founding pact, the Cortes of Lamego of 1143, the portuguese public law benefited on top of a written document born in the XVth century, the Ordenações. This double peculiarity, making "iberian liberties" a model of the ancient constitutionalism, explains the reverential respect for these medieval borders and the hatred following Dom Pedro's granting in 1826. In these conditions, and in spite of the program followed by a "granting power" which refuses to define itself …

Controlli preventivi di legittimità della Corte dei conti e autonomia delle Università

2015

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