Search results for "DISCOVERY"

Trichomonazide Wirkstoffe, 5. Mitt. (Dichloranilino)ethentricarbonitrile

1986

CMPO-substituted calix[6]- and calix[8]arene extractants for the separation of An3+/Ln3+ from radioactive waste

2006

Abstract Three calix[6]arene derivatives ( 1a – c ) and two calix[8]arene derivatives ( 2a , b ), with six and eight CMPO residues, respectively, attached to the narrow/lower rim via ether links, were synthesised. Preliminary liquid–liquid extraction studies for Eu(III) and Am(III) from aqueous nitric acid to o -nitrophenylhexyl ether reveal remarkable properties with respect to efficiency and selectivity, especially for the tert -butylcalix[6]arene derivative with a –(CH 2 ) 3 – spacer.

Antineoplastika, 14. Mitt.1) Cyclohexylderivate der 5-aminomethinylierten Barbitursäure

1983

Aus der mit s-Triazin (1) durchfuhrbaren Aminomethinylierung der 1-Cyclohexyl- (2a) und 1,3-Dicyclohexylbarbitursaure (2b) gehen die korrespondierenden Cyclohexylderivate der 5-aminomethinylierten Barbitursaure 4a und 4b hervor. Insbesondere 4b vermag antineoplastische Effekte auszulosen. Antineoplastic Agents, XIV: Cyclohexyl Derivatives of 5-(Aminomethinyl)-barbituric Acid The aminomethinylation of 1-cyclohexyl- (2a) and 1,3-dicyclohexylbarbituric acid (2b) succeeds by means of s-triazine (1). It leads to the cyclohexyl derivatives 4a and 4b of 5-(aminomethinyl)barbituric acid. Particularly 4b is capable of exerting antineoplastic effects.

Herbizide, 2. Mitt. 2-Trifluormethylpyrimido[1,2-a]benzimidazole

1982

Aus der Kondensation von 2-Aminobenzimidazol (1) mit den Trifluormethyl-β-Diketonen 2a-f gehen die 2-Trifluormethylpyrimido[1,2-a]benzimidazole 3a-f hervor. Auffallende herbizide Wirksamkeit vermag 3a zu entfalten. Herbicides, II: 2-(Trifluoromethyl)pyrimido[1,2-a]benzimidazoles The condensation of 2-aminobenzimidazole (1) with the trifluoromethyl-β-diketones 2a-f furnishes the 2-(trifluoromethyl)pyrimido[1,2-a]benzimidazoles 3a-f. Marked herbicidal activity is exhibited by 3a.

Synthesis of novel 1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolines via benzotriazole methodology

2001

Abstract Pyrroloquinolines have been synthesized reacting 1-(benzotriazol-1(2)-ylmethyl)indolines with unactivated and electron-rich alkenes in the presence of p-toluenesulfonic acid catalyst. Mixtures of the expected diastereomers were obtained and some of them separated in their respective components. X-Ray diffraction along with two-dimensional NMR experiments was needed to assist the determination for both the structures of the precursors and products.

Evidence for the formation of 1,3- and 1,4-dehydrobenzenes in the thermal decomposition of diaryliodonium-carboxylates

1986

Abstract Abstract: Generation of m- and p-benzynes in decomposition of diaryliodonium- 3- and 4-carboxylates is demonstrated by three-phase method.

Synthetic studies toward natural furanosesquiterpenoids from santonin. Synthesis of (+)-1,2-dihydrotubipofuran

1994

Abstract Santonin (1) was converted into (+)-1,2-dihydrotubipofuran (13) via a synthetic pathway involving a very easy preparation of 7,11-ene-8,12-olide and 8,12-furan moieties and A-ring elaboration on the eudesmane framework.

Lactatbildung aus Zuckern und Zuckeralkoholen in Erythrocyten

1965

Erythrocyten konnen Lactat bilden aus Glucose, Fructose, Sorbit, Xylit und Ribit. Mannit wird nicht umgesetzt. Die Kombinationen Xylit + Glucose, Xylit + Fructose und Sorbit + Glucose ergeben additive Lactatbildung. Bei den Kombinationen Xylit + Sorbit, Xylit + Ribit und Glucose + Fructose addiert sich die Lactatbildung nicht. Uber Konsequenzen dieser Befunde fur die parenterale Therapie wird diskutiert.

Inverse correlated 1H-13C in vivo NMR as a probe to follow the metabolism of unlabeled vanillin by plant cell cultures

1997

Abstract Inverse correlated 2D 1H-13C NMR spectroscopy was used to follow the metabolism of vanillin (1) in vivo by plant cell suspension cultures of Nicotiana plumbaginifolia at the natural abundance of 13C. Under the non-invasive conditions four products could be detected: vanillylalcohol (2), vanillinglucoside (3) and the phenolic and benzylic glucosides of vanillylalcohol (4 and 5).

Synthesis of azamacrocycles via a Mitsunobu reaction

2005

Reaction of pernosylated diethylenetriamine and 2-substituted propane-1,3-diols in dry THF in the presence of triphenylphosphine and diisopropyl azodicarboxylate gives the corresponding protected 9-substituted 1,4,7-triazacyclodecanes. The Mitsunobu reaction was also used in the preparation of 3-substituted 1,5,9-triazacyclododecanes and macrocyclic pyridine derivatives.