Search results for "DMA"
showing 10 items of 315 documents
Safety and performance of a suprachoroidal sensor for telemetric measurement of intraocular pressure in the EYEMATE-SC trial
2023
AimTo investigate the safety and performance of a telemetric suprachoroidal intraocular pressure (IOP) sensor (EYEMATE-SC) and the accuracy of its IOP measurements in open angle glaucoma (OAG) patients undergoing simultaneous non-penetrating glaucoma surgery (NPGS).MethodsProspective, multicentre, open-label, single-arm, interventional clinical trial. Twenty-four eyes of 24 patients with OAG regularly scheduled for NPGS (canaloplasty or deep sclerectomy) were simultaneously implanted with an EYEMATE-SC sensor. Six-month follow-up on the sensor’s safety and performance as well as on the level of agreement between the EYEMATE-SC measurements and IOP measurements with Goldmann applanation tono…
Role of FODMAPs in Patients With Irritable Bowel Syndrome: A Review.
2015
Irritable bowel syndrome (IBS) is a condition characterized by abdominal pain, bloating, flatus, and altered bowel habits. The role of dietary components in inducing IBS symptoms is difficult to explore. To date, foods are not considered a cause but rather symptom-triggering factors. Particular interest has been given to the so-called FODMAPs (fermentable oligo-, di-, and monosaccharides and polyols). We aimed to summarize the evidence from the most common approaches to manage suspected food intolerance in IBS, with a particular interest in the role of FODMAPs and the effects of a low FODMAP diet. We reviewed literature, consulting PubMed and Medline by using the search terms FODMAP(s), fru…
Proteomic Analyses Reveal an Acidic Prime Side Specificity for the Astacin Metalloprotease Family Reflected by Physiological Substrates
2011
Astacins are secreted and membrane-bound metalloproteases with clear associations to many important pathological and physiological processes. Yet with only a few substrates described their biological roles are enigmatic. Moreover, the lack of knowledge of astacin cleavage site specificities hampers assay and drug development. Using PICS (proteomic identification of protease cleavage site specificity) and TAILS (terminal amine isotopic labeling of substrates) degradomics approaches >3000 cleavage sites were proteomically identified for five different astacins. Such broad coverage enables family-wide determination of specificities N- and C-terminal to the scissile peptide bond. Remarkably, me…
KPD: An Investigation into the Usability of Knowledge Portal in DMAIC Knowledge Management
2016
Knowledge is considered as a resource that contributes an important role in the success of Six Sigma DMAIC methodology. However, knowledge resides brain of the individuals and exists in various forms and different places. This rise the problem of how to collect and share DMAIC knowledge everywhere all time. In this paper, we introduce a proposed Knowledge Portal named KPD that had been designed as a tool to manage DMAIC knowledge. Through the deployment of the Knowledge Portal, this paper aims at investigating its impacts on DMAIC execution based on experiments and appreciation of experts who are working in the areas of quality management and information technology. The results of the surve…
A Random Extension for Discriminative Dimensionality Reduction and Metric Learning
2009
A recently proposed metric learning algorithm which enforces the optimal discrimination of the different classes is extended and empirically assessed using different kinds of publicly available data. The optimization problem is posed in terms of landmark points and then, a stochastic approach is followed in order to bypass some of the problems of the original algorithm. According to the results, both computational burden and generalization ability are improved while absolute performance results remain almost unchanged.
Lung CT Image Registration through Landmark-constrained Learning with Convolutional Neural Network
2020
Accurate registration of lung computed tomography (CT) image is a significant task in thorax image analysis. Recently deep learning-based medical image registration methods develop fast and achieve promising performance on accuracy and speed. However, most of them learned the deformation field through intensity similarity but ignored the importance of aligning anatomical landmarks (e.g., the branch points of airway and vessels). Accurate alignment of anatomical landmarks is essential for obtaining anatomically correct registration. In this work, we propose landmark constrained learning with a convolutional neural network (CNN) for lung CT registration. Experimental results of 40 lung 3D CT …
Identification of major histocompatibility complex class II-associated peptides derived from freshly prepared rat Langerhans cells using MALDI-PSD an…
2000
The isolation and identification is described of MHC class II-bound peptides derived from Langerhans cells. A combination of preparative micro-HPLC, MALDI-MS, Edman degradation was used for determining the amino acid sequence of MHC-associated peptides. Sample handling was crucial because fractions containing trace amounts of material require immediate storage at −80 °C to prevent peptide losses.
Volatiles in pantellerite magmas: A case study of the Green Tuff Plinian eruption (Island of Pantelleria, Italy)
2013
Abstract The Green Tuff (GT) Plinian eruption, the largest in magnitude at Pantelleria, erupted 3 to 7 km3 DRE of pantellerite magma and a small volume of trachyte. Fifty-nine anorthoclase-hosted melt inclusions from the two basal pumice members were analyzed by FT-IR spectroscopy in order to assess the pre-eruptive H2O content in the pantellerite melt. Microanalytical methods were used to determine major element, Cl, F and S contents. Melt inclusions and glassy groundmasses have a nearly homogeneous pantelleritic composition (peralkaline index = 1.9-2.2) and variable water contents ranging from 1.4 to as high as 4.2 wt %, i.e. much higher than the 1.4 wt % of earlier published studies. The…
Reliability and Intersession Agreement of Microperimetric and Fixation Measurements Obtained with a New Microperimeter in Normal Eyes.
2015
Purpose: To evaluate the reliability and intersession agreement of measurements of retinal sensitivity as well as of the fixation pattern obtained in healthy eyes with a microperimeter integrating the mechanism of the scanning laser ophthalmoscope (SLO) with the static perimetry. Methods: This study included a sample of 44 healthy eyes of 44 subjects of a mean age of 27.0 ± 8.5 years. In all cases, microperimetric exams with the MAIA system (Centervue, Padova, Italy) were performed in three different sessions to evaluate the intersession repeatability. The consistency of measurements was analyzed by using the Friedman test and by analyzing the correlation between consecutive measurements. A…