Search results for "DOMAIN"
showing 10 items of 2485 documents
Regulation of T cells in asthma: implications for genetic manipulation
2004
PURPOSE OF THE REVIEW Allergic asthma is a disease characterized by airway hyperresponsiveness, inflammation and remodeling. In the past few decades it has become clear that the pathogenesis and development of this disease is controlled by cytokines released by CD4 T helper type 2 lymphocytes that develop under the influence of natural killer lymphocytes. At birth, T cell priming exhibits a T helper type 2 bias and the development of the T helper phenotype is determined in the first year of life by environmental exposure to virus or bacterial substances or environmental allergens in genetically predisposed individuals. Decreased exposure to infection in early childhood has thus been linked …
Dominant negative MORT1/FADD rescues mice from CD95 and TNF-induced liver failure
2002
Derangement of the apoptotic program is considered an important cause of liver disease. It became clear that receptor-mediated apoptosis is of specific interest in this context, and CD95 and CD120a, both members of the tumor necrosis factor (TNF) receptor superfamily, are the most prominent cell death receptors involved. The death signal is induced upon ligand binding by recruitment of caspases via the adapter molecule MORT1/FADD to the receptor and their subsequent activation. To investigate the role of MORT1/FADD in hepatocyte apoptosis, we generated transgenic mice expressing liver-specific dominant negative mutant. Mice looked grossly normal; breeding and liver development were not diff…
Extremal Problems for Elliptic Systems
1998
The specific properties of optimal control problems for elliptic systems, if compared with the case of a single equation, are described. Within them are: strong closures of sets of feasible states; the relaxability via convexification; the type of necessary optimality conditions.
Numerical and experimental study of liquid metal stirring by rotating permanent magnets
2018
In this work, we study liquid gallium stirring by rotating permanent magnets. We demonstrate possibility of easily creating different flow patterns by rotating permanent magnets, which can be industrially important for controlling heat and mass transfer processes in the system. Unlike the typical approach of simulating magnet rotation as a transient problem and time-averaging the Lorentz forces, we solve the magnet rotation as a harmonic (frequency domain) problem, which leads to forces equal to time-averaged ones and decreases the simulation time considerably. Numerical results are validated using qualitative flow structure results from the neutron radiography visualization of tracer parti…
Paradigm shift in engineering education More time is needed
2010
Abstract Information Technology (IT) becomes: innovation motor, engineering toolbox; basic part of curricula. The impact on engineering education is due to shifting from industrial towards post-industrial engineering. IT is the most suitable domain to bear the paradigmatic shifts able to lessen the paradox of temporal dissociation between the present process of teaching and its future mirroring in life-long learning. Hence, a modern approach to time and to its related concepts is focused upon. The essence of applying new paradigms in education is exemplified via the advanced subdomain of artificial intelligence. Conclusion: carrying out such educational innovations is urgent, painless and a…
QUALITATIVE RESEARCH IN TRAVEL BEHAVIOR STUDIES
2016
Qualitative methodology is extensively used in a wide range of scientific areas, such as Sociology and Psychology, and it is been used to study individual and household decision making processes. However, in the Transportation Planning and Engineering domain it is still infrequent to find in the travel behavior literature studies using qualitative techniques to explore activity-travel decisions. The aim of this paper is first, to provide an overview of the types of qualitative techniques available and to explore how to correctly implement them. Secondly, to highlight the special characteristics of qualitative methods that make them appropriate to study activity-travel decision processes. Fa…
Inflammasomes in Liver Fibrosis
2017
AbstractCell death and inflammation are two central elements in the development of liver fibrosis. Inflammasomes are intracellular multiprotein complexes expressed in both hepatocytes and nonparenchymal cells in the liver that are key regulators of inflammation and cell fate. They respond to cellular danger signals by activating caspase 1, releasing the proinflammatory cytokines IL-1β and IL-18, as well as initiating a novel pathway of programmed cell death termed “pyroptosis.” These processes can initiate and perpetuate an abnormal wound-healing response with the principle cellular target being the activation of hepatic stellate cells. From the various inflammasomes, the NLRP3 inflammasome…
Liver-specific Ldb1 deletion results in enhanced liver cancer development.
2009
Background & Aims LIM-domain-binding (Ldb) proteins have been demonstrated to be essential not only to key embryonic developmental processes but also to carcinogenesis. We have previously demonstrated Ldb1 to be of high biological and developmental relevance, as a targeted deletion of the Ldb1 gene in mice results in an embryonic lethal and pleiotropic phenotype. Methods We have now established a liver-specific Ldb1 knock out to investigate the role of Ldb1 in carcinogenesis, in particular in hepatocellular carcinoma (HCC) development, in vivo . Results These mice demonstrated a significantly enhanced growth of liver cancer by means of tumor size and number, advocating for an essential role…
UNIQUENESS OF PERIODIC SOLUTIONS OF THE LIENARD EQUATION
1981
This chapter analyzes the uniqueness of periodic solutions of the Lienard equation. It considers the Lienard equation = y − F ( x ) and y = − x where F (0) = 0 , F ( x ) ∈ Lip( R ). The chapter discusses the existence of periodic solutions. It highlights that the origin is the only stationary point of the system = y − F ( x ) and y = − x , and therefore all nontrivial periodic solutions must circle around the origin. The existence of at least one periodic solution is proved by constructing a Poincare–Bendixson domain. The chapter also emphasizes that to prove the uniqueness of periodic solutions, additional assumptions are also needed. In the literature there are numerous uniqueness results…
Local uniqueness of the solutions for a singularly perturbed nonlinear nonautonomous transmission problem
2020
Abstract We consider the Laplace equation in a domain of R n , n ≥ 3 , with a small inclusion of size ϵ . On the boundary of the inclusion we define a nonlinear nonautonomous transmission condition. For ϵ small enough one can prove that the problem has solutions. In this paper, we study the local uniqueness of such solutions.