Search results for "DOMAINS"

Removable sets for Sobolev spaces

1999

We study removable sets for the Sobolev space W1,p. We show that removability for sets lying in a hyperplane is essentially determined by their thickness measured in terms of a concept of p-porosity.

Uniform, Sobolev extension and quasiconformal circle domains

1991

This paper contributes to the theory of uniform domains and Sobolev extension domains. We present new features of these domains and exhibit numerous relations among them. We examine two types of Sobolev extension domains, demonstrate their equivalence for bounded domains and generalize known sufficient geometric conditions for them. We observe that in the plane essentially all of these domains possess the trait that there is a quasiconformal self-homeomorphism of the extended plane which maps a given domain conformally onto a circle domain. We establish a geometric condition enjoyed by these plane domains which characterizes them among all quasicircle domains having no large and no small bo…

Embedding of Sobolev Spaces into Lipschitz Spaces

1989

The main result of the paper is that if Ω is a bounded uniform domain in ℝn and p>n, then the Sobolev space Wl, p(Ω) embeds continously into Cα(Ω), α = 1 - n/p.

ASYMMETRY OF SELECTIVE ATTENTION IN HEALTHY SUBJECTS AND PATIENTS WITH CERVICAL FOCAL DYSTONIA

The environment continuously provides a wealth of information through our senses. This poses a major challenge to our brains to effectively process the relevant pieces of information over space and time, involving attentional processes. Attention selects, modulates and sustains focus on information most relevant for behaviour going beyond our limited capacity to process competing options. Voluntary allocation of attention to features, objects, or regions in space is controlled by top-down mechanisms. On the other hand, salient stimuli can automatically attract attention, even though the subject does not have intentions to attend to these stimuli. A key question is how attention is shaped by…

Magnetic domain-wall racetrack memory for high density and fast data storage

2012

The racetrack memory device is a new concept of Magnetic RAM (MRAM) based on controlling domain wall (DW) motion in ferromagnetic nanowires. It promises ultra-high storage density thanks to the possibility to store multiple narrow DWS per memory cell. By using read and write heads based on magnetic tunnel junctions (MTJ) with perpendicular magnetic anisotropy (PMA) fast data access speed can also be achieved. Thereby the racetrack memory can be used as universal storage to address both embedded and standalone applications. In this paper, we present the device physics, integration circuit and architecture designs of a racetrack memory based on MTJs with PMA. Mixed SPICE simulations at 65 nm …

Thickness measurement of soft thin films on periodically patterned magnetic substrates by phase difference magnetic force microscopy

2013

The need for accurate measurement of the thickness of soft thin films is continuously encouraging the development of techniques suitable for this purpose. We propose a method through which the thickness of the film is deduced from the quantitative measurement of the contrast in the phase images of the sample surface acquired by magnetic force microscopy, provided that the film is deposited on a periodically patterned magnetic substrate. The technique is demonstrated by means of magnetic substrates obtained from standard floppy disks. Colonies of Staphylococcus aureus adherent to such substrates were used to obtain soft layers with limited lateral (a levy microns) and vertical (hundreds of n…

Lipid and phase specificity of α-toxin from S. aureus

2013

AbstractThe pore forming toxin Hla (α-toxin) from Staphylococcus aureus is an important pathogenic factor of the bacterium S. aureus and also a model system for the process of membrane-induced protein oligomerisation and pore formation. It has been shown that binding to lipid membranes at neutral or basic pH requires the presence of a phosphocholine-headgroup. Thus, sphingomyelin and phosphatidylcholine may serve as interaction partners in cellular membranes. Based on earlier studies it has been suggested that rafts of sphingomyelin are particularly efficient in toxin binding. In this study we compared the oligomerisation of Hla on liposomes of various lipid compositions in order to identif…

Echovirus 1 Endocytosis into Caveosomes Requires Lipid Rafts, Dynamin II, and Signaling EventsV⃞

2004

Binding of echovirus 1 (EV1, a nonenveloped RNA virus) to the α2β1 integrin on the cell surface is followed by endocytic internalization of the virus together with the receptor. Here, video-enhanced live microscopy revealed the rapid uptake of fluorescently labeled EV1 into mobile, intracellular structures, positive for green fluorescent protein-tagged caveolin-1. Partial colocalization of EV1 with SV40 (SV40) and cholera toxin, known to traffic via caveosomes, demonstrated that the vesicles were caveosomes. The initiation of EV1 infection was dependent on dynamin II, cholesterol, and protein phosphorylation events. Brefeldin A, a drug that prevents SV40 transport, blocked the EV1 infection…

Surface topography of membrane domains

2010

金沢大学理工研究域数物科学系

Diacylglycerol-containing oleic acid induces increases in [Ca(2+)](i) via TRPC3/6 channels in human T-cells.

2011

Though most of the studies have focused on the effects of free fatty acids on T-cell activation, fatty acids incorporated into plasma membrane phospholipids may also affect cell signaling via diacylglycerol (DAG), generally produced by phospholipid hydrolysis. In the present study, we have synthesized a DAG-containing oleic acid and studied its implication in the modulation of calcium signaling in human Jurkat T-cells. 1-palmitoyl-2-oleoyl-sn-glycerol (POG) induced a dose-dependent increase in [Ca(2+)](i). This effect was due to the presence of oleic acid at the sn-2 position as no differences were observed between POG and 1-stearoly-2-oleoyl-sn-glycerol (SOG). However, the substitution of …