Search results for "Dans"
showing 10 items of 275 documents
Amyloid precursor protein in platelets of patients with Alzheimer disease: effect of acetylcholinesterase inhibitor treatment.
2001
BACKGROUND:Amyloid precursor protein (APP) forms with apparent molecular weights of 130, 110, and 106 kd are present in human platelets. It has been demonstrated that Alzheimer disease (AD) is specifically associated with a decreased APP forms ratio in platelets. OBJECTIVE:To investigate whether acetylcholinesterase (AChE) inhibitor treatment modifies the ratio of platelet APP forms in patients with AD. PATIENTS AND METHODS:From a large sample of patients with probable AD, 30 with mild to moderate AD were selected. Each patient underwent a clinical evaluation including the Mini-Mental State Examination (MMSE) and platelet APP forms analysis at baseline and after 30 days. During this interva…
Continuous flow-injection-atomic absorption spectrometric method for the determination of Ondansetron
1995
Abstract A flow-injection procedure for the indirect determination of the new drug Ondansetron is proposed. The method is based on the reaction of the drug in an oxidative solid-phase reactor included in the flow assembly. The reactor was made by lead dioxide physically entrapped by polymerization; the released lead(II) was monitored by atomic absorption spectrometry at 217.0 nm. The procedure gave a linear calibration graph up to 20 μg ml−1 of Ondansetron with a sample throughput of 338 samples h−1.
Extractive Spectrophotometric Determination of Ondansetron by Ion-Pair Formation with Bromocresol Green
1996
Abstract An empirical spectrophotometric procedure for the determination of the antiemetic ondansetron is carried out. The method is based on the formation of a 1:1 ion pair with bromocresol green in the pH range over 3.2 – 4.4, extraction into chloroform layer and spectrophotometric measurement at 420.8 nm. The calibration graph is linear over the range 0.1 – 20 μg ml−1 ondansetron, with a relative standard deviation of 2.7%; the influence of foreign substances is also studied. The method is applied to ondansetron determination in human urine.
Off-line dansylation of amines using C18 solid-phase packings: study of the fluorescence and chemiluminescence detection by post-column derivatizatio…
1999
Abstract Dansylation of amines (primaries and secondaries) using C18 solid-phase supports is described. The time of analysis and the handing sample have been markedly improved with respect to those required for solution dansylation. The dansylated amine derivates were injected onto the liquid chromatography system and fluorescence detected. The sensitivity and selectivity is better than the other dansylation procedures described in the literature and also better than other derivatization reagents such 1,2-napthoquinone 4-sulfonate (NQS) or 3,5-dinitrobenzoyl chloride (3,5-DNB). Dansyl compounds can also form chemiluminescent derivatives, therefore a post-column derivatization procedure with…
Two heterologously expressed Planobispora rosea proteins cooperatively induce Streptomyces lividans thiostrepton uptake and storage from the extracel…
2010
Abstract Background A bacterial artificial chromosomal library of Planobispora rosea, a genetically intractable actinomycete strain, was constructed using Escherichia coli-Streptomyces artificial chromosome (ESAC) and screened for the presence of genes known to be involved in the biosynthesis of antibiotics. Results One clone with a 40 kb insert showed antimicrobial activity against Gram positive bacteria. Insert sequence analysis and subcloning experiments revealed that the bioactivity was due to a 3.5 kb DNA fragment containing two open reading frames. These orfs encode two proteins with high similarity to a putative membrane protein of Streptomyces coelicolor and to the nogalamycin resis…
Structural characterisation of the natural membrane-bound state of melittin: a fluorescence study of a dansylated analogue
1997
Abstract The binding of a dansylated analogue of melittin (DNC–melittin) to natural membranes is described. The cytolytic peptide from honey bee venom melittin was enzymatically labelled in its glutamine-25 with the fluorescent probe monodansylcadaverine using guinea pig liver transglutaminase. The labelled peptide was characterised functionally in cytolytic assays, and spectroscopically by circular dichroism and fluorescence. The behaviour of DNC–melittin was, in all respects, indistinguishable from that of the naturally occurring peptide. We used resonance energy transfer to measure the state of aggregation of melittin on the membrane plane in synthetic and natural lipid bilayers. When bo…
1206 Comparison of granisetron vs ondansetron vs tropisetron in the prophylaxis of acute nausea and vomiting induced by highly emetogenic chemotherap…
1995
A two-centre prospective randomized open cross-over study to compare granisetron (Gra) vs ondansetron (Ond) vs tropisetron (Tro) in the prevention of high-dose cisplatin-induced nausea and vomiting was carried out. The notable characteristics of our study were: all patients were very homogeneous for tumor site (head and neck cancer), all were treated with high-dose (80 to 100 mg/sqm) cisplatin on day 1 and all were chemotherapy-naive. 141 patients for a total number of 541 chemotherapy cycles containing high-dose cisplatin were randomized to receive 24 mg of Ond intravenously (i.v.) or 3 mg of Gra i.v. or 5 mg of Tro i.v. for the control of acute nausea and emesis. In the Gra group in 138 o…
Gender and anthropometrics of patients undergoing cisplatin-containing chemotherapy as determinants of acute emesis over repeat courses
2002
Objective. To characterize the anthropometric and pharmacotherapeutic variables related to acute emesis over repeat courses of cisplatin-containing regimens (≥50 mg/m survival analysis.2) by means of survival analysis. Methods. A prospective, cross-sectional non-controlled study was started to analyse acute vomiting in patients treated in a general hospital. The patients received an intravenous combination of drugs based on metoclopramide (two 3 mg/kg doses), diphenhydramine (20 mg) and dexamethasone (20 mg) as first choice antiemetic treatment. An intravenous regimen based on ondansetron (8 mg) and dexamethasone (20 mg) was given as an alternative regimen. Therapeutic failure was defined …
Actividad de los músculos paravertebrales durante ejercicios que requieran estabilidad raquídea
2011
CONTEXTO: El entrenamiento aplicando elementos de inestabilidad está siendo ampliamente utilizado en el campo del entrenamiento como una herramienta novedosa y eficaz. No obstante, recientes hallazgos aportan datos contrarios a esta creencia y sugieren que la ejecución de ejercicios tradicionales sobre superficies inestables o ejercicios calisténicos específicos para el fortalecimiento estabilizador pueden no resultar estímulo suficiente para personas con un nivel de entrenamiento elevado llegando incluso a interferencia en el rendimiento final por la reducción de la capacidad de fuerza y la carencia de especificidad del entrenamiento. OBJETIVO: Cuantificar y comparar la actividad muscular …
ChiLab4It system in the QA4FAQ competition
2017
ChiLab4It is the Question Answering system (QA) for Frequently Asked Questions (FAQ) developed by the Computer-Human Interaction Laboratory (ChiLab) at the University of Palermo for participating to the QA4FAQ task at EVALITA 2016 competition. The system is the versioning of the QuASIt framework developed by the same authors, which has been customized to address the particular task. This technical report describes the strategies that have been imported from QuASIt for implementing ChiLab4It, the actual system implementation, and the comparative evaluations with the results of the other participant tools, as provided by the organizers of the task. ChiLab4It was the only system whose score re…