Search results for "Derivative"

The sunset of Gortyn: amphorae in 7th –8th centuries AD

2014

Gortyn (A. Di Vita [ed.] 2000-01), some new contexts, more delimited and reliable, allow us to define better circulation, developments, and local use of amphorae in the last periods of urban life of the Cretan city. Two contexts of the mid-late 7th and late 7th-8th centuries are briefly analysed, coming from different quarters of the town (the Old Agora and the Early Byzantine houses near the “Praetorium”), and resulting from different formative processes, which could represent the circulation trends just before, and in the re-occupation phase after the earthquake that dismembered the Late Roman urban layout at the end of the 7th/early 8th century. They display a variety of imports from tra…

Zur Gelpermeationschromatographie in organischen Lösungsmitteln

1965

Die Gelpermeationschromatographie hat sich vor allem mittels der Sephadexgele fur die Trennung polymerhomologer wasserloslicher Makromolekule als sehr erfolgreich erwiesen. Die Trennung nur in organischen Losungsmitteln loslicher Polymerer ist erst in jungster Zeit gelungen, wobei vernetzte Polystyrol-, Polymethacrylat- und Dextranderivatgele benutzt werden. Der Mechanismus dieses chromatographischen Prozesses wird untersucht. Ein Vergleich dieses Vorganges, bei dem das Polymere nur in einer Phase vorliegt, mit den klassischen Methoden, die mit Auftrennung in zwei Phasen arbeiten, wird durchgefuhrt. Insbesondere werden die Methoden der Dreiecks-Fallungsfraktionierung, der Kolonnentechnik mi…

Synthesis of Enaminones-Based Benzo[d]imidazole Scaffold: Characterization and Molecular Insight Structure

2020

(E)-1-(1H-Benzo[d]imidazol-2-yl)-3-(dimethylamino)prop-2-en-1-one 2 was synthesized by one-pot synthesis protocol of 2-acetyl benzo[d]imidazole with dimethylformamide dimethylacetal (DMF-DMA) in xylene at 140 &deg

BODIPY dyes functionalized with 2-(2-dimethylaminophenyl)ethanol moieties as selective OFF–ON fluorescent chemodosimeters for the nerve agent mimics …

2014

[EN] Two OFF-ON fluorescent chemodosimeters based on a BODIPY core for the detection of nerve agent mimics have been synthesized. Their reactivity towards diethylcyanophosphonate (DCNP) and diisopropylfluorophosphate (DFP) has been tested in organic and aqueous phase. These chemodosimeters selectively detect the nerve agent mimics with good LODs. The chemodosimeters hold their sensing properties on solid supports, allowing the preparation of a hand held sensing kit. The sensing in solid-liquid phase has been demonstrated. The X-ray structure of compound 2 has been resolved.

2017

The energy levels of the HOMO/LUMO Frontier orbitals and the electronic properties of phthalocyanine macrocycles can be tuned by the introduction of substituents. Starting from tetrafluorophthalonitrile, we studied the substitution of fluorine atoms by (2-thienyl)ethoxy moieties. An optimization of the experimental conditions (nature and stoichiometry of the alcohol and base, temperature) allowed us to obtain the monoalkoxy derivative with a very good yield. It was fully characterized using 19F and 1H NMR spectroscopies, thermal analysis and X-ray diffraction on single crystals. Then, the corresponding zinc phthalocyanine was synthesized, characterized by means of 19F and 1H NMR spectroscop…

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)-s-triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Sign…

2022

Here, we synthesized a newseries of mono- and bis(dimethylpyrazolyl)-s-triazine derivatives. The synthetic methodology involved the reaction of different mono- and dihydrazinyl-s-triazine derivatives with acetylacetone in the presence of triethylamine to produce the corresponding target products in high yield and purity. The antiproliferative activity of the novel mono- and bis(dimethylpyrazolyl)-s-triazine derivatives was studied against three cancer cell lines, namely, MCF-7, HCT-116, and HepG2. N-(4-Bromophenyl)-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-morpholino-1,3,5-triazin-2-amine 4f, N-(4-chlorophenyl)-4,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,3,5-triazin-2-amine 5c, and 4,6-bis(3,5-dimethy…

The $p\lambda n$ fractal decomposition: Nontrivial partitions of conserved physical quantities

2015

A mathematical method for constructing fractal curves and surfaces, termed the $p\lambda n$ fractal decomposition, is presented. It allows any function to be split into a finite set of fractal discontinuous functions whose sum is equal everywhere to the original function. Thus, the method is specially suited for constructing families of fractal objects arising from a conserved physical quantity, the decomposition yielding an exact partition of the quantity in question. Most prominent classes of examples are provided by Hamiltonians and partition functions of statistical ensembles: By using this method, any such function can be decomposed in the ordinary sum of a specified number of terms (g…

How amino and nitro substituents affect the aromaticity of benzene ring

2020

Abstract The effect of strongly electron-accepting and electron-donating substituents on the aromaticity of the benzene ring has been revealed based on experimental and computational data. It has been documented that the nitro group affects the π-electron structure of the ring in its benzene derivative ca. 2.8 times weaker than the amino group. However, their joint effects in the meta and para nitroaniline, compared to nitrobenzene, results in a decrease of the delocalization in the ring by a factor ca. 4.0 and 6.5, respectively.

Squaric Acid Mediated Synthesis and Biological Activity of a Library of Linear and Hyperbranched Poly(Glycerol)-Protein Conjugates

2012

Polymer-protein conjugates generated from side chain functional synthetic polymers are attractive because they can be easily further modified with, for example, labeling groups or targeting ligands. The residue specific modification of proteins with side chain functional synthetic polymers using the traditional coupling strategies may be compromised due to the nonorthogonality of the side-chain and chain-end functional groups of the synthetic polymer, which may lead to side reactions. This study explores the feasibility of the squaric acid diethyl ester mediated coupling as an amine selective, hydroxyl tolerant, and hydrolysis insensitive route for the preparation of side-chain functional, …

Beyond Poly(ethylene glycol): Linear Polyglycerol as a Multifunctional Polyether for Biomedical and Pharmaceutical Applications

2014

Polyglycerols (sometimes also called "polyglycidols") represent a class of highly biocompatible and multihydroxy-functional polymers that may be considered as a multifunctional analogue of poly(ethylene glycol) (PEG). Various architectures based on a polyglycerol scaffold are feasible depending on the monomer employed. While polymerization of glycidol leads to hyperbranched polyglycerols, the precisely defined linear analogue is obtained by using suitably protected glycidol as a monomer, followed by removal of the protective group in a postpolymerization step. This review summarizes the properties and synthetic approaches toward linear polyglycerols (linPG), which are at present mainly base…