Search results for "Dermatology"

Immunoadsorption for treatment of severe atopic dermatitis.

2017

Atopic dermatitis (AD) is a common disease affecting up to 10-20% of the population with the largest disease burden in childhood. Treatment options include basic emollient treatment, topical as well as systemic immunosuppressants. The pathogenesis is complex and among various triggers, genetic predisposition and immunological alterations contribute to development of disease. Atopy is common in patients with AD and many patients have high levels of Immunoglobulin E (IgE), some of which recognizes exogenous or auto/self-allergens. Treatment options targeting IgE such as specific immunotherapy against e.g. house dust mites or using anti-IgE antibodies (omalizumab) showed variable results that …

Cutaneous manifestations of polycystic ovary syndrome

2020

Abstract Hirsutism, acne, and/or female pattern hair loss are common cutaneous manifestations of polycystic ovary syndrome (PCOS). However, while hirsutism is mainly related to androgen excess, both acne and female pattern hair loss may often depend on cutaneous alterations that are not linked to hyperandrogenism or increased androgen sensitivity. Because both acne and female pattern hair loss cannot be considered a sign of hyperandrogenism, neither should be included in the diagnostic process of PCOS without demonstration of increased levels of circulating androgens. In addition, in patients with androgen-dependent acne, the concomitant proliferation of Propionibacterium acnes in skin may …

The Antiviral Properties of Cyclosporine. Focus on Coronavirus, Hepatitis C Virus, Influenza Virus, and Human Immunodeficiency Virus Infections

2020

This review updates current knowledge regarding the risk of viral infections, including COVID-19, in patients treated with cyclosporine. We also shortly refer to bacterial infections and parasitic infestations in patients treated with cyclosporin. Cyclosporine is an immunosuppressive drug, which is widely used in medicine, including in the treatment of autoimmune skin diseases in dermatology, rheumatology, ophthalmology and nephrology, and in organ transplantation. A usual concern associated with immunosuppressive treatment is the potential risk of infections. Interestingly, several data indicate a relatively low risk of infections, especially viral infections, in patients receiving cyclosp…

Insufficient generation of Th17 cells in IL-23p19-deficient BALB/c mice protects against progressive cutaneous leishmaniasis

2017

Healing of leishmaniasis-a parasitic skin disease-is associated with high levels of secreted interferon (IFN)γ and IL-12 in resistant C57BL/6 mice and humans. Susceptible BALB/c mice predominantly react with a Th17/Th2/Treg-related immune response and finally succumb to infection. Previously, we showed that BALB/c IL-17A-/- mice are protected against Leishmania (L.) major infections, indicating that IL-17A-predominantly produced by Th17 cells-plays an important role for disease outcome. We now investigated DC-derived cytokines and finally identified IL-23p19 as key cytokine responsible for induction of Leishmania-specific Th17 cells that play an important role for progressive disease in sus…

Postzygotic BRAF p.Lys601Asn Mutation in Phacomatosis Pigmentokeratotica with Woolly Hair Nevus and Focal Cortical Dysplasia

2016

International audience

Ammonium thiolactate and thiolactic acid: important hairdressers' allergens?

2002

Giant cell arteritis (Horton's disease) in very elderly patients aged 80 years and older: A study of 25 cases

2015

Aim Analysis of the characteristics of very elderly patients with giant cell arteritis (GCA). Methods Patients aged 80 years and older diagnosed with GCA in our department between 1 January 2002 and 31 July 2008 were retrospectively included. For each patient, we recorded general characteristics, reason(s) for hospitalization, specialty of the physician or department that referred the patient to us, medical history, treatment at admission, GCA clinical features, time to diagnosis of GCA, biological screening and GCA treatment. Results We analyzed 25 clinical records, 18 women and seven men with a mean age of 83.9 years. General weakness, visual loss and inflammatory syndrome were the princi…

Real-life practice: rapid improvement in itch symptomatology in patients with atopic dermatitis treated with dupilumab

2019

Sir,Atopic dermatitis is a chronic relapsing inflammatory skin disorder that affects up to 20% of children and 2–5% of the adult population (1). The disease is characterized by erythematous, xeroti...

Contenidos fundamentales de la Dermatología en el grado de medicina en España. Recomendaciones del grupo de profesores de la Academia Española de Der…

2016

Antecedentes: Los problemas dermatologicos constituyen uno de los motivos de consulta masfrecuentes en atencion primaria. En los ultimos a˜nos, como consecuencia de la adaptacion alespacio europeo de educacion superior, en muchos planes de estudios se ha reducido el tiempodestinado al aprendizaje de la dermatologia.Material y metodos:Para consensuar los contenidos basicos del programa de dermatologia enel pregrado, se remitio electronicamente una encuesta a los 57 miembros de grupo de profeso-res de la Academia Espa˜nola de Dermatologia y Venereologia para establecer cuales deberianser los objetivos de aprendizaje de la asignatura en Espa˜na. Se incluyeron 131 objetivos previa-mente selecci…

Deux observations de granulome annulaire sous anti-PD1

2017

Resume Introduction Le granulome annulaire fait partie des reactions granulomateuses qui peuvent etre induites par des medicaments. L’immunotherapie par anti-PD1 est utilisee dans le traitement des melanomes et d’autres cancers solides. Nous rapportons deux cas de granulome annulaire survenus chez des patientes traitees par un anti-PD1, le pembrolizumab. Observations Deux femmes traitees par pembrolizumab toutes les 3 semaines pour un melanome metastatique ont developpe un granulome annulaire sous traitement. L’immunotherapie a ete maintenue dans les deux cas. Les lesions ont continue d’evoluer par poussees et remissions chez la premiere patiente, alors qu’une disparition complete etait con…