Search results for "Development"

Approche qualitative et phénoménologique du premier épisode psychotique : vécu traumatique et transformation identitaire, quelques résultats prélimin…

2021

Resume But de l’etude Le premier episode psychotique constitue un evenement brutal pour les patients et s’accompagne d’une desorganisation psychique majeure avec une detresse importante. Plusieurs etudes recentes ont ainsi souligne la dimension traumatique du premier episode psychotique chez une large part des patients, et ont montre la prevalence du trouble de stress post-traumatique au sein de cette population. Toutefois, peu d’etudes ont porte leur attention sur cette dimension traumatique sous l’angle du vecu et de l’experience subjective des sujets confrontes au PEP, en dehors des criteres semiologiques du TSPT. Aussi, l’objectif de cette recherche consiste a investiguer de maniere app…

Le défaut de soutien familial dans l’immédiat post-partum : quels impacts sur l’émergence de la détresse maternelle ?

2018

Resume But de l’etude Cette etude vise a evaluer l’impact du defaut de soutien familial dans l’immediat post-partum sur l’etat psychique maternelle et de son evolution 6 mois apres la naissance de l’enfant. Patients et methode Trente-cinq meres primipares, vivant maritalement, ayant beneficie des services d’hospitalisation a domicile (HAD) via leur maternite. Apres leur inclusion, elles ont ete reparties a posteriori en deux groupes, en fonction de la variable independante : soutien familial, obtenue via une utilisation libre du Social Support Questionnaire (SSQ6) de Sarason (1983 ; 1987), rempli par les participantes. La detresse maternelle a ete evaluee sur 4 temps de mesure (T1–2 semaine…

Diagramme mit ggplot2

2020

Mit dem Zusatzpaket ggplot2 lassen sich die in Kap. 14 vorgestellten Diagrammtypen ebenfalls erstellen. Dabei ist die Herangehensweise eine grundsatzlich andere: Wahrend der Basisumfang von R fur verschiedene Diagrammarten einzelne Funktionen bereitstellt, werden mit ggplot2 alle Diagrammtypen mit einem einheitlichen System erzeugt. Sind Diagramme des Basisumfangs analog zu einer Leinwand, auf der jede Funktion spater nicht mehr anderbare Elemente aufmalt, reprasentiert ggplot2 alle Diagrammelemente explizit in einem Objekt. Erstellte Diagramme lassen sich uber dieses Objekt weiter verandern, an Funktionen ubergeben und speichern.

Graph Rewriting Based Search for Molecular Structures: Definitions, Algorithms, Hardness

2018

We define a graph rewriting system that is easily understandable by humans, but rich enough to allow very general queries to molecule databases. It is based on the substitution of a single node in a node- and edge-labeled graph by an arbitrary graph, explicitly assigning new endpoints to the edges incident to the replaced node. For these graph rewriting systems, we are interested in the subgraph-matching problem. We show that the problem is NP-complete, even on graphs that are stars. As a positive result, we give an algorithm which is polynomial if both rules and query graph have bounded degree and bounded cut size. We demonstrate that molecular graphs of practically relevant molecules in d…

Photoexcitation of the P4480 State Induces a Secondary Photocycle That Potentially Desensitizes Channelrhodopsin-2

2018

Channelrhodopsins (ChRs) are light-gated cation channels. In spite of their wide use to activate neurons with light, the photocurrents of ChRs rapidly decay in intensity under both continuous illum...

Evidence of cytotoxic activity against mammalian red blood cell of Na+ channel neurotoxin (Ae1) from sea anemone (Actinia equina)

2016

The diversification of anthozoan toxins played an important role in the ability to colonize various ecological niches. In this study we evaluated the hemolytic activity of HPLC separated fraction of tentacle extracts of sea anemone Actinia equina. Toxic components from acid tissue tentacle extracts were investigated by size exclusion and reverse phase HPLC to characterize cytolytic molecules. A novel low molecular weight active fraction was sequenced by MALDI TOF analysis and a protein correspondent to 5.4 kDa Sodium channel neurotoxin (Ae1) from A. equina was identified. Synthetic Ae1 was assayed and it showed an hemolytic activity against mammalian erythrocytes in a dose dependent manner.…

Synthesis and Cytotoxicity of 1,4-Dihydropyridines and an Unexpected 1,3-Oxazin-6-one

2016

Eight heterocycles have been prepared in a one-pot reaction manner based on the Hantzsch dihydropyridine synthesis. The synthesis afforded seven dihydropyridines (DHP) and one unexpected 1,3-oxazin-6-one. Their structures were confirmed based on NMR spectroscopy and mass spectrometry. The obtained products have been evaluated for their cytotoxicity against eight cancer cell lines and one normal cell line. Two halogenated DHPs (7 and 8) displayed cytotoxicity toward all the nine tested cancer cell lines with IC50 values from 4.10 to 58.90 μm, while others showed selective activities. DHPs (7 and 8) bearing a Me group at C(2) and C(6) as well as a halogenated substituent at C(4′) were more an…

2020

ABSTRACT The vertical structuring of methanotrophic communities and its genetic controllers remain understudied in the water columns of oxygen-stratified lakes. Therefore, we used 16S rRNA gene sequencing to study the vertical stratification patterns of methanotrophs in two boreal lakes, Lake Kuivajärvi and Lake Lovojärvi. Furthermore, metagenomic analyses were performed to assess the genomic characteristics of methanotrophs in Lovojärvi and the previously studied Lake Alinen Mustajärvi. The methanotroph communities were vertically structured along the oxygen gradient. Alphaproteobacterial methanotrophs preferred oxic water layers, while Methylococcales methanotrophs, consisting of putative…

Biological and physical modification of carbonate system parameters along the salinity gradient in shallow hypersaline solar salterns in Trapani, Ita…

2017

Abstract We investigated changes in the chemical characteristics of evaporating seawater under the influence of microbial activity by conducting geochemical analyses of the brines and evaporite sediments collected from solar salterns in Trapani, Italy. The microbial activity had a substantial effect on the carbonate system parameters. Dissolved inorganic carbon (DIC) was substantially removed from the brine during the course of evaporation from the seawater to the point where calcium carbonate precipitates, with an accompanying decrease in its carbon isotopic composition (δ 13 C DIC ) to as low as −10.6‰. Although the removal of DIC was due to calcium carbonate precipitation, photosynthesis…

'Palaeoshellomics' reveals the use of freshwater mother-of-pearl in prehistory

2019

The extensive use of mollusc shell as a versatile raw material is testament to its importance in prehistoric times. The consistent choice of certain species for different purposes, including the making of ornaments, is a direct representation of how humans viewed and exploited their environment. The necessary taxonomic information, however, is often impossible to obtain from objects that are small, heavily worked or degraded. Here we propose a novel biogeochemical approach to track the biological origin of prehistoric mollusc shell. We conducted an in-depth study of archaeological ornaments using microstructural, geochemical and biomolecular analyses, including ‘palaeoshellomics’, the first…