Search results for "Development"
showing 10 items of 26949 documents
3 ′-5 ′ crosstalk contributes to transcriptional bursting
2019
Abstract Background Transcription in mammalian cells is a complex stochastic process involving shuttling of polymerase between genes and phase-separated liquid condensates. It occurs in bursts, which results in vastly different numbers of an mRNA species in isogenic cell populations. Several factors contributing to transcriptional bursting have been identified, usually classified as intrinsic, in other words local to single genes, or extrinsic, relating to the macroscopic state of the cell. However, some possible contributors have not been explored yet. Here, we focus on processes at the 3 ′ and 5 ′ ends of a gene that enable reinitiation of transcription upon termination. Results Using Bay…
The cell nucleus. A study in Burgundy
2019
ABSTRACT Wilhelm Bernhard’s revolutionary microscopy techniques helped him put forward the hypothesis of specialized compartmentalization of the nucleus. He also described for the first time the nuclear bodies and peri-chromatin fibrils, and demonstrated that these granules contain an RNA component. The tradition of biennial workshops, named after this great scientist, continues, and this year it took place in the heart of Burgundy, in Dijon, France (May 20–24, 2019, organized by INSERM UMR1231, UBFC), where well-fed participants emphasized the importance of viewing the cell nucleus as a hub of specialized colloidal compartments that orchestrate replication, transcription and nuclear transp…
Comparative ultrastructure and carbohydrate composition of gastroliths from Astacidae, Cambaridae and Parastacidae freshwater crayfish (Crustacea, De…
2012
21 pages; International audience; Crustaceans have to cyclically replace their rigid exoskeleton in order to grow. Most of them harden this skeleton by a calcification process. Some decapods (land crabs, lobsters and crayfish) elaborate calcium storage structures as a reservoir of calcium ions in their stomach wall, as so-called gastroliths. For a better understanding of the cyclic elaboration of these calcium deposits, we studied the ultrastructure of gastroliths from freshwater crayfish by using a combination of microscopic and physical techniques. Because sugars are also molecules putatively involved in the elaboration process of these biomineralizations, we also determined their carbohy…
Immune Response Failure in Paucisymptomatic Long-Standing SARS-CoV-2 Spreaders
2021
The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread throughout the world. This disease has a spectrum of different clinical pictures with different outcomes. Herein, we report all the data from three paucisymptomatic patients during a hospital stay that might represent a paradigmatic example of the method by which SARS-CoV-2 is shed. We demonstrated the lack of an adequate qualitative and quantitative immune response by multiparametric flow cytometry analysis. Our data can provide a new perspective about the method by which SARS-CoV-2 is shed and the clinical weight of viral persistence. In all three cases, the …
Perceived physical health in family caregivers of Alzheimer patients: Mediator variables
2017
The aim of this work is to know the mediating role of such variables as social support and cope as other associated with Positive Psychology in family caregivers of Alzheimer patients. Method: Participants: 140 caregivers of Alzheimer patients. Instruments: Sociodemographic data; CBI Caregiver Burden Scale; COPE Coping Styles Scale; DUKE.UNC Social Support Scale; QOLLTI-F, Quality of Life in Life Threatening Illness Scale–Family Carers Version; SHS, Subjective Happiness Scale; SWLS, Satisfaction with Life Scale. Results: The most relevant results refer to the partial mediating role of happiness, quality of life and life satisfaction variables between subjective burden and perceived physical…
FETAL GROWTH RESTRICTION: A GROWTH PATTERN WITH FETAL, NEONATAL AND LONG-TERM CONSEQUENCES
2019
Fetal growth restriction (FGR) or intrauterine growth restriction (IUGR) are the terms used for a fetus which has not attained its full growth potential for gestational age. FGR is a multifactorial syndrome responsible for increased fetal and neonatal morbidity and mortality as well as long term adverse outcomes involving auxological, metabolic, organic and functional domains. Clinicians distinguish early and late onset FGR, in relation to specific fetal anthropometric parameters related to the possible primary etiology and to different patterns of placental and maternal cardiovascular pathologies. Delivery of an early onset FGR or growth impaired newborn with congenital pathology should be…
VALUE-BASED EVIDENCES TO FACE THE NEW CHALLENGES OF HEALTH PROMOTION IN A SUSTAINABLE HEALTHCARE SYSTEM.
2017
Thirty years ago, starting from a new awareness of the limits of biomedical power and healthcare services to solve all population’ health problems, the Ottawa Conference coined a New Public Health by defining Health Promotion (HP) as “the process of enabling people to increase control over and to improve their health and well-being”. Since then and over the next 30 years, several programs have been developed all over the world to translate HP concepts into practical actions and many health successes have been achieved as well. Nowadays, even if the global health context has strongly changed, the original principles of HP still provide a solid ground for action, being the community engagemen…
Recycling of almond by-products for intestinal inflammation: improvement of physical-chemical, technological and biological characteristics of a drie…
2020
Background: Almond skins are rich in bioactive compounds that undergo oxidation/degradation phenomena and are poorly soluble in water, reducing in vivo absorption and bioavailability, factors that influence the pharmacological activity of an active product. We developed a dried acetonic almond skins extract/cyclodextrin complex to improve extract solubility, dissolution rate and biological activity. Methods: A lyophilized acetonic almond skin extract was produced. To optimize complex formulation, phase solubility studies and complex characterization (absorption studies, differential scanning calorimetry (DSC), morphology, solubility studies) were performed. To evaluate a possible use in hea…
Social orphanhood in Latvia
2014
The reform processes and the developments of social policy to solve the major social problems of the socially vulnerable population, among them, children in particular, take place in Latvia during the last 20 years. Protection of children rights is declared one of the strategic priorities of the state social policy. At the same time the problem of child neglect and child abandonment in Latvia has not yet been sufficiently conceptualized. Already since 1990-ies Latvian society has clearly faced with an objective necessity of solving problems of child abandonment in connection with an increasing number of social orphans. The situation was complicated by the fact that the formation of a fundam…
Physical activity, nutrition, and bone health
2018
This review aims to describe the roles that physical activity and nutrition have in bone metabolism and to examine their effects on bone in a situation of altered metabolism as a consequence of inadequate nutrition and/or excessive physical activity. Referring to the recent studies and the main guidelines in the literature on athlete nutrition, the paper also focuses on essential nutrients for bone health during performance. Finally, it discusses the negative effect of some nutrients on bone mineral density.