Search results for "Diss"

High Pressure Enhances Hexacoordination in Neuroglobin and Other Globins

2005

The techniques of high applied pressure and flash photolysis have been combined to study ligand rebinding to neuroglobin (Ngb) and tomato Hb, globins that may display a His-Fe-His hexacoordination in the absence of external ligands. High pressure induces a moderate decrease in the His association rate and a large decrease in His dissociation rate, thus leading to an enhancement of the overall His affinity. The overall structural difference between penta- and hexacoordinated globins may be rather small and can be overcome by external modifications such as high pressure. Over the pressure range 0.1-700 MPa (7 kbar), the globins may show a loss of over a factor of 100 in the amplitude of the b…

Mechanistic analysis and experimental verification of bicarbonate-controlled enteric coat dissolution: Potential in vivo implications

2019

Enteric coatings have shown in vivo dissolution rates that are poorly predicted by traditional in vitro tests, with the in vivo dissolution being considerably slower than in vitro. To provide a more mechanistic understanding of this, the dependence of the release properties of various enteric-coated (EC) products on bulk pH and bicarbonate molarity was investigated. It was found that, at presumably in vivo-relevant values, the bicarbonate molarity is a more significant determinant of the dissolution profile than the bulk pH. The findings also indicate that this steep relationship between the dissolution of enteric coatings and bicarbonate molarity limits those coatings' performance in vivo.…

Rapid hyperpolarization and purification of the metabolite fumarate in aqueous solution

2020

Significance Magnetic resonance imaging is hindered by inherently low sensitivity, which limits the method for the most part to observing water molecules in the body. Hyperpolarized molecules exhibit strongly enhanced MRI signals which opens the door for imaging low-concentration species in vivo. Biomolecules can be hyperpolarized and injected into a patient allowing for metabolism to be tracked in real time, greatly expanding the information available to the radiologist. Parahydrogen-induced polarization (PHIP) is a hyperpolarization method renowned for its low cost and accessibility, but is generally limited by low polarization levels, modest molecular concentrations, and contamination by…

Spontaneous fragmentation of multiply charged metal clusters.

1987

Measurement of branching fractions and charge asymmetries for exclusive B decays to charmonium

2005

We report measurements of branching fractions and charge asymmetries of exclusive decays of neutral and charged B mesons into two-body final states containing a charmonium state and a light strange meson. The charmonium mesons considered are J/Psi, Psi(2S) and Chi_c1, and the light meson is either K or K*. We use a sample of about 124 million BBbar events collected with the BABAR detector at the PEP-II storage ring at the Stanford Linear Accelerator Center.

Enhanced Acid Dissociation at the Solid/Liquid Interface

2019

In this chapter we review some recent results from first principles molecular dynamics simulations which show how molecular properties, such as proton dissociation, can be influenced upon adsorption at a solid/liquid interface. In particular, we discuss in details the increased acidity of pyruvic acid at the quartz /water interface, which is of relevance for the chemistry of the atmosphere. Our simulations unveil the special role of the microsolvation at interface, as well as the role of the silanols in stabliziing the deprotonated form of the acid. The enhanced acidity at the hydrophilic quartz/water interface is at odd with what typically found at the water/air interface where acidity is …

Energy-Stable Numerical Schemes for Multiscale Simulations of Polymer–Solvent Mixtures

2017

We present a new second-order energy dissipative numerical scheme to treat macroscopic equations aiming at the modeling of the dynamics of complex polymer–solvent mixtures. These partial differential equations are the Cahn-Hilliard equation for diffuse interface phase fields and the Oldroyd-B equations for the hydrodynamics of the polymeric mixture. A second-order combined finite volume/finite difference method is applied for the spatial discretization. A complementary approach to study the same physical system is realized by simulations of a microscopic model based on a hybrid Lattice Boltzmann/Molecular Dynamics scheme. These latter simulations provide initial conditions for the numerical…

Linfoma no-hodgkin intraoral. presentación de 4 casos clínicos

2001

The non-Hodgkin lymphomas (NHL) represent an heterogeneous group of malignancies of lymphoreticular histogenesis. In most cases, they initially arise within lymph nodes but so-called extranodal lymphomas are also found. The NHL has low incidence in the oral cavity. It may involve bone and/or soft tissues as a primary or secondary manifestation. We present a review of the literature and four clinical cases of intraoral NHL. The first couple of cases are primary forms, the third one is associated to HIV infection and the last one is an oral presentation as a component of more widely disseminated disease.

Structures optiques dissipatives en cavité laser à fibre

2011

This thesis presents a study of the nonlinear dissipative dynamics of localized of self organized structures in passively mode-locked fiber laser through nonlinear polarization evolution. We reveal the existence of a gradual transition from the quasi-cw to mode locked dynamics in the multi-pulsing regime. We emphasize on the intermediate state, where various new dynamics are observed. We study collective behaviors of dissipative solitons in the presence of a continuous background. One of the complex and attractive dynamics presented is the "soliton rain", which composed of three field components : continuous modes of background, drifting of solitons and condensed phase solitons. This dynami…

Global charcoal mobilization from soils via dissolution and riverine transport to the oceans

2013

Dissolving Charcoal Biomass burning produces 40 to 250 million tons of charcoal per year worldwide. Much of this is preserved in soils and sediments for thousands of years. However, the estimated production rate of charcoal is significantly larger than that of decomposition, and Jaffe et al. (p. 345 ; see the Perspective by Masiello and Louchouarn ) calculate that a large fraction of the charcoal produced by fires is lost from the land through dissolution and transport to the oceans.