Search results for "Dosage"
showing 10 items of 516 documents
Amorphous Ropinirole-Loaded Mucoadhesive Buccal Film: A Potential Patient-Friendly Tool to Improve Drug Pharmacokinetic Profile and Effectiveness
2020
Nowadays the therapeutic strategies to manage Parkinson&rsquo
A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts
2020
Polymerase chain reaction (PCR) detection has become the gold standard for diagnosis and typing of enterovirus (EV) and human parechovirus (HPeV) infections. Its effectiveness depends critically on using the appropriate sample types and high assay sensitivity as viral loads in cerebrospinal fluid samples from meningitis and sepsis clinical presentation can be extremely low. This study evaluated the sensitivity and specificity of currently used commercial and in‐house diagnostic and typing assays. Accurately quantified RNA transcript controls were distributed to 27 diagnostic and 12 reference laboratories in 17 European countries for blinded testing. Transcripts represented the four human EV…
Some effects of a buried electricity transmission cable on bulk soil.
2007
A case study in NW Italy investigating an underground electric line (1 m depth triple cable at operative voltages 220-380 kV) measured electric fields in the surrounding soil virtually close to zero but magnetic fields (microTs) 20 times the background level. After 6 months, the influence radius around the cable on microbial activity (estimated by soil ATP), organic carbon, and total nitrogen follows exactly the inverse trend of the MF, shifting the biological activity with a lag distance of 5 m from the 220 kV cable.
Quality control for exposure assessment in epidemiological studies
2010
In the framework of an epidemiological study, dosemeters were used for the assessment of radio frequency electromagnetic field exposure. To check the correct dosemeter's performance in terms of consistency of recorded field values over the entire study period, a quality control strategy was developed. In this paper, the concept of quality control and its results is described. From the 20 dosemeters used, 19 were very stable and reproducible, with deviations of a maximum of +/- 1 dB compared with their initial state. One device was found to be faulty and its measurement data had to be excluded from the analysis. As a result of continuous quality control procedures, the confidence in the meas…
Isolated bladder exstrophy associated with a de novo 0.9 Mb microduplication on chromosome 19p13.12
2012
BACKGROUND: The exstrophy-epispadias complex (BEEC) is a urogenital birth defect of varying severity. The causes of the BEEC are likely to be heterogeneous, with individual environmental or genetic risk factors still being largely unknown. In this study, we aimed to identify de novo causative copy number variations (CNVs) that contribute to the BEEC. METHODS: Array-based molecular karyotyping was performed to screen 110 individuals with BEEC. Promising CNVs were tested for de novo occurrence by investigating parental DNAs. Genes located in regions of rearrangements were prioritized through expression analysis in mice to be sequenced in the complete cohort, to identify high-penetrance mutati…
FUZZY RISK ANALYSIS OF A MODERN γ-RAY INDUSTRIAL IRRADIATOR
2011
Fuzzy fault tree analyses were used to investigate accident scenarios that involve radiological exposure to operators working in industrial γ-ray irradiation facilities. The HEART method, a first generation human reliability analysis method, was used to evaluate the probability of adverse human error in these analyses. This technique was modified on the basis of fuzzy set theory to more directly take into account the uncertainties in the error-promoting factors on which the methodology is based. Moreover, with regard to some identified accident scenarios, fuzzy radiological exposure risk, expressed in terms of potential annual death, was evaluated. The calculated fuzzy risks for the examine…
Correction: DAPIT Over-Expression Modulates Glucose Metabolism and Cell Behaviour in HEK293T Cells
2015
Introduction Diabetes Associated Protein in Insulin-sensitive Tissues (DAPIT) is a subunit of mitochondrial ATP synthase and has also been found to associate with the vacuolar H+-ATPase. Its expression is particularly high in cells with elevated aerobic metabolism and in epithelial cells that actively transport nutrients and ions. Deletion of DAPIT is known to induce loss of mitochondrial ATP synthase but the effects of its over-expression are obscure. Results In order to study the consequences of high expression of DAPIT, we constructed a transgenic cell line that constitutively expressed DAPIT in human embryonal kidney cells, HEK293T. Enhanced DAPIT expression decreased mtDNA content and …
Swellable microparticles containing Suprofen: evaluation of in vitro release and photochemical behaviour
1998
Suprofen, an anti-inflammatory drug was incorporated in polymer networks based on biocompatible macromolecules, such as alpha,beta-polyasparthydrazide (PAHy) and alpha,beta-poly(N-hydroxyethyl)-DL-aspartamide (PHEA) crosslinked by glutaraldehyde or gamma-rays, respectively. Swelling tests carried out in aqueous media showed that pH value affects the swelling degree of the prepared hydrogels. In vitro release tests were performed in simulated gastrointestinal fluids (pH 1/6.8) using the pH variation method and in phosphate-buffered saline, pH 7.4. Experimental data indicated that Suprofen was released in a sustained way both from PAHy and PHEA microparticles. Further, incorporation of Suprof…
Fluorimetric determination of captopril by flow injection analysis
1991
A flow injection analysis procedure is proposed for the determination of captopril. The sample solution was directly injected into the carrier-reagent stream which was prepared by a solution of ceric ions in 0.25 M sulfuric acid. The procedure is based on the fluorimetric monitoring of the formed Ce(III). Chemical, FIA, and instrumental parameters were optimized and the procedure is applied to the captopril determination in pharmaceutical formulations with competitive precision and adequate accuracy.
FIA-fluorimetric determination of adrenaline by oxidation with a solid-phase reactor of manganese dioxide incorporated in polyester resin beads
1995
Abstract The FIA-spectrofluorimetric determination of adrenaline was carried out by reaction of the drug with manganese dioxide entrapped in a polymeric material in a solid-phase reactor; the oxidized drug was monitored fluorimetrically at 540 nm (Ioxg. 330.0 nm). The calibration graph for adrenaline was linear over the range 0.5 - 20 μg ml−1 with a relative standard deviation of 2.0% (at 5 ug ml−1) and the sample throughput of 65 h−1. The influence of foreign compounds was studied and the method was applied to the determination of adrenaline content in a pharmaceutical formulation . ∗Present address: Institut of Chemistry, Warsawa University, Bialystok Branch, Bialystok, Poland.