Search results for "EMBER"
showing 10 items of 549 documents
Mind the Gap: The Big House in Cinematic Representations of the Anglo-Irish War
2018
It goes without saying that the Big House was intended to be a symbol: as more than one critic has remarked, these houses really were only “big” in comparison to the poverty of the lesser structures that surrounded them. They were to be a bastion for British and Anglo-Irish culture and a center for social and administrative interactions. In this sense, they straddled the gap between the towns of Dublin and London, whence their power came, and the villages to whom they administered: it is no coincidence that these garrisons of British power bore the brunt of Republican anger during the Troubles of 1919-1921. Examining two of the rare films to focus on the War of Independence from the perspec…
Cytotoxicity of the bisphenolic honokiol from Magnolia officinalis against multiple drug-resistant tumor cells as determined by pharmacogenomics and …
2014
A main problem in oncology is the development of drug-resistance. Some plant-derived lignans are established in cancer therapy, e.g. the semisynthetic epipodophyllotoxins etoposide and teniposide. Their activity is, unfortunately, hampered by the ATP-binding cassette (ABC) efflux transporter, P-glycoprotein. Here, we investigated the bisphenolic honokiol derived from Magnolia officinalis. P-glycoprotein-overexpressing CEM/ADR5000 cells were not cross-resistant to honokiol, but MDA-MB-231 BRCP cells transfected with another ABC-transporter, BCRP, revealed 3-fold resistance. Further drug resistance mechanisms analyzed study was the tumor suppressor TP53 and the epidermal growth factor recepto…
The Long Route Towards a Widespread European Culture of Alternatives to Immigration Detention
2016
The aim of this article is to provide an analysis of the application by some European Union countries of alternative measures to detention of migrants. Sections 2 and 3 indicate, in line with European normatives and with detention being a measure of last resort, that Member States having ascertained that there are grounds for the detention of migrants, should evaluate whether the aims pursued can be achieved through a less coercive measure which respects the fundamental rights of individuals. Unfortunately, as examined in Section 4, analysis of most European countries’ law reveals an unsatisfactory application of alternative measures to detention. As in, for example, Italy’s case, whose leg…
The need for harmonizing methodologies for assessing soil threats in Europe
2010
Central to the EU thematic strategy for soil protection is that areas affected by soil degradation through erosion, soil organic matter (SOM) decline, compaction, salinization and landslides should be identified in a clear and consistent way. However, the current methodologies to achieve this often differ and this can result in different perceptions of risks amongst EU Member States. The aims of this paper are to: (i) assess the current status of assessment methodologies in Europe (EU27) associated with erosion, SOM decline, compaction, salinization and landslides and (ii) discuss the issues associated with harmonization of these methodologies throughout the EU27. The need for harmonization…
Kawalerzysta, dowódca i wykładowca - szkic do biografii gen. bryg. Konstantego Druckiego-Lubeckiego (1893-1940)
2018
Celem przeprowadzonych badań było opracowanie rozszerzonego szkicu biograficznego księcia gen. bryg. Konstantego Druckiego-Lubeckiego. Dzięki zebranym dokumentom i materiałom ustalono najważniejsze fakty z życia generała, dotyczące jego pochodzenia, nauki w Cesarskim Aleksandrowskim Liceum (Lycee Imperial Alexandre) w Petersburgu, udziału w walkach o niepodległość Polski oraz kariery w kawalerii i szkolnictwie wojskowym II RP. Udostępnione przez bliskich księcia materiały, skonfrontowane ze źródłami urzędowymi i dostępnymi publikacjami, pozwoliły także na ustalenie dodatkowych okoliczności związanych z jego śmiercią z rąk NKWD w 1940 roku. Dokumenty te umożliwiły rekonstrukcję podejmowanych…
Identification and validation of quasispecies models for biological systems
2009
An identification procedure for biological systems cast as quasi-species models is proposed. Their identification is a challenging problem because of the bilinear dependence on the parameters and their physical constraints. The proposed solution is within the framework of set-membership identification. %The bilinear dependence on parameters of the model and their physical constraints make the present issue challenging. We determine an estimate of the model parameters together with their interval of variability (Uncertainty Intervals), taking into account all the physical constraints. Invalidation/validation is performed on the basis of the predictive capability of the estimated models. The …
TAP-polymorphisms in juvenile onset psoriasis and psoriatic arthritis.
1996
Abstract Juvenile onset psoriasis is strongly associated with the HLA-class I genes Cw6 and B57 whereas patients with psoriatic arthritis show an increased frequency of HLA-B27. It is unclear whether additional major histocompatibility genes also increase disease susceptibility. The TAP genes (transporter associated with antigen processing) encode two membrane-spanning proteins that translocate antigenic peptides from the cytoplasm into the endoplasmic reticulum. Comparison of 60 patients with juvenile onset psoriasis, 63 psoriatic arthritis patients, and 101 caucasoid controls revealed an increase of the TAP1 ∗ 0101 allele in the psoriasis group, that could not be explained by linkage to o…
Differentiation of Effector/Memory Vδ2 T Cells and Migratory Routes in Lymph Nodes or Inflammatory Sites
2003
Vδ2 T lymphocytes recognize nonpeptidic antigens without presentation by MHC molecules and mount both immediate effector functions and memory responses after microbial infection. However, how Vδ2 T cells mediate different facets of a memory response remains unknown. Here, we show that the expression of CD45RA and CD27 antigens defines four subsets of human Vδ2 T cells with distinctive compartmentalization routes. Naive CD45RA+CD27+ and memory CD45RA−CD27+ cells express lymph node homing receptors, abound in lymph nodes, and lack immediate effector functions. Conversely, memory CD45RA−CD27− and terminally differentiated CD45RA+CD27− cells, which express receptors for homing to inflamed tissu…
In situ kinetic modelling of intestinal efflux in rats: functional characterization of segmental differences and correlation with in vitro results.
2007
The objective was to devise and apply a novel modelling approach to combine segmental in situ rat perfusion data and in vitro cell culture data, in order to elucidate the contribution of efflux in drug absorption kinetics. The fluoroquinolone CNV97100 was used as a model P-gp substrate. In situ intestinal perfusion was performed in rat duodenum, jejunum, ileum and colon to measure the influence of P-gp expression on efflux. Inhibition studies of CNV97100 were performed in the presence of verapamil, quinidine, cyclosporin A and p-aminohippuric acid. Absorption/efflux parameters were modelled simultaneously, using data from both in situ studies as well as in vitro studies. The maximal efflux …
Profile of P-glycoprotein distribution in the rat and its possible influence on the salbutamol intestinal absorption process.
2004
8 pages, 2 figures, 2 tables.--PMID: 15124220 [PubMed]