Search results for "ER stre"

SCI Brief Form (SCI-BF): Psychometric and Factor Structure Analyses in Argentina

2018

Resumen El estudio de las virtudes y fortalezas del carácter es uno de los temas más importantes dentro de la psicología positiva. Peterson y Seligman (2004) determinaron que 24 fortalezas del carácter estaban vinculadas a 6 virtudes y llamaron VIA a esa clasificación. Nuestro trabajo está incluido en la investigación sobre esa clasificación. Se desarrolló un instrumento de medición de 24 ítems de autopuntuación global directa para evaluar las 24 fortalezas del carácter de la clasificación de Peterson y Seligman (2004). Este instrumento es la versión corta del IVyF. Se analizaron las características psicométricas de este instrumento llamado IVyF abreviado (IVyFabre; Strength of Character In…

Exogenous Growth Regulators and Water Stress Enhance Long-Term Storage Quality Characteristics of Onion

2023

Exogenous growth regulators (GRs) play a crucial role in alleviating water stress and sustaining crop yields in water-stressed areas. However, their effects on onions post-harvest quality, particularly post-monsoon onion—often preferred for long-term storage—were never studied. Therefore, this led us to investigate the interaction between water stress and GRs on the physiochemical and functional quality attributes of onions during long-term storage (9 months, at 25 ± 1 °C and 65 ± 5% RH). Onion crop was raised under four water stress levels i.e., 1.00–0.85, 0.84–0.70, 0.69–0.40, and 0.39–0.10 IW: CPE, designated as no, low, medium, and s…

Effects of 5-Azacitidine on Dnmt2/Trdmt1 expression levels and endoplasmic reticulum stress in cellular models of insulinoma

2021

Diabetes mellitus affects people all over the world of all ages or social groups making it a worldwide healthcare challenge. Moreover, untreated or badly treated diabetes carries a risk of serious complications including premature death (IDF Diabetes Atlas 9th edition, 2019). The main symptom of diabetes is insulin secretion and/or action disorder leading to hyperglycemia what results in impaired carbohydrate, fat, and protein metabolism (“Diagnosis and Classification of Diabetes Mellitus,” 2013). Dnmt2/ Trdmt1 in its structure and sequence is similar to DNA methyltransferases, however, it has been shown that mainly methylates aspartic acid transfer RNA, specifically at the cytosine-38 resi…

Relationship Between Oxidative Stress, ER Stress, and Inflammation in Type 2 Diabetes: The Battle Continues

2019

Type 2 diabetes (T2D) is a metabolic disorder characterized by hyperglycemia and insulin resistance in which oxidative stress is thought to be a primary cause. Considering that mitochondria are the main source of ROS, we have set out to provide a general overview on how oxidative stress is generated and related to T2D. Enhanced generation of reactive oxygen species (ROS) and oxidative stress occurs in mitochondria as a consequence of an overload of glucose and oxidative phosphorylation. Endoplasmic reticulum (ER) stress plays an important role in oxidative stress, as it is also a source of ROS. The tight interconnection between both organelles through mitochondrial-associated membranes (MAM…

Isometric force-time parameters in monitoring of strength training : with special reference to acute responses to different loading resistances

2017

The aim of the present series of studies was to investigate acute neuromuscular responses to (1) different strength training loadings and using (2) different external resistances. In addition, chronic adaptations and dynamic performances were compared to (3) the changes in isometric force-time parameters at the group level, and to (4) the individual timing of the improvement in the rate of force development (RFD) due to hypertrophic or maximum strength followed by power strength training periods. The latter one was achieved by systematic, repeated monitoring. Sixty-nine physically active men (20-35 yrs), but not experienced in resistance training, took part in the present series of studies.…

Ruolo citotossico del cannabinoide sintetico WIN55,212-2 in cellule di osteosarcoma MG63: coinvolgimento della proteina SPARC.

Il cannabinoide sintetico WIN 55,212-2 è un potente agonista sintetico del recettore per i cannabinoidi con spiccate potenzialità antitumorali. Gli esperimenti riportati in questa tesi sono stati condotti per delineare gli effetti indotti dal WIN sulla proliferazione, la migrazione e la sensibilizzazione alla morte indotta dalla citochina TRAIL in cellule di osteosarcoma umano MG63. I risultati ottenuti mostrano che il WIN induce un blocco del ciclo cellulare in fase G2/M che è associato all’induzione dei principali markers di ER stress (GRP78, CHOP e TRB3). Nelle cellule trattate abbiamo inoltre osservato la conversione della forma citosolica del marker autofagosomale LC3-I in LC3-II (la f…

Impact of Aortic Stenosis on Myofiber Stress: Translational Application of Left Ventricle-Aortic Coupling Simulation

2020

The severity of aortic stenosis (AS) has traditionally been graded by measuring hemodynamic parameters of transvalvular pressure gradient, ejection jet velocity, or estimating valve orifice area. Recent research has highlighted limitations of these criteria at effectively grading AS in presence of left ventricle (LV) dysfunction. We hypothesized that simulations coupling the aorta and LV could provide meaningful insight into myocardial biomechanical derangements that accompany AS. A realistic finite element model of the human heart with a coupled lumped-parameter circulatory system was used to simulate AS. Finite element analysis was performed with Abaqus FEA. An anisotropic hyperelastic mo…

Ecophysiological and molecular processes involved in water stress memory in pea: from gene expression regulation to plant hydromineral nutrition

2022

Climate change induces increasingly frequent periods of water deficits during the crop cycle. These periods of water stress negatively impact the plant, notably by limiting the availability of resources (water, mineral elements) and by limiting carbon fixation by the plant. In this context, several studies highlighted the beneficial effect of “priming” of a first stress on the response to a second stress by the induction of a transcriptional memory. This memory depends on epigenetic modifications implemented during the first stress. These modifications can regulate the expression of genes known as “memory genes” which have been characterized in the aerial parts of Arabidospsis and maize. Ho…

Relations between teacher-child interactions and children's learning and motivation in Finnish kindergartens

2012

Physiological and Structural Responses to Prolonged Water Deficit in Young Trees of Two Olive Cultivars

2022

This study aimed to characterize the physiological and structural responses of potted one-year-old olive trees belonging to two olive cultivars—‘Nocellara del Belice’ and ‘Cerasuola’—exposed to prolonged drought under greenhouse conditions. Two irrigation treatments based on evapotranspiration (ET) were imposed for 69 days, i.e., well-watered (WW, 100% ET) and drought-stressed (DS, 10–30% ET). Leaf stomatal conductance (gs), stem water potential (Ψstem), transpiration (E), photosynthetic capacity (Amax), water use efficiency (WUE), stem (Kstem) and root (Kroot) hydraulic conductance, trunk diameter variations (TDV), and leaf patch attenuated pre…