Search results for "FATE"

Dextran sulfate sodium leads to chronic colitis and pathological angiogenesis in Endoglin heterozygous mice

2010

Pathological angiogenesis is an intrinsic component of chronic intestinal inflammation, which results in remodeling and expansion of the gut microvascular bed. Endoglin is essential for endothelial cell function and physiological angiogenesis. In this study we investigated its potential role in the regulation of inflammation by testing the response of Endoglin heterozygous (Eng(+/-)) mice to experimental colitis.C57BL/6 Eng(+/-) and littermate control mice drank water supplemented with 3% dextran sulfate sodium (DSS) for 5 days and were monitored for up to 26 days for clinical signs of colitis. Inflammation, crypt damage, and angiogenic index were scored on histological sections of distal c…

2013

Cortical function is impaired in various disorders of the central nervous system including Alzheimer’s disease, autism and schizophrenia. Some of these disorders are speculated to be associated with insults in early brain development. Pericytes have been shown to regulate neurovascular integrity in development, health and disease. Hence, precisely controlled mechanisms must have evolved in evolution to operate pericyte proliferation, repair and cell fate within the neurovascular unit (NVU). It is well established that pericyte deficiency leads to NVU injury resulting in cognitive decline and neuroinflammation in cortical layers. However, little is known about the role of pericytes in pathop…

Extracellular space and electrolyte distribution in cortex and white matter of dog brain in cold induced oedema

1973

24 hours after a circumscribed cold injury of the cortex dog brains were perfused from the lateral ventricle and the frontal subarachnoidal space to the cisterna magna with an artificial CSF containing trace amounts of35S-labelled thiosulphate. Simultaneously the extracellular tracer was administered intravenously. Extracellular fluid volume was estimated and found to be increased from 10 to 15% in the oedematous cortex and from 10 to 27% in the oedematous white matter. The actual size of ECS in oedematous white matter, however, must be larger as indicated by the relative alterations of thiosulphate distribution, tissue water, sodium and chloride. Apparently a small part of the fluid accumu…

A statistical study of the quality of surface water intended for human consumption near Valencia (Spain)

2007

Water quality in the European Union is subject to legislation through directives that are applicable in all Member States. The directives specify a set of physical and chemical parameters that should be regularly controlled using a network of sampling points, with sampling based on the intended use of the water. This paper presents the results of a statistical comparison of the quality of water intended for human consumption at two different locations (the Canal de Benagéber and the Canal Júcar-Turia) near the town of Valencia (Spain). These are currently the only canals that could supply Valencia and other nearby towns with drinking water. The parameters considered in this paper are the on…

Modelling anaerobic biomass growth kinetics with a substrate threshold concentration.

2004

Abstract Many bacteria have been observed to stop growing below a certain substrate threshold concentration. In this study, a modification of the Monod kinetics expression has been proposed to take into account this substrate threshold concentration observed in bacterial growth. Besides the threshold concentration no additional parameters have been added to the kinetic expression and so, only the substrate threshold concentration and the half-saturation constant have to be estimated for model calibration purposes. Furthermore, for parameter estimation purposes, practical identifiability of this new function has been studied and the results have been satisfactory. The new model has been appl…

Urinaryp-cresol is elevated in young French children with autism spectrum disorder: a replication study

2014

The aromatic compound p-cresol (4-methylphenol) has been found elevated in the urines of Italian autistic children up to 8 years of age. The present study aims at replicating these initial findings in an ethnically distinct sample and at extending them by measuring also the three components of urinary p-cresol, namely p-cresylsulfate, p-cresylglucuronate and free p-cresol. Total urinary p-cresol, p-cresylsulfate and p-cresylglucuronate were significantly elevated in 33 French autism spectrum disorder (ASD) cases compared with 33 sex- and age-matched controls (p < 0.05). This increase was limited to ASD children aged ≤8 years (p < 0.01), and not older (p = 0.17). Urinary levels of p-cresol a…

�ber das Verhalten und Reaktionsverm�gen von glatter Muskulatur und Herzmuskulatur in chloridfreiem Medium (Methylsulfat-Tyrode-L�sung)

1961

Um die Bedeutung der Chlorid-Ionen fur die Funktion von glatter Muskulatur und Herzgewebe zu untersuchen, wurden die Chlorid-Ionen der Tyrodelosung durch die einwertigen, nicht permeierenden und indifferenten Methylsulfat-Ionen ersetzt. Die Versuche wurden am Meerschweinchen-Ileum, Kaninchen-Duodenum, Ratten-Uterus, spontan schlagenden Vorhof des Meerschweinchens und am Froschherz nach Straub durchgefuhrt. Keines der genannten Organe reagierte beim Uberfuhren in chloridfreies Medium oder bei stundenlangem Aufenthalt in Methylsulfat-Tyrodelosung mit einer wesentlichen Funktionsanderung. Wahrend die Herzmuskulatur in chloridfreiem Milieu unverandert auf positiv oder negativ inotrop wirksame S…

Purification of a nuclease from human serum.

1981

The purification procedure for a nuclease from human serum is described. It includes ammonium sulfate precipitation, chromatography on DEAE-Sephadex and on Sephacryl-S 200, and preparative electrophoresis. The enzyme, purified about 2000-fold, is homogeneous in a sodium dodecyl sulfate electrophoretic system, where it has a mol. wt of 78,000. The pH optimum lies around pH 6.5; it is a sugar-nonspecific endonuclease.

Dielectric barrier discharge at the triglycine sulfate crystal surface: the role of the electric field of the domain structure

2014

Dielectric barrier discharges (DBD) at the triglycine sulfate crystal surface, generated in air under controlled gas pressure, have been investigated. Electrical characterization of these DBD discharges, produced at temperatures below as well as above the ferroelectric phase transition, are presented. The influence of the electric field of the domain structure on these DBD discharges are discussed in the frame of a model which takes into account the dynamics of the domain structure of the ferroelectric barrier under the action of an external voltage.

Distribution of rare earth elements in marine sediments from the Strait of Sicily (western Mediterranean Sea): Evidence of phosphogypsum waste contam…

2010

Concentrations of rare earth elements (REE), Y, Th and Sc were recently determined in marine sediments collected using a box corer along two onshore–offshore transects located in the Strait of Sicily (Mediterranean Sea). The REE + Y were enriched in offshore fine-grained sediments where clay minerals are abundant, whereas the REE + Y contents were lower in onshore coarse-grained sediments with high carbonate fractions. Considering this distribution trend, the onshore sediments in front of the southwestern Sicilian coast represent an anomaly with high REE + Y concentrations (mean value 163.4 lg g 1) associated to high Th concentrations (mean value 7.9 lg g 1). Plot of shale-normalized REE + …