Search results for "FATIGUE"
showing 10 items of 651 documents
A Model for High-Cycle Fatigue in Polycrystals
2018
A grain-scale formulation for high-cycle fatigue inter-granular degradation in polycrystalline aggregates is presented. The aggregate is represented through Voronoi tessellations and the mechanics of individual bulk grains is modelled using a boundary integral formulation. The inter-granular interfaces degrade under the action of cyclic tractions and they are represented using cohesive laws embodying a local irreversible damage parameter that evolves according to high-cycle continuum damage laws. The consistence between cyclic and static damage, which plays an important role in the redistribution of inter-granular tractions upon cyclic degradation, is assessed at each fatigue solution jump,…
A Model for Low-Cycle Fatigue in Micro-Structured Materials
2019
A microscale formulation for low-cycle fatigue degradation in heterogeneous materials is presented. The interface traction-separation law is modelled by a cohesive zone model for low-cycle fatigue analysis, which is developed in a consistent thermodynamic framework of elastic-plastic-damage mechanics with internal variables. A specific fatigue activation condition allows to model the material degradation related to the elastic-plastic cyclic loading conditions, with tractions levels lower than the static failure condition. A moving endurance surface, in the classic framework of kinematic hardening, enables a pure elastic behaviour without any fatigue degradation for low levels of cyclic tra…
A Thermodynamically Consistent CZM for Low-Cycle Fatigue Analysis
2018
A cohesive zone model for low-cycle fatigue analysis is developed in a consistent thermodynamic framework of elastic-plastic-damage mechanics with internal variable. A specific fatigue activation condition allows to model the material degradation related to the elastic-plastic cyclic loading conditions, with tractions levels lower than the damage activation condition. A moving endurance surface, in the classic framework of kinematic hardening, enables a pure elastic behavior without any fatigue degradation for low levels loading conditions.
A preliminary investigation about the observation of regional skin temperatures following cumulative training loads in triathletes during training ca…
2019
There are controversial results in the literature concerning the concept that cumulative training load could affect basal skin temperature in the days following training sessions. The objective was to measure skin temperature in triathletes during a training camp with cumulative training load. Ten male recreational triathletes involved in a training camp underwent measurements of perception of pain and fatigue (visual analogue scale), skin temperature (infrared thermography), and jump performance (counter movement jump test) before, one day, and two days after the beginning of the training camp. All measurements were performed before the breakfast. Jump height did not differ between the day…
Improving surface integrity of additively manufactured GP1 stainless steel by roller burnishing
2020
Abstract Additive manufacturing can rapidly fabricate the desired components by selectively melting and solidifying feedstock, rather than conventional subtractive machining. However, the difference between the two routes in terms of surface integrity of the final component is relevant. This paper presents a strategy to control the surface characteristics of additively manufactured stainless steel by roller burnishing. In particular, process parameters have been carefully selected to improve the surface integrity of the worked material. The quality of the surface has been analyzed in terms of roughness, hardness, microstructure and residual stresses. The overall product endurance under high…
On the estimation of the fatigue cycle distribution from spectral density data
1999
This paper deals with the fatigue life prediction of components and structures subjected to random fatigue, i.e. to cyclic loading whose amplitude varies in an essentially random manner. In particular, this study concentrates on the general problem of directly relating fatigue cycle distribution to the power spectral density (PSD) by means of closed-form expressions that avoid expensive digital simulations of the stress process. At present, all the methods proposed to achieve this objective are based on the use of a single parameter of the PSD. In this work, by numerical simulations and theoretical considerations, it is shown that the statistical distribution of fatigue cycles depends on f…
Chronic, but not acute, fatigue predicts self-reported attentional driving errors in mothers attending infant children
2019
AbstractMothers attending infant children usually experience high levels of fatigue, and fatigue has been shown to be related to car crashes through attentional errors, among other causes. The current study investigates the effects of fatigue on the attentional errors while driving of women attending infant children. A sample of 112 women—67 attending infant children and 45 not attending—filled out self-report questionnaires assessing acute fatigue, chronic fatigue, and attention-related driving errors. A mediational analysis showed that women attending infant children had higher levels of fatigue, and that chronic fatigue, but not acute fatigue, was related to attentional errors while driv…
Intra-neuronal Competition for Synaptic Partners Conserves the Amount of Dendritic Building Material
2017
Brain development requires correct targeting of multiple thousand synaptic terminals onto staggeringly complex dendritic arbors. The mechanisms by which input synapse numbers are matched to dendrite size, and by which synaptic inputs from different transmitter systems are correctly partitioned onto a postsynaptic arbor, are incompletely understood. By combining quantitative neuroanatomy with targeted genetic manipulation of synaptic input to an identified Drosophila neuron, we show that synaptic inputs of two different transmitter classes locally direct dendrite growth in a competitive manner. During development, the relative amounts of GABAergic and cholinergic synaptic drive shift dendrit…
Phase 2 study of the bispecific T-cell engager (BiTE) antibody blinatumomab in relapsed/refractory diffuse large B-cell lymphoma.
2015
Few patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) achieve prolonged disease-free survival. Blinatumomab, a bispecific T-cell engaging antibody construct, transiently links CD3-positive T cells to CD19-positive B cells. This phase 2 study evaluated stepwise (9-28-112 μg/d with weekly dose increases; n = 23) or flat (112 μg/d; n = 2) dosing of blinatumomab by continuous infusion, with dexamethasone prophylaxis, in patients with relapsed/refractory DLBCL. Patients received a median of 3 prior lines of therapy. Median time since last regimen was 1.5 months. Seventeen patients ended treatment in cycle 1 (induction), 7 in cycle 2 (consolidation), and 1 in retreatment. Am…
Safety and effectiveness of regorafenib in patients with metastatic colorectal cancer in routine clinical practice in the prospective, observational …
2019
Abstract Background Regorafenib prolonged overall survival (OS) versus placebo in patients with treatment-refractory metastatic colorectal cancer (mCRC) in phase III trials. We conducted an observational study of regorafenib for patients with mCRC in real-world clinical practice. Methods The international, prospective, CORRELATE study recruited patients with mCRC previously treated with approved therapies, for whom the decision to treat with regorafenib was made by the treating physician according to the local health authority approved label. The primary objective was safety, assessed by treatment-emergent adverse events (TEAEs; National Cancer Institute Common Terminology Criteria for Adve…