Search results for "FLIP"

Enseñar Sociología a quienes no estudian Sociología

2019

[EN] The sociological imagination (Wright Mills, 1993) is fundamental in the teaching profession. It is not possible to understand individuals’ actions of the different education agents without knowing their place in the social structure. The objective of this proposal is that the students of the Degree in Preschool Education (University of Valencia) achieve this point of view. The project starts with a flipped classroom methodology in combination with other active methodologies to end contrasting scientific knowledge with the daily teacher’s work, through the realization and analyses of interviews.

Respuesta docente frente a la pandemia de la COVID-19: el uso de Blackboard y Flipped Teaching en la asignatura de Metodología Arqueológica

2020

[ES] El sistema educativo universitario se basa en gran medida en clases presenciales. Un evento inesperado como la pandemia de la COVID-19, que estalló durante los primeros meses del 2020, llevó a las autoridades a declarar el estado de alerta y a tomar, entre otras medidas, la interrupción de la actividad docente presencial. El profesorado universitario tuvo que adaptar la actividad docente a un sistema, para muchos, novedoso: la docencia en línea. Este trabajo tiene como objetivo mostrar los instrumentos y las estrategias empleadas para dar una rápida respuesta a una situación de emergencia. Nuestro caso se centra en la enseñanza de una asignatura de tercer curso del Grado de Historia en…

Structure and Electronic Properties of an Expanded Terpyridine Complex of Nickel(II) [Ni(ddpd)2](BF4)2

2018

A Vanadium(III) Complex with Blue and NIR-II Spin-Flip Luminescence in Solution.

2020

Luminescence from Earth-abundant metal ions in solution at room temperature is a very challenging objective due to the intrinsically weak ligand field splitting of first-row transition metal ions, which leads to efficient nonradiative deactivation via metal-centered states. Only a handful of 3d

INSEGNANTI CAPOVOLTI. LA METODOLOGIA DEL FLIPPED TEACHING NELLA CLASSE DI LINGUA

Chemotherapy overcomes TRAIL-R4-mediated TRAIL resistance at the DISC level

2011

International audience; TNF-related apoptosis-inducing ligand or Apo2L (Apo2L/TRAIL) is a promising anti-cancer drug owing to its ability to trigger apoptosis by binding to TRAIL-R1 or TRAIL-R2, two membrane-bound receptors that are often expressed by tumor cells. TRAIL can also bind non-functional receptors such as TRAIL-R4, but controversies still exist regarding their potential to inhibit TRAIL-induced apoptosis. We show here that TRAIL-R4, expressed either endogenously or ectopically, inhibits TRAIL-induced apoptosis. Interestingly, the combination of chemotherapeutic drugs with TRAIL restores tumor cell sensitivity to apoptosis in TRAIL-R4-expressing cells. This sensitization, which ma…

Regulating TRAIL Receptor-Induced Cell Death at the Membrane: A Deadly Discussion

2011

Article Open access plus; International audience; The use of TRAIL/APO2L and monoclonal antibodies targeting TRAIL receptors for cancer therapy holds great promise, due to their ability to restore cancer cell sensitivity to apoptosis in association with conventional chemotherapeutic drugs in a large variety of tumors. TRAIL-induced cell death is tightly regulated right from the membrane and at the DISC (Death-Inducing Signaling Complex) level. The following patent and literature review aims to present and highlight recent findings of the deadly discussion that determines tumor cell fate upon TRAIL engagement.

IL-4 protects tumor cells from anti-CD95 and chemotherapeutic agents via up-regulation of antiapoptotic proteins

2004

Abstract We recently proposed that Th1 and Th2 cytokines exert opposite effects on the pathogenesis and clinical outcome of organ-specific autoimmunity by altering the expression of genes involved in target cell survival. Because a Th2 response against tumors is associated with poor prognosis, we investigated the ability of IL-4 to protect tumor cells from death receptor- and chemotherapy-induced apoptosis. We found that IL-4 treatment significantly reduced CD95 (Fas/APO-1)- and chemotherapeutic drug-induced apoptosis in prostate, breast, and bladder tumor cell lines. Analysis of antiapoptotic protein expression revealed that IL-4 stimulation resulted in up-regulation of cellular (c) FLIP/F…

Liver methylene fraction by dual- and triple-echo gradient-echo imaging at 3.0T: Correlation with proton MR spectroscopy and estimation of robustness…

2011

Purpose To assess the systematic errors in liver methylene fraction (LMF) resulting from fat–fat interference effects with dual- and triple-echo gradient-recalled-echo Dual/Triple GRE) sequences and to test the robustness of these sequences after iron overloading. Materials and Methods Forty type-2 diabetic patients underwent LMF measurement by 3.0T 1H magnetic resonance spectroscopy (corrected for T1 and T2 decays) as the reference standard and liver fat fraction (%Fat) measurement by four Dual/Triple GRE sequences with 20° and 60° flip angle (α), corrected for T1 recovery. The same four sequences were repeated in eight patients after ferumoxide injection. Corrections for systematic errors…

Molecular Ruby under Pressure

2018

The intensely luminescent chromium(III) complexes [Cr(ddpd)2 ]3+ and [Cr(H2 tpda)2 ]3+ show surprising pressure-induced red shifts of up to -15 cm-1  kbar-1 for their sharp spin-flip emission bands (ddpd=N,N'-dimethyl-N,N'-dipyridine-2-yl-pyridine-2,6-diamine; H2 tpda=2,6-bis(2-pyridylamino)pyridine). These shifts surpass that of the established standard, ruby Al2 O3 :Cr3+ , by a factor of 20. Beyond the common application in the crystalline state, the very high quantum yield of [Cr(ddpd)2 ]3+ enables optical pressure sensing in aqueous and methanolic solution. These unique features of the molecular rubies [Cr(ddpd)2 ]3+ and [Cr(H2 tpda)2 ]3+ pave the way for highly sensitive optical pressu…