Search results for "FM"
showing 10 items of 626 documents
A neoepitope generated by an FLT3 internal tandem duplication (FLT3-ITD) is recognized by leukemia-reactive autologous CD8+ T cells.
2006
Abstract The FLT3 receptor tyrosine kinase is expressed in more than 90% of acute myelogeneous leukemias (AMLs), up to 30% of which carry an internal tandem duplication (ITD) within the FLT3 gene. Although varying duplication sites exist, most FLT3-ITDs affect a single protein domain. We analyzed the FLT3-ITD of an AML patient for encoding HLA class I–restricted immunogenic peptides. One of the tested peptides (YVDFREYEYY) induced in vitro autologous T-cell responses restricted by HLA-A*0101 that were also detectable ex vivo. These peptide-reactive T cells recognized targets transfected with the patient's FLT3-ITD, but not wild-type FLT3, and recognized the patient's AML cells. Our results …
Know your full potential: Quantitative Kelvin probe force microscopy on nanoscale electrical devices
2018
In this study we investigate the influence of the operation method in Kelvin probe force microscopy (KPFM) on the measured potential distribution. KPFM is widely used to map the nanoscale potential distribution in operating devices, e.g., in thin film transistors or on cross sections of functional solar cells. Quantitative surface potential measurements are crucial for understanding the operation principles of functional nanostructures in these electronic devices. Nevertheless, KPFM is prone to certain imaging artifacts, such as crosstalk from topography or stray electric fields. Here, we compare different amplitude modulation (AM) and frequency modulation (FM) KPFM methods on a reference s…
ANALISI DI RISCHIO DELL’IMPIANTO SPERIMENTALE “SELECTIVE PRODUCTION OF EXOTIC SPECIES” (SPES) DELL’INFN DI LEGNARO
Il progetto di ricerca denominato EURISOL (European Isotope Separation On-Line Radioactive Ion Beam Facility), che vede coinvolti i principali laboratori di ricerca nucleari europei, è rivolto allo studio di progettazione e fattibilità di un impianto per la produzione di fasci di nuclei radioattivi posizionati nella cosiddetta “terra incognita” della carta dei nuclidi. Lo scopo principale è l’esplorazione della materia esotica (nuclei caratterizzati da un eccesso difetto di neutroni), con le sue possibili implicazioni nell’ambito della ricerca di base della fisica nucleare, nelle applicazioni in campo medico e dell’astrofisica, e ancora nello studio dei materiali utilizzati nei reattori nuc…
Progettazione e sviluppo del software R.A.D. per analisi FMECA
2012
Ad oggi l’analisi FMECA (Failure Modes, Effects and Criticality Analysis) si è dimostrata uno strumento di indagine molto utile per lo studio dell’affidabilità dei componenti dei vari sistemi di un impianto. Tuttavia, l’applicazione sistematica di tale metodologia, anche nel caso di impianti relativamente semplici, risulta onerosa in termini di risorse necessarie ai fini della sua conduzione e gestione. A supporto dell’analisi, esiste una buona varietà di software sviluppati per lo scopo, tuttavia spesso essi presentano alcune funzionalità selettive essendo dedicati all’impiego in ambiti specifici. Alla luce di tale limitazione si è pensato di realizzare e mettere a punto un software sempli…
CORRELAZIONE TRA FEBBRE MEDITERRANEA FAMILIARE, MALATTIA DI FABRY E GENOTIPI DI SAA1
Familial Mediterranean Fever and Diet: A Narrative Review of the Scientific Literature
2022
Background: Familial Mediterranean fever (FMF) is an inherited autoinflammatory disease characterized by short acute attacks, with an as yet unknown cause. Several authors have investigated the role of some foods as potential triggers. This narrative review aims to analyze the correlation between diet and FMF clinical outcomes. Methods: The review was carried out following PRISMA statement guidelines, including all cross-sectional, case-crossover, and trial studies written in English and conducted between 1974 and 2022. Results: Overall, 642 records were identified through PubMed/MEDLINE (292) and Scopus (350), and seven studies were included: three out of seven (43%) studies evaluated FMF …
Estudio de la transformación fibroblasto-miofibroblasto, la senescencia y el metabolismo de fibroblastos aislados de pacientes con fibrosis pulmonar …
2021
La Fibrosis Pulmonar idiopática (FPI) está definida como una neumonía intersticial fibrosante crónica de causa desconocida, progresiva y fatal que afecta fundamentalmente a adultos mayores de 60 años, limitada a los pulmones y asociada con el patrón histopatológico de neumonía intersticial usual (NIU). La ausencia de manifestaciones específicas de la FPI supone un obstáculo para su detección temprana. Es una enfermedad de diagnóstico difícil y tardío, con un abordaje terapéutico de eficacia reducida. Estas características suscitan la necesidad de encontrar nuevos biomarcadores asociados a la fibrosis y nuevas dianas terapéuticas para un diagnóstico temprano e incrementar la calidad y espera…
Diffusion map for clustering fMRI spatial maps extracted by Indipendent Component Analysis
2013
Functional magnetic resonance imaging (fMRI) produces data about activity inside the brain, from which spatial maps can be extracted by independent component analysis (ICA). In datasets, there are n spatial maps that contain p voxels. The number of voxels is very high compared to the number of analyzed spatial maps. Clustering of the spatial maps is usually based on correlation matrices. This usually works well, although such a similarity matrix inherently can explain only a certain amount of the total variance contained in the high-dimensional data where n is relatively small but p is large. For high-dimensional space, it is reasonable to perform dimensionality reduction before clustering.…
Synergetic and redundant information flow detected by unnormalized Granger causality: application to resting state fMRI
2015
Objectives: We develop a framework for the analysis of synergy and redundancy in the pattern of information flow between subsystems of a complex network. Methods: The presence of redundancy and/or synergy in multivariate time series data renders difficult to estimate the neat flow of information from each driver variable to a given target. We show that adopting an unnormalized definition of Granger causality one may put in evidence redundant multiplets of variables influencing the target by maximizing the total Granger causality to a given target, over all the possible partitions of the set of driving variables. Consequently we introduce a pairwise index of synergy which is zero when two in…
Generation of energy selective excitations in quantum hall edge states
2011
We operate an on-demand source of single electrons in high perpendicular magnetic fields up to 30T, corresponding to a filling factor below 1/3. The device extracts and emits single charges at a tunable energy from and to a two-dimensional electron gas, brought into well defined integer and fractional quantum Hall (QH) states. It can therefore be used for sensitive electrical transport studies, e.g. of excitations and relaxation processes in QH edge states.