Search results for "FORS"

Cyclic AMP elevating agents and nitric oxide modulate angiotensin II-induced leukocyte-endothelial cell interactionsin vivo

2001

Angiotensin (Ang-II) is a key molecule in the development of cardiac ischaemic disorders and displays proinflammatory activity in vivo. Since intracellular cyclic nucleotides elevating agents have proved to be effective modulators of leukocyte recruitment, we have evaluated their effect on Ang-II-induced leukocyte-endothelial cell interactions in vivo using intravital microscopy within the rat mesenteric microcirculation. Pretreatment with iloprost significantly inhibited (1 nM) Ang-II-induced increase in leukocyte rolling flux, adhesion and emigration at 60 min by 96, 92 and 90% respectively, and returned leukocyte rolling velocity to basal levels. Pretreatment with salbutamol or co-superf…

The cAMP Pathway Sensitizes VR1 Expressed in Oocytes from <i>Xenopus laevis</i> and in CHO Cells

2003

The vanilloid receptor 1 (VR1) is a heat-activated cation channel which also responds to capsaicin and other chemical stimuli. Protein kinase C has a stimulatory effect on VR1 activity, either alone or after activation with capsaicin. The influence of the cAMP-signaling pathway on the effects of capsaicin is controversial. To clarify this, the actions of capsaicin and the modulatory effects of forskolin, pCPT-cAMP, and isobutylmethylxanthine were studied in <i>Xenopus laevis</i> oocytes expressing rat VR1 and in CHO cells expressing human VR1. Capsaicin activated the VR1 channel and increased the intracellular calcium concentration. The effects of capsaicin were enhanced by fors…

Direito à justificação - dever de justificação: reflexões sobre um modus de fundamentação dos direitos humanos

2012

Neste texto, discute-se a concepção desenvolvida por Rainer Forst do "direito à justificação", um princípio filosófico básico dos direitos humanos presente na tradição da ideia kantiana de "razão pura prática". Forst procura demonstrar que o reconhecimento do outro, como um ser finito e com necessidades, fundamenta diante de mim um direito a razões justificadoras. A dignidade do outro me obriga a agir perante ele apenas conforme tais razões, as quais ele pode compreender e aprovar. No texto, demonstram-se também alguns pontos fracos desse princípio de Forst que, sobretudo, resultam da insolúvel tensão entre uma teoria da razão prática e uma teoria do reconhecimento. Além disso, defende-se a…

Monitoraggio visivo su palmacee potenziali ospiti del Punteruolo rosso e del Castnide delle palme presenti in Sicilia

2009

Disinformation in Facebook Ads in the 2019 Spanish General Election Campaigns

2021

Producción Científica

Journalists’ Associations as Political Instruments in Central and Eastern Europe

2017

This editorial provides the overall context for the five cases—three national and two international—covered in this thematic issue. While the cases are from Central and Eastern Europe (CEE), they highlight fundamental questions of journalism everywhere, including contradictions between freedom and control, professionalism and politics, individual and collective. The associations of journalists serve as very useful platforms to study these questions, especially at historical turning points when the whole political system changed, as happened twice in CEE after World War II.

Facebook’s Emotional Contagion Experiment as a Challenge to Research Ethics

2016

This article analyzes the ethical discussion focusing on the Facebook emotional contagion experiment published by the <em>Proceedings of the National Academy of Sciences</em> in 2014. The massive-scale experiment manipulated the News Feeds of a large amount of Facebook users and was successful in proving that emotional contagion happens also in online environments. However, the experiment caused ethical concerns within and outside academia mainly for two intertwined reasons, the first revolving around the idea of research as manipulation, and the second focusing on the problematic definition of informed consent. The article concurs with recent research that the era of social med…

Localizing the politics of privacy in communication and media research

2020

While previous communication and media research has largely focused on either studying privacy as personal boundary management or made efforts to investigate the structural (legal or economic) condition of privacy, we observe an emergent body of research on the political underpinnings of privacy linking both aspects. A pronounced understanding of the politics of privacy is however lacking. In this contribution, we set out to push this forward by mapping four communication and media perspectives on the political implications of privacy. In order to do so, we recur on Barry’s (2002) distinction of the political and the politics and outline linkages between individual and structural dimensions…

The Politics of Privacy - a Useful Tautology

2020

While communication and media studies tend to define privacy with reference to data security, current processes of datafication and commodification substantially transform ways of how people act in increasingly dense communicative networks. This begs for advancing research on the flow of individual and organizational information considering its relational, contextual and, in consequence, political dimensions. Privacy, understood as the control over the flow of individual or group information in relation to communicative actions of others, frames the articles assembled in this thematic issue. These contributions focus on theoretical challenges of contemporary communication and media privacy …

Pathogens and host immunity in the ancient human oral cavity.

2014

Calcified dental plaque (dental calculus) preserves for millennia and entraps biomolecules from all domains of life and viruses. We report the first high-resolution taxonomic and protein functional characterization of the ancient oral microbiome and demonstrate that the oral cavity has long served as a reservoir for bacteria implicated in both local and systemic disease. We characterize: (i) the ancient oral microbiome in a diseased state, (ii) 40 opportunistic pathogens, (iii) the first evidence of ancient human-associated putative antibiotic resistance genes, (iv) a genome reconstruction of the periodontal pathogen Tannerella forsythia, (v) 239 bacterial and 43 human proteins, allowing co…