Search results for "FS"

A DNA region ofTorulaspora delbrueckii containing theHIS3 gene: sequence, gene order and evolution

2003

We cloned a genomic DNA fragment of the yeast Torulaspora delbrueckii by complementation of a Saccharomyces cerevisiae his3 mutant strain. DNA sequence analysis revealed that the fragment contained two complete ORFs, which share a high similarity with S. cerevisiae His3p and Mrp51p, respectively. The cloned TdHIS3 gene fully complemented the his3 mutation of S. cerevisiae, confirming that it encodes for the imidazoleglycerol-phosphate dehydrate of T. delbrueckii. Two additional ORFs, with a high homology to S. cerevisiae PET56 and DED1 genes, were mapped upstream and downstream from TdHIS3 and TdMRP51, respectively. This genetic organization is analogous to that previously found in Saccharo…

A genomic study of the inter-ORF distances in Saccharomyces cerevisiae.

2006

The genome of eukaryotic microbes is usually quite compacted. The yeast Saccharomyces cerevisiae is one of the best-known examples. Open reading frames (ORFs) occupy about 75% of the total DNA sequence. The existence of other, non-protein coding genes and other genetic elements leaves very little space for gene promoters and terminators. We have performed an in silico study of inter-ORF distances that shows that there is a minimum distance between two adjacent ORFs that depends on the relative orientation between them. Our analyses suggest that different kinds of promoters and terminators exist with regard to their length and ability to overlap each other. The experimental testing of some p…

Valutazione della vita a fatica di giunti complessi saldati tramite Friction Stir Welding

2010

Zasp/Cypher internal ZM-motif containing fragments are sufficient to co-localize with α-actinin—Analysis of patient mutations

2005

Z-band alternatively spliced PDZ-containing protein (ZASP/Cypher) has an important role in maintaining Z-disc stability in striated and cardiac muscle. ZASP/Cypher interacts through its PDZ domain with the major Z-disc actin cross-linker, alpha-actinin. ZASP/Cypher also has a conserved sequence called the ZM-motif, and it is found in two alternatively spliced exons 4 and 6. We have shown earlier that the ZM-motif containing internal regions of two related proteins ALP and CLP36 interact with alpha-actinin rod region, and that the ZM-motif is important in targeting ALP to the alpha-actinin containing structures in cell. Here, we show that the ZASP/Cypher internal fragments containing either …

Phosphorylation of the Usher syndrome 1G protein SANS controls Magi2-mediated endocytosis.

2014

Item does not contain fulltext The human Usher syndrome (USH) is a complex ciliopathy with at least 12 chromosomal loci assigned to three clinical subtypes, USH1-3. The heterogeneous USH proteins are organized into protein networks. Here, we identified Magi2 (membrane-associated guanylate kinase inverted-2) as a new component of the USH protein interactome, binding to the multifunctional scaffold protein SANS (USH1G). We showed that the SANS-Magi2 complex assembly is regulated by the phosphorylation of an internal PDZ-binding motif in the sterile alpha motif domain of SANS by the protein kinase CK2. We affirmed Magi2's role in receptor-mediated, clathrin-dependent endocytosis and showed tha…

Offshore wind turbine operations and maintenance: A state-of-the-art review

2021

Abstract Operations and maintenance of offshore wind turbines (OWTs) play an important role in the development of offshore wind farms. Compared with operations, maintenance is a critical element in the levelized cost of energy, given the practical constraints imposed by offshore operations and the relatively high costs. The effects of maintenance on the life cycle of an offshore wind farm are highly complex and uncertain. The selection of maintenance strategies influences the overall efficiency, profit margin, safety, and sustainability of offshore wind farms. For an offshore wind project, after a maintenance strategy is selected, schedule planning will be considered, which is an optimizati…

Organisation and Context, Efficiency and Equity of Educational Systems: what PISA tells us

2005

05065http://www.wwwords.co.uk/eerj/; International audience; After describing both average scores, dispersion, and social inequalities in achievement in the various countries included in the latest Programme for International Student Assessment (PISA) study, this article relates those ‘products' to country economic and cultural characteristics. It then explores relations between student scores and a number of institutional characteristics of countries' educational systems. Results show that relations exist between average scores and certain institutional or pedagogical practices such as grade repeating or tracking. A high degree of social inequality in achievement proves to be associated wi…

Breast cancer screening : socioeconomic factors influencing the participation and screening round adequacy

2013

Mammography screening allowed breast tumors detection in early stage while treatments are less aggressive. Despite the fact that organized mammography screening has been free of charge for the target population since 2004 in France, the participation rate to the programme remains low.The aim of the studies was to investigate individual and area-level socioeconomic factors explaining low breast cancer screening attendance, individual factors influencing mammography screening round adequacy and to assess the evidence of screening round adequacy in the discovery of breast tumors.The results showed that women living in most deprived areas or rural areas, those covered by self-employed insurance…

Prototyping algorithm for retrieving FAPAR using MSG data in the context of the LSA SAF project

2007

This paper describes the prototyping algorithm developed for retrieving the Fraction of Absorbed Photosynthetically Active Radiation (FAPAR) using MSG data in the framework of satellite application facility on land surface analysis (LSA SAF). The prototyping relies on the Roujean and Breon (1995) method, which is based on simulations of visible and near infrared reflectance values in an optimal geometry. A relationship is found between a vegetation index and daily FAPAR The algorithm has been applied to one year of MSG BRDF data since August 2005, using a temporal frequency of 5-days, and then validated against a set of operational satellite FAPAR products such as MODIS, MERIS, SeaWiFS and …

Ne sous-estimons pas le risque à long terme de second cancer pulmonaire après exérèse chirurgicale d'un cancer du poumon non à petites cellules

2019

Etat de la question Plusieurs etudes ont montre que les survivants d’un cancer du poumon sont a haut risque de developper un second cancer broncho-pulmonaire (SCBP). L’evaluation du risque de SPBC au cours du temps a d’importante repercussion sur la strategie de surveillance post-chirurgicale des cancers du poumon non a petites cellules (CPNPC). L’objectif principal de cette etude etait de mesurer le risque de SCP sur le long terme en tenant compte du risque competitif de deces. Materiel et methodes Le risque cumule de SCBP a ete estime a l’aide de l’incidence cumulee chez des patients operes en resection complete d’un CPNPC de stade I a III diagnostiques entre 2002 et 2015 et recenses par …