Search results for "Futur"

showing 10 items of 542 documents

2017

Aqueous humour (AH) is an important biologic fluid that maintains normal intraocular pressure and contains proteins that regulate the homeostasis of ocular tissues. Any alterations in the protein compositions are correlated to the pathogenesis of various ocular disorders. In recent years, gender-based medicine has emerged as an important research focus considering the prevalence of certain diseases, which are higher in a particular sex. Nevertheless, the inter-gender variations in the AH proteome are unknown. Therefore, this study endeavoured to characterize the AH proteome to assess the differences between genders. Thirty AH samples of patients who underwent cataract surgery were categoriz…

0301 basic medicineMultidisciplinaryFuture studiesAqueous humourInflammationBiologyProteomicsBioinformaticsPathogenesis03 medical and health sciences030104 developmental biologyImmune systemProteomebiology.proteinmedicineAntibodymedicine.symptomPLOS ONE
researchProduct

Metilazione del DNA in artrite reumatoide

2005

Lo stato di metilazione del DNA genomico e del gene PTHrP è stato valutato con tecniche molecolari e citogenetiche in artrite reumatoide (AR), patologia autoimmune caratterizzata anche da alta incidenza di linfomi e da ipercalcemia per overespressione del gene PTHrP. La metilazione del DNA, infatti, ha un ruolo critico nello sviluppo delle malattie neoplastiche; il gene PTHrP avendo tre promotori uno dei quali contiene un’isola CpG è un buon candidato per la deregolazione da alterato pattern di metilazione locale. Le indagini sulla metilazione genomica, condotte su DNA estratto da sangue periferico di pazienti e di donatori e amplificato in reazioni di Methylation-Sensitive Arbitrarily Prim…

Settore BIO/18 - Geneticainstead chromosomes of controls were almost uniformly decorated by brilliant grains. Studies on methylation of PTHrP gene promoter 2 performed on five CpG island internal sites using the Methylation-Sensitive Restriction Endonuclease Multiplex (MSREM)-PCR showed that one of the sites nearest the trascription starting point is heavy methylated in a significantly high number of RA patients. Thus RA seems to be characterized by genomewide hypomethylation associated with local hypermethylation like the most part of tumors. This result raises the possibility that susceptibility to lymphomas is related to abnormal DNA methylation levels and suggests the opportunity to evaluate the DNA methylation status in RA patientin fact the demethylating therapies together with diet and life style can act towards an increase of tumor risk. Future studies using a larger number of subjects could confirm these findings.Rheumatoid Arthritis (RA) is a chronic multisystem inflammatory disease characterized by high recurrence of lymphomas as well as hypercalcemia due to PTHrP overexpression. Because of DNA methylation plays a critical role in development of neoplasias we determined in RA patients the global DNA methylation status and local methylation pattern of the CpG island of one of the three promoters of PTHrP gene utilizing molecular and cytogenetic techniques. Investigations performed on DNA from peripheral blood of patients and donors amplified by Methylation-Sensitive Arbitrarily Primed (MeS-AP)-PCR indicated that RA is strongly associated with global DNA hypomethylation. Similarly chromosomal DNA methylation pattern analysis by indirect immunofluorescence technique with anti 5-methylcitosine antibody showed all peripheral lymphocyte metaphases from RA patients with chromosomes weakly fluorescent without discrete grain
researchProduct

Metas evolutivas y representaciones del futuro en personas mayores sanas y con enfermedades crónicas

2012

Los seres humanos somos organismos intencionales, orientados hacia metas, perfilados hacia el futuro, poseemos ilusiones, expectativas, esperanzas, temores o amenazas que orientan nuestras acciones, dan significado e influyen la vida, para que seamos, hasta cierto punto, arquitectos del propio desarrollo. Las metas, su mantenimiento y cambio en diferentes situaciones, son un medio de adaptación fundamental a las diferentes circunstancias y contextos que nos toca vivir. Esa estructura de metas va ajustándose, para aprovechar las oportunidades que están a nuestro alcance o mitigar el impacto de los obstáculos y adversidades. El envejecimiento, como proceso generalmente asociado a una mayor pr…

metas evolutivas representaciones de futuro adultos mayores enfermedades crónicas estado de saludUNESCO::CIENCIAS DE LA VIDA:PSICOLOGÍA [UNESCO]UNESCO::PSICOLOGÍA:CIENCIAS DE LA VIDA [UNESCO]
researchProduct

Event-related potentials to unattended changes in facial expressions: detection of regularity violations or encoding of emotions?

2013

Visual mismatch negativity (vMMN), a component in event-related potentials (ERPs), can be elicited when rarely presented “deviant” facial expressions violate regularity formed by repeated “standard” faces. vMMN is observed as differential ERPs elicited between the deviant and standard faces. It is not clear, however, whether differential ERPs to rare emotional faces interspersed with repeated neutral ones reflect true vMMN (i.e., detection of regularity violation) or merely encoding of the emotional content in the faces. Furthermore, a face-sensitive N170 response, which reflects structural encoding of facial features, can be modulated by emotional expressions. Owing to its similar latency …

medicine.medical_specialtyvisual mismatch negativityFuture studiesMismatch negativityfacial expressionsStimulus (physiology)Audiology050105 experimental psychologylcsh:RC321-571Developmental psychology03 medical and health sciencesBehavioral Neuroscienceequiprobable condition0302 clinical medicineEvent-related potentialvisuaalinen poikkeavuusnegatiivisuusmedicineoddball condition0501 psychology and cognitive sciencesEmotional expressionOriginal Research Articleilmeetlcsh:Neurosciences. Biological psychiatry. Neuropsychiatryta515Biological Psychiatryta113Facial expression05 social sciencesEqual probabilityriippumattomien komponenttien analyysikasvonilmeetPsychiatry and Mental healthitsenäisten komponenttien analyysiNeuropsychology and Physiological Psychologymedicine.anatomical_structureNeurologyindependent component analysisScalpPsychology030217 neurology & neurosurgeryNeuroscienceFrontiers in Human Neuroscience
researchProduct

Diagnóstico en educación y transiciones

2014

RESUMENEl artículo presenta una reflexión sobre el papel del Diagnóstico en Educación en las transiciones. Las premisas clásicas del diagnóstico tradicional se desmoronan con la incorporación de nuevas consideraciones relacionadas con el carácter procesual, la impredecibilidad del futuro y cambios sociales y con las nuevas tendencias metodológicas del diagnóstico. Desde una perspectiva sistémica, se sugiere un diagnóstico centrado en dos áreas prioritarias: a) la exploración de las causas que impiden el desarrollo de los individuos y el proceso de transformación de sus habilidades y, b) el compromiso paralelo con una transformación educativa y social. Asimismo, el artículo repasa el sentido…

Process (engineering)habilidadmedia_common.quotation_subjectPerspective (graphical)Social changeaprendizajeexperimentaciónPriority areasEducationEpistemologydiagnósticoSocial transformationPersonalitydesarrollo de la personalidadpsicología de la educaciónPsychologyEmpowermentFutures contractApplied Psychologymedia_commonpsicología evolutiva
researchProduct

Fifth Generation Networking Principles for a Service Driven Future Internet Architecture

2010

Published version of an article published in Wireless Personal Communications, vol. 57:393-411. Also available from the publisher at: http://dx.doi.org/10.1007/s11277-010-0076-7 The vision of all-IP networks where IP forms the simple common layer understandable across the whole network has undeniable advantages. However, such simplicity comes as a major hurdle to flexibility and functionality to the architecture. This is evident from the increasingly numerous and complex engineering solutions and optimizations required to accommodate essential qualities like mobility, security, realtime communication support etc or to mitigate the shortcomings inherent in the 'traditional Internet' architec…

Enterprise architecture frameworkComputer sciencecomputer.internet_protocolDistributed computingSolution architectureInteroperabilityCore networkcomputer.software_genreDatabase-centric architectureVDP::Mathematics and natural science: 400::Information and communication science: 420::Theoretical computer science programming languages and programming theory: 421Next-generation networkReference architectureElectrical and Electronic EngineeringNetwork architecturebusiness.industryQuality of serviceService-oriented architectureComputer Science ApplicationsFuture Internet network architecture service oriented architecture ROSAApplications architectureOpen network architectureThe InternetWeb serviceSpace-based architecturebusinesscomputerWireless Personal Communications
researchProduct

Sombras en Lisboa

2000

TelecomunicacionesRenacionalización liberalLisboaInvestigadoresVidal-Beneyto JoséModelo europeoInvestigación y desarrolloDinamizaciónCrecimientoEUROPACohesión socialPublicaciones: Obra periodística: Columnas y artículos de opiniónLiberalización totalUnión EuropeaPolítica económicaCIENCIAFuturo europeoNueva economíaConsejo EuropeoCompetitividadSector científicoMinistros de Investigación
researchProduct

Runoff Generation in Badlands

2019

Capítulo 5.

Water erosion010504 meteorology & atmospheric sciencesRunoffClimate change01 natural sciences[SDU] Sciences of the Universe [physics]Overland flowBadlandsFlash floodClimate changeComputingMilieux_MISCELLANEOUS0105 earth and related environmental sciencesLand useGlobal change04 agricultural and veterinary sciences15. Life on landFuture climate6. Clean waterCurrent (stream)13. Climate action[SDU]Sciences of the Universe [physics]040103 agronomy & agriculture0401 agriculture forestry and fisheriesEnvironmental scienceWater resource managementSurface runoff
researchProduct

Coauthorship Networks and Institutional Collaboration in Revista Española de Cardiología Publications

2007

The aim of this study was to analyze the patterns of investigator and institutional collaboration in papers published in the Revista Española de Cardiología.Details of coauthorship and institutional collaboration involved in articles published in the Revista Española de Cardiología in the period 2000-2005 were recorded and a collaboration index was derived. Collaboration networks were identified using the TextToPajek and PAJEK software tools.Of the 980 papers analyzed, 95.1% had been authored by two or more individuals and 51.43% involved institutional collaboration. The overall collaboration index was 6.23 (standard deviation [SD] 3.1). There was a significant statistical relationship (P.0…

Gerontologybusiness.industryInterprofessional RelationsCardiologyLibrary scienceGeneral MedicineDatabases BibliographicAuthorshipScientific productivityFuture studyInterinstitutional RelationsBibliometricsSpainHumansMedicineCooperative BehaviorPeriodicals as TopicbusinessRevista Española de Cardiología (English Edition)
researchProduct

Possession and volition in the development of modal meanings: a case-study from Sicilian

2019

This article analyses two Sicilian modal constructions involving vuliri 'want' + infinitive and aviri a ‘have to’ + infinitive. They are used to express modal values, both non-epistemic and epistemic, and futurity. Based on Langacker's Cognitive Grammar assumptions, we describe the semantic network associated with each modal, as well as their semantic overlap. In addition, we describe how modal values interact with temporal-aspectual inflection. Our analysis shows that the epistemic values of vuliri are quite peripheral, while aviri a shows a high degree of polysemy, both in the non-epistemic and in the more abstract epistemic domain. The non-epistemic-to-epistemic shifts depend on the cont…

futureCognitive grammarSicilian modalVerbsicilian modalspossessionvolitionGrammaticalizationLinguisticsSettore L-LIN/01 - Glottologia E Linguisticalcsh:Philology. LinguisticsModallcsh:P1-1091subjectificationPossession (linguistics)Cognitive GrammarInflectionmodalityInfinitivePolysemySicilian modals; Cognitive grammar; Subjectification; Modality; FutureMathematicsJournal of Contemporary Philology, Ss Cyril and Methodius University, B Koneski Faculty of Philology
researchProduct