Search results for "G6"
showing 9 items of 19 documents
Deficit di G6PD: diagnosi fenotipica e genetica. Prevalenza e caratterizzazione molecolare delle varianti genetiche nella popolazione pediatrica sici…
2015
Valutazione dei genotipi G6PD nella popolazione Siciliana e identificazione di una nuova variante: “G6PD*Palermo R257M”.
2008
La deficienza enzimatica di G6PDH è uno dei più comuni disordini nella popolazione siciliana in quanto più di 400 milioni di persone ne sono affette. Al fine di valutare la reale prevalenza dei casi nel nostro territorio presentiamo i dati di uno studio di genotipizzazione del locus G6PD (Xq28). 349 soggetti Siciliani di sesso maschile affetti da deficienza di G6PDH sono stati tipizzati secondo varie metodiche. Gli approcci di laboratorio sono: RFLPs (NlaIII, BclI, PstI e BspHI), PCR-Reverse Dot Blot (RDB) ed il sequenziamento diretto del gene. Le prime metodiche sono utili per definire le mutazioni già descritte e comunque le più comuni; il sequenziamento diretto è determinante per la valu…
Cross-Commodity Spot Price Modeling with Stochastic Volatility and Leverage For Energy Markets
2013
Spot prices in energy markets exhibit special features, such as price spikes, mean reversion, stochastic volatility, inverse leverage effect, and dependencies between the commodities. In this paper a multivariate stochastic volatility model is introduced which captures these features. The second-order structure and stationarity of the model are analyzed in detail. A simulation method for Monte Carlo generation of price paths is introduced and a numerical example is presented.
A nonstationary cylinder-based model describing group dispersal in a fragmented habitat
2014
International audience; A doubly nonstationary cylinder-based model is built to describe the dispersal of a population from a point source. In this model, each cylinder represents a fraction of the population, i.e., a group. Two contexts are considered: The dispersal can occur in a uniform habitat or in a fragmented habitat described by a conditional Boolean model. After the construction of the models, we investigate their properties: the first and second order moments, the probability that the population vanishes, and the distribution of the spatial extent of the population.
Surfaces of minimal degree of tame representation type and mutations of Cohen–Macaulay modules
2017
We provide two examples of smooth projective surfaces of tame CM type, by showing that any parameter space of isomorphism classes of indecomposable ACM bundles with fixed rank and determinant on a rational quartic scroll in projective 5-space is either a single point or a projective line. For surfaces of minimal degree and wild CM type, we classify rigid Ulrich bundles as Fibonacci extensions. For the rational normal scrolls S(2,3) and S(3,3), a complete classification of rigid ACM bundles is given in terms of the action of the braid group in three strands.
Glucose 6-phosphate dehydrogenase Palermo R257M: a novel variant associated with chronic non-spherocytic haemolytic anaemia
2010
Prolonging in utero-like oxygenation after birth diminishes oxidative stress in the lung and brain of mice pups☆
2013
Background Fetal-to-neonatal transition is associated with oxidative stress. In preterm infants, immaturity of the antioxidant system favours supplemental oxygen-derived morbidity and mortality. Objectives To assess if prolonging in utero-like oxygenation during the fetal-to-neonatal transition limits oxidative stress in the lung and brain, improving postnatal adaptation of mice pups. Material and methods Inspiratory oxygen fraction (FiO2) in pregnant mice was reduced from 21% (room air) to 14% (hypoxia) 8–12 h prior to delivery and reset to 21% 6–8 h after birth. The control group was kept at 21% during the procedure. Reduced (GSH) and oxidized (GSSG) glutathione and its precursors [γ-glut…
Ruolo citotossico del cannabinoide sintetico WIN55,212-2 in cellule di osteosarcoma MG63: coinvolgimento della proteina SPARC.
Il cannabinoide sintetico WIN 55,212-2 è un potente agonista sintetico del recettore per i cannabinoidi con spiccate potenzialità antitumorali. Gli esperimenti riportati in questa tesi sono stati condotti per delineare gli effetti indotti dal WIN sulla proliferazione, la migrazione e la sensibilizzazione alla morte indotta dalla citochina TRAIL in cellule di osteosarcoma umano MG63. I risultati ottenuti mostrano che il WIN induce un blocco del ciclo cellulare in fase G2/M che è associato all’induzione dei principali markers di ER stress (GRP78, CHOP e TRB3). Nelle cellule trattate abbiamo inoltre osservato la conversione della forma citosolica del marker autofagosomale LC3-I in LC3-II (la f…
Moderate overexpression of glucose-6-phosphate dehydrogenase improves healthspan in mice. Implications in skeletal muscle regeneration
2019
An enormous increment in the average lifespan of diverse populations occurred worldwide in the 20th century. In the last 10–15 years, the importance has changed from extending average and even maximal longevity to favoring healthy aging, and many researchers have focused their studies on the aim at extending healthspan. Prolonging lifespan without taking care of improving healthspan can derive in a long time of living with disabilities and constitutes a risk factor for the old population to suffer a higher prevalence of aging-related diseases. Indeed, modern disease treatments frequently diminish mortality without any effect on the deterioration of overall health. Understanding the mechanis…