Search results for "Genoma"
showing 10 items of 40 documents
The genome sequencing of an albino Western lowland gorilla reveals inbreeding in the wild
2013
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.-- et al.
Nearly Complete Genome Sequences of Human Norovirus Belonging to Several Genotypes from Valencia, Spain
2019
Human noroviruses are responsible for most nonbacterial acute gastroenteritis cases. The GII.2, GII.4, and GII.17 genotypes of human noroviruses have recently arisen as the most frequent genotypes found in humans worldwide. We report here seven nearly complete genomes of these genotypes from patients with acute gastroenteritis in Valencia, Spain.
Machine Learning-Based Approach Highlights the Use of a Genomic Variant Profile for Precision Medicine in Ovarian Failure
2021
Ovarian failure (OF) is a common cause of infertility usually diagnosed as idiopathic, with genetic causes accounting for 10–25% of cases. Whole-exome sequencing (WES) may enable identifying contributing genes and variant profiles to stratify the population into subtypes of OF. This study sought to identify a blood-based gene variant profile using accumulation of rare variants to promote precision medicine in fertility preservation programs. A case–control (n = 118, n = 32, respectively) WES study was performed in which only non-synonymous rare variants <
Use of next generation sequencing technologies for the diagnosis and epidemiology of infectious diseases
2020
[ES]: Por primera vez, la tecnología de secuenciación masiva permite acceder a la información genómica a un precio y a una escala tales, que se está implementado en la práctica clínica y epidemiológica rutinaria. Los obstáculos para dicha implementación son todavía muchos. Sin embargo, ya existen muchos ejemplos de las grandes ventajas que supone en comparación con métodos anteriores. Esto es, sobre todo, porque con una sola determinación podemos obtener simultáneamente información epidemiológica del microorganismo causante, así como de su perfil de resistencias, si bien estas ventajas están más o menos desarrolladas según el patógeno considerado. En esta revisión se repasan varios ejemplos…
Local adaptation in populations of Mycobacterium tuberculosis endemic to the Indian Ocean Rim
2021
24 páginas, 3 figuras, 1 tabla. The sequence data generated by this study has been deposited on SRA (https://www.ncbi.nlm.nih.gov/sra) under the accession number PRJNA670836. Extended data is available here: https://github.com/fmenardo/MTBC_L1_L3. DOI: https://doi.org/10.5281/zenodo.4609804 (Menardo, 2021).
VISMapper: ultra-fast exhaustive cartography of viral insertion sites for gene therapy
2017
The possibility of integrating viral vectors to become a persistent part of the host genome makes them a crucial element of clinical gene therapy. However, viral integration has associated risks, such as the unintentional activation of oncogenes that can result in cancer. Therefore, the analysis of integration sites of retroviral vectors is a crucial step in developing safer vectors for therapeutic use. Here we present VISMapper, a vector integration site analysis web server, to analyze next-generation sequencing data for retroviral vector integration sites. VISMapper can be found at: http://vismapper.babelomics.org . Because it uses novel mapping algorithms VISMapper is remarkably faster t…
Nearly Complete Genome Sequence of a Human Norovirus GII.P17-GII.17 Strain Isolated from Brazil in 2015
2019
Human noroviruses are the most common cause of nonbacterial acute gastroenteritis worldwide. We report here the nearly complete genome sequence (7,551 nucleotides) of a human norovirus GII.P17-GII.17 strain detected in July 2015 in the stool sample from an adult with acute gastroenteritis in Brazil.
Epidemiología molecular y genómica de aislados resistentes de Pseudomonas aeruginosa de origen hospitalario.
2019
Pseudomonas aeruginosa es un patógeno frecuente en entornos hospitalarios que acumula multitud de resistencias a antibióticos. Ante la dificultad de encontrar tratamiento efectivo, los pacientes están mucho tiempo colonizados y aumenta la probabilidad de transmisión. El principal objetivo del presente trabajo ha sido mostrar cómo el estudio evolutivo a nivel de genomas completos puede ser útil para la detección de transmisiones a diferentes niveles. Se decidió aplicar la misma metodología de reconstrucción de la filogenia a partir de las variantes encontradas en genomas completos que además se dataron por métodos bayesianos. Para ello, hemos contado con muestras de P. aeruginosa multirresis…
JAUNIZDALĪTO CEDECEA DAVISAE INFICĒJOŠO BAKTERIOFĀGU IZOLĒŠANA UN RAKSTUROŠANA
2022
Darbā izolētas baktērijas no dažādu rožu dzimtas augļkopības kultūru augu lapām, kuras identificētas ar 16S rRNS gēna sekvenēšanas metodi. Izmantojot šīs baktērijas kā saimniekkultūras, tika izolēti 10 jauni dsDNS bakteriofāgi. Vēlāk ar Cedecea davisae baktēriju izolātu kā saimnieku no notekūdeņu paraugiem tika izolēti vēl 13 fāgi. Tālākai izpētei tika izvēlēts jaunizdalītais Cedecea fāgs Yanou. Fāgs Yanou ir Autographiviridae dzimtai, Teseptimavirus ģintij piederošs lītisks podovīruss ar 40865 bp garu genomu. Tas ir otrs līdz šim zināmais Cedecea ģints fāgs un pirmais raksturotais Cedecea lītiskais podovīruss. Bakteriofāga Yanou pilnais anotētais genoms deponēts GenBank brīvpieejas datubāz…
CARATTERIZZAZIONE METAGENOMICA di MICRORGANISMI E ORGANISMI DEL TERRENO PER UN LORO UTILIZZO COME AGENTI di LOTTA BIOLOGICA CONTRO NEMATODI FITOPARAS…
2014
La microflora della rizosfera riveste un ruolo fondamentale sia nella difesa che nello sviluppo e crescita delle piante. Molti studi hanno dimostrato inoltre che i nematodi sono in grado d’influenzarne la composizione. I batteri a loro volta producono una varietà di composti (antibiotici, nutrienti, esoenzimi e altre molecole segnale), in grado d’indurre ulteriori cambiamenti. L’obiettivo di questo lavoro è stato quello di studiare i cambiamenti nella biodiversità della microflora batterica di un terreno proveniente da un’azienda biologica, conseguenti all'introduzione sperimentale di larve di Meloidogyne incognita e al trattamento con un nematocida (fenamifos). Seguendo un approccio metage…