Search results for "HAP"
showing 10 items of 2767 documents
Synthesis of Polycyclic Indolines utilizing a reduction/cyclization cascade reaction
2021
Subsequent reduction and dearomatizing cyclization reactions open up an entry into the synthesis of novel N-fused polycyclic indolines. The dearomatizing cyclization as key step of the sequence proceeds well with Cu(OTf)2 or TfOH as catalyst. At elevated temperature reduction of nitro-substituted precursors with iron under acidic conditions affords a broad variety of polycyclic indolines directly in a two-step cascade reaction in good to excellent yields. Using the developed protocol, the alkaloids Tryptanthrin and Phaitanthrin C have been prepared. peerReviewed
Optimizing the SYBR green related cyanine dye structure to aim for brighter nucleic acid visualization
2022
In recent years, the studies of RNA and its use for the development of RNA based vaccines have increased drastically. Although cyanine dyes are commonly used probes for studying nucleic acids, in a wide range of applications, there is still a growing need for better and brighter dyes. To meet this demand, we have systematically studied the structure of SYBR green-related cyanine dyes to gain a deeper understanding of their interactions with biomolecules especially how they interact with nucleic acids and the structural components which makes them strongly fluorescent. Herein, five new dyes were synthesized, and their photophysical properties were evaluated. Observations of photophysical cha…
Phytoplankton group identification with chemotaxonomic biomarkers: In combination they do better
2023
Chemotaxonomic biomarkers are needed to monitor and evaluate the nutritional quality of phytoplankton communities. The biomolecules produced by different phytoplankton species do not always follow genetic phylogeny. Therefore, we analyzed fatty acids, sterols, and carotenoids from 57 freshwater phytoplankton strains to evaluate the usability of these biomolecules as chemotaxonomic biomarkers. We found 29 fatty acids, 34 sterols, and 26 carotenoids in our samples. The strains were grouped into cryptomonads, cyanobacteria, diatoms, dinoflagellates, golden algae, green algae, and raphidophytes, and the phytoplankton group explained 61%, 54%, and 89% of the variability of fatty acids, sterols, …
Effects of aerobic and strength training on aerobic capacity, muscle strength, and gene expression of lymphomonocytes in patients with stable CAD
2020
This study examined the effectiveness, suitability, and safety of a mixed interval-type aerobic and strength training program (MIAST) on physical fitness in patients with stable coronary artery disease (CAD) without history of myocardial infarction (MI). Twenty-three patients with stable CAD were randomly assigned to a MIAST (n = 12; mean age 58.6 years) or control (n = 11; 63.3 years) group. The MIAST group participated in the progressive training program twice a week for 21 weeks. Peak oxygen uptake (VO2peak), workload, and exercise time were measured as were maximal muscle strength, serum lipids, glucose concentration, and the cross-sectional area (CSA) of knee extensors. The safety and …
Estejuoksun lajianalyysi ja valmennuksen ohjelmointi
2018
Estejuoksun ominaispiirteet. 3000 m estejuoksu on yksi yleisurheilun arvokilpailujen kestävyysjuoksumatkoista. Nuorten ja aikuisurheilun sarjoissa kilpaillaan myös 2000 metrin matkalla. Estejuoksussa urheilijan tulee ylittää viisi estettä täysinäisen ratakierroksen aikana, joista yksi on vesieste. Estejuoksijan ominaisuudet. Estejuoksijalta vaadittavia ominaisuuksia voidaan pitkälti tarkastella kestävyysjuoksun vaatimusten pohjalta. Estejuoksijalta vaaditaan korkeaa maksimaalista hapenottokykyä ja juoksun taloudellisuutta. Muista kestävyysjuoksijoista poiketen estejuoksija tarvitsee lajinomaista kestävyyttä, nopeus- ja voimaominaisuuksia, sekä lajitaitavuutta päästäkseen korkealle tasolle. …
W poszukiwaniu definicji szczęścia - oblicza szczęścia w percepcji przedszkolaków
2016
This papers aims to present the opinions of 54 kindergarten pupils from Public Kindergarten in Chrząstowice in the Opolskie province regarding how they understand and interpret the concept of happiness. The pupils were asked a number of questions regarding happiness, being happy and/or unhappy, situations when they are either happy or unhappy. The research material was further subjected to a qualitative analysis.
Shape optimization for Stokes problem with threshold slip boundary conditions
2017
This paper deals with shape optimization of systems governed by the Stokes flow with threshold slip boundary conditions. The stability of solutions to the state problem with respect to a class of domains is studied. For computational purposes the slip term and impermeability condition are handled by a regularization. To get a finite dimensional optimization problem, the optimized part of the boundary is described by B´ezier polynomials. Numerical examples illustrate the computational efficiency. peerReviewed
Automated water quality monitoring of humic lakes by using the optical properties of water
2016
Automated water quality monitoring (AWQM) is becoming increasingly common in lakes worldwide. The history of AWQM is relatively short and standard calibration procedures for the measured variables are largely yet to be established. The use of optical AWQM sensors, developed in oceanic environments, raises new questions on the diverse effects which humic compounds may have on the automated optical measurements in inlands waters. The focus of this thesis was to characterize the effects of coloured dissolved organic matter (CDOM) on optical in situ measurements of organic matter (OM) and chlorophyll (Chl) in lakes with varying humic content, and to use AWQM data as a part of traditional monito…
Dynamic Stabilization of the Ligand-Metal Interface in Atomically Precise Gold Nanoclusters Au68 and Au144 Protected by meta-Mercaptobenzoic Acid
2017
Ligand-stabilized, atomically precise gold nanoclusters with a metal core of a uniform size of just 1-3 nm constitute an interesting class of nanomaterials with versatile possibilities for applications due to their size-dependent properties and modifiable ligand layers. The key to extending the usability of the clusters in applications is to understand the chemical bonding in the ligand layer as a function of cluster size and ligand structure. Previously, it has been shown that monodispersed gold nanoclusters, stabilized by meta-mercaptobenzoic acid (m-MBA or 3-MBA) ligands and with sizes of 68-144 gold atoms, show ambient stability. Here we show that a combination of nuclear magnetic reson…
The muqarnas ceiling of the Palatina Chapel in Palermo
2018
St. Peter’s Basilica inside the Royal Palace of Palermo, known as the Palatina Chapel, is one of the most popular medieval monuments in Sicily. Built between 1130 and 1163, it contains interesting wooden framings that represent both bearing and finishing structures. Studies about the Arab-Norman church have often concentrated on the very rich and suggestive decorative mosaic apparatus of walls and floorings, as well as the pictorial cycle of wooden ceilings. Knowledge about the constructive techniques adopted and, in particular, about the realization of the coverings, is very limited: there are wooden floors built at different levels, vaults and wooden ceilings and among these is the portio…