Search results for "HAP"
showing 10 items of 2767 documents
ASE narrow‐band noise pulsing in erbium‐doped fiber amplifier and its effect on self‐phase modulation
2019
In this paper, we report a study of the features of polarized and unpolarized narrow-band amplified spontaneous emission (ASE) in a low-doped erbium fiber at 976-nm pumping. We demonstrate that ASE noise can be treated as a train of Gaussian-like pulses with random magnitudes, widths, and inter-pulse intervals. ASE noise can also provide a statistical analysis of these three parameters. We also present the data that reveal ASE noise’s role in optical spectrum broadening through self-phase modulation of light propagating in a communication fiber. In particular, the data show that the ASE noise derivative defines the broadening’s spectral shape.
Beneficial impact of wave-breaking for coherent continuum formation in normally dispersive nonlinear fibers
2008
International audience; We study the evolution of a pulse propagating in a normally dispersive fiber in the presence of Kerr nonlinearity. We review the temporal and spectral impact of optical wave-breaking in the development of a continuum. The impact of linear losses or gain is also investigated.
Development of immunoaffinity columns for pyraclostrobin extraction from fruit juices and analysis by liquid chromatography with UV detection
2010
Abstract Pyraclostrobin belongs to a new generation of fungicides widely used to preserve high valuable crops. In the present study, three monoclonal antibodies with different affinities to this modern strobilurin have been evaluated for their usefulness in the production of immunoaffinity columns suitable for the solid-phase extraction, concentration, and clean-up of residues from food commodities. Different immunosorbents were produced and characterized in terms of antibody immobilization efficiency, immunosorbent binding capacity, optimum elution conditions, and reusability. Covalent coupling of the antibodies to Sepharose–CNBr gel took place with high yield (over 90%), whereas the immun…
Mepanipyrim haptens and antibodies with nanomolar affinity
2013
Mepanipyrim is an anilinopyrimidine fungicide used worldwide for crop protection. With the aim of developing useful immunoreagents for mepanipyrim immunoanalysis, two new functionalized derivatives were prepared and antibodies were generated. Affinity and specificity were assessed by direct and indirect competitive ELISA using homologous and heterologous conjugates. Although all antibodies were selective for the target analyte, the immunizing hapten structure was revealed as a determinant for high-affinity antibody production (IC50 = 3 nM). © 2013 The Royal Society of Chemistry.
Ready Access to Proquinazid Haptens via Cross-Coupling Chemistry for Antibody Generation and Immunoassay Development.
2015
17 pages, 4 tables, 5 figures.-- Publisher's PDF
Exploring alternative hapten tethering sites for high-affinity anti-picoxystrobin antibody generation
2011
The relevance of the linker tethering site in haptens was investigated for antibody generation and immunoassay development. Three derivatives of the strobilurin fungicide picoxystrobin were synthesized with the same functionalized spacer arm located at three different positions. Protein conjugates of those haptens were employed as immunogens, and novel polyclonal antibodies were produced and characterized. All haptens afforded highly specific antibodies, but different affinities to the free analyte were observed among the obtained antisera. Next, competitive enzyme-linked immunosorbent assays were studied in several formats, and site heterology was confirmed as an effective strategy for det…
Carbon nanotube-protein carriers enhance size-dependent self-adjuvant antibody response to haptens
2013
Carbon nanotubes (CNTs) are nanomaterials with interesting emerging applications. Their properties make CNTs excellent candidates for use as new nanovehicles in drug delivery, immunization and diagnostics. In the current study, we assessed the immune-response-amplifying properties of CNTs to haptens by using azoxystrobin, the first developed strobilurin fungicide, asamodel analyte. Anazoxystrobin derivative bearingacarboxylated spacer arm (hapten AZc6) was covalently coupled to bovine serum albumin (BSA), and the resulting BSA-AZc6 conjugate was covalently linked to four functionalized CNTs of different shapes and sizes, varying in diameter and length. These four types of CNT-based construc…
‘Early Neolithic’ graves of the Carpathian Basin are in fact 6000 years younger—Appeal for real interdisciplinarity between archaeology and ancient D…
2012
‘Early Neolithic’ graves of the Carpathian Basin are in fact 6000 years younger—Appeal for real interdisciplinarity between archaeology and ancient DNA research
Changes in Body Composition in Anorexia Nervosa : Predictors of Recovery and Treatment Outcome
2015
The restoration of body composition (BC) parameters is considered to be one of the most important goals in the treatment of patients with anorexia nervosa (AN). However, little is known about differences between AN diagnostic subtypes [restricting (AN-R) and binge/purging (AN-BP)] and weekly changes in BC during refeeding treatment. Therefore, the main objectives of our study were twofold: 1) to assess the changes in BC throughout nutritional treatment in an AN sample and 2) to analyze predictors of BC changes during treatment, as well as predictors of treatment outcome. The whole sample comprised 261 participants [118 adult females with AN (70 AN-R vs. 48 AN-BP), and 143 healthy controls].…
Electromagnetic Sensitivity Analysis and Shape Optimization Using Method of Moments and Automatic Differentiation
2009
Sensitivity analysis is an important part of gradient-based optimization of electromagnetic devices. We demonstrate how sensitivity analysis can be incorporated into an existing in-house method of moments solver with a relatively small amount of labor by using a technique called automatic differentiation (AD). This approach enables us to obtain (geometrical) sensitivities of the discrete solution with accuracy up to numerical precision. We compare the assembly time and memory usage of the modified and original solvers. Moreover, we optimize the shape of a dipole antenna and the dimensions of a Yagi-Uda array using the presented AD technique, traditional response level finite difference sens…