Search results for "HAp"
showing 10 items of 2767 documents
Chronic cocaine exposure impairs progenitor proliferation but spares survival and maturation of neural precursors in adult rat dentate gyrus
2006
Recent observations indicate that drugs of abuse, including alcohol and opiates, impair adult neurogenesis in the hippocampus. We have studied in rats the impact of cocaine treatment (20 mg/kg, daily, i.p.) on cell proliferation, survival and maturation following short-term (8-day) and long-term (24-day) exposure. Using 5'-bromo-2-deoxyuridine (BrdU) and Ki-67 as mitotic markers at the end of the drug treatments, we found that both short- and long-term cocaine exposures significantly reduced cell proliferation in the dentate gyrus (DG) of the hippocampus. By labelling mitotic cells with BrdU pulses before or during the early stages of the drug treatment, we determined that long-term cocaine…
Association between Opioid Receptor mu 1 (OPRM1) Gene Polymorphisms and Tobacco and Alcohol Consumption in a Spanish Population.
2015
Evidence gained from animals and humans suggests that the encephalic opioid system might be involved in the development of drug addiction through its role in reward. Our aim is to assess the influence of genetic variations in the opioid receptor mu 1 on alcohol and tobacco consumption in a Spanish population. 763 unrelated individuals (465 women, 298 men) aged 18-85 years were recruited between October 2011 and April 2012. Participants were requested to answer a 35-item questionnaire on tobacco and alcohol consumption, as well as to complete the AUDIT and Fagerström tests. Individuals were genotyped for three polymorphisms in the opioid receptor mu 1 (OPRM1) gene, using a TaqMan® protocol. …
Species-dependent stereospecific serum protein binding of the oral anticoagulant drug phenprocoumon
1978
13 mammalian species are classified into 3 clearcut groups with respect to the stereospecific serum protein-binding of phenprocoumon: 2 groups showing opposed stereospecific binding characteristics and a 3rd group exhibiting no stereospecific binding. Structural differences in the albumin molecule account for these stereospecific differences in serum protein-binding.
Monoclonal antibodies with subnanomolar affinity to tenofovir for monitoring adherence to antiretroviral therapies: from hapten synthesis to prototyp…
2020
Approximately 32 million people have died of HIV infection since the beginning of the outbreak, and 38 million are currently infected. Among strategies adopted by the Joint United Nations Programme on HIV/AIDS to end the AIDS global epidemic, the treatment, diagnosis, and viral suppression of the infected subjects are considered crucial for HIV prevention and transmission. Although several antiretroviral (ARV) drugs are successfully used to manage HIV infection, their efficacy strictly relies on perfect adherence to the therapy, which is seldom achieved. Patient supervision, especially in HIV-endemic, low-resource settings, requires rapid, easy-to-use, and affordable analytical tools, such …
SHAPES secure cloud platform for healthcare solutions and services
2020
The SHAPES project is an ambitious endeavour that gathers stakeholders from across Europe to create, deploy and pilot at large-scale a EU-standardised open platform incorporating and integrating a broad range of solutions, including technological, organisational, clinical, educational and societal, to enable the ageing population of Europe to remain healthy, active and productive, as well as to maintain a high quality of life and sense of wellbeing for the longest time possible. Not only each digital solution will be ethical, legal and appropriate for users, but also the results will align with the full and ethically responsible end-to-end exploitation of the new functionalities empowered b…
Hapenkulutuksen ja reiden lihasaktiivisuuden välinen yhteys pyöräilyssä
2002
Pollari, Terhi. Hapenkulutuksen ja reiden lihasaktiivisuuden välinen yhteys pyöräilyssä. LFY.203 Johdatus omatoimiseen tutkimustyöhön —kurssin tutkielma. Liikuntabiologian laitos. Jyväskylän yliopisto. Hapenkulutuksen kasvun tietyssä harjoituksessa on monesti oletettu olevan yhteydessä lisääntyneeseen lihasaktiivisuuteen työskentelevissä lihaksissa. Vaikka täysin selvää näyttöä ei ole, uskotaan hapenkulutuksen kasvun johtuvan lisääntyneestä motoristen yksiköiden käyttöönotosta tai syttymistiheydestä tehokkaan harjoituksen aikana. Hapenkulutusta ja lihasaktiivisuutta on tutkittu polkupyöräilyssä kuormilla, jotka ovat laktaattikynnystason kummallakin puolella. Tiettävästi pyöräilyssä ei kuite…
Laser-assisted nuclear decay spectroscopy of Au-176,Au-177,Au-179
2021
ispartof: PHYSICAL REVIEW C vol:104 issue:2 status: published
Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region.
2014
Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10 -20) near CXCR5; 11q24.3 (rs4937362, p = 6.76 × 10 -11) near ETS1; 3q28 (rs6444305, p = 1.10 × 10 -10) in LPP; 18q21.33 (rs17749561, p = 8.28 × 10 -10) near BCL2; and 8q24.21 (rs13254990, p = 1.06 × 10 -8) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DRß1 multiallelic amino acids at p…
A geographical pattern ofAntirrhinum(Scrophulariaceae) speciation since the Pliocene based on plastid and nuclear DNA polymorphisms
2009
Aim To infer phylogenetic relationships among Antirrhinum species and to reconstruct the historical distribution of observed sequence polymorphism through estimates of haplotype clades and lineage divergence. Location Antirrhinum is distributed primarily throughout the western Mediterranean, with 22 of 25 species in the Iberian Peninsula. Methods Plastid (83 trnS-trnG and 83 trnK-matK) and nuclear (87 ITS) sequences were obtained from 96 individuals representing 24 of the 25 Antirrhinum species. Sequences were analysed using maximum parsimony, Bayesian inference and statistical parsimony networking. Molecular clock estimates were obtained for plastid trnK-matK sequences using the penalized …
An interesting association betweenNeosphaera coccolithomorphaandCeratolithus cristatus(Haptophyta)
1997
Phytoplankton studies in the North Atlantic have revealed coccoliths of Neosphaera coccolithomorpha and Ceratolithus cristatus occurring on the same cell. This may indicate that each of these species represents a stage of one coccolithophorid life cycle, in which each phase possesses a different heterococcolith type. However, definitive evidence for this is lacking.