Search results for "HEPA"
showing 10 items of 5024 documents
A head start for life history development? Family income mediates associations between height and immune response in men.
2018
OBJECTIVES Male height and health affect a diverse range of social and economic outcomes such as competition for resources and mates. Life history theory predicts that limited availability of bioenergetic resources curbs the development of central life history functions such as somatic growth, immunity, and investment in offspring. Although genetic factors are important determinants of height, other factors such as income level may affect the incidence of infections during ontogeny, thus having indirect effects on somatic growth. We tested whether growing up in families with a higher income positively affects height and immune function. MATERIALS AND METHODS Seventy-three young Latvian men …
Lack of molluscan host diversity and the transmission of an emerging parasitic disease in Bolivia.
2001
Fasciolosis is a re-emerging parasitic disease that affects an increasing number of people in developing countries. The most severe endemic affects the Bolivian Altiplano, where the liver fluke (Fasciola hepatica) and its hermaphroditic snail host, Lymnaea truncatula, have been introduced from Europe. To achieve a better understanding of the epidemiological situation and the consequences of the colonization event of this invasive species, genetic analysis of Bolivian snail populations was needed. Here we compare the genetic diversity and population structure of snail samples from the Bolivian Altiplano with samples from the Old World at six polymorphic microsatellite loci. Whereas some vari…
Assessing the importance of nursery areas of European hake (Merluccius merluccius) using a body condition index
2017
Abstract In this study, we analysed the variability of reserve storage in juvenile European hake (Merluccius merluccius) off the western coasts of Italy (Central Mediterranean Sea). Reserve storage was measured by the hepatosomatic index (HSI), in relation to environmental and population covariates. HSI has been proved to be a consistent measure of energy storage in gadoids, thus reflecting quantity and quality of food availability for growth. Generalized Additive Models for Location, Scale and Shape (GAMLSS) were used to model the effect of depth, bottom temperature, bottom currents, fish density and fish body size on HSI of juvenile European hake. The results revealed that reserve storage…
Occurrence of the LiverwortPallavicinia lyelliiin Poland
2018
Stebel, A., Fojcik, B., Rosadzinski, S. & Wierzcholska, S. 2018. Occurrence of the liverwort Pallavicinia lyellii in Poland. – Herzogia 31: 26–36.Pallavicinia lyellii, a liverwort species threatened in Europe, is a rare component of the bryoflora in Poland. This paper presents information on its 27 published and new sites, a brief discussion about ecology and threats, as well as a map of its current distribution in Poland.
Self-assembled multivalent (SAMul) ligand systems with enhanced stability in the presence of human serum
2019
Self-assembled cationic micelles are an attractive platform for binding biologically-relevant polyanions such as heparin. This has potential applications in coagulation control, where a synthetic heparin rescue agent could be a useful replacement for protamine, which is in current clinical use. However, micelles can have low stability in human serum and unacceptable toxicity profiles. This paper reports the optimi- sation of self-assembled multivalent (SAMul) arrays of amphiphilic ligands to bind heparin in competitive conditions. Specifically, modification of the hydrophobic unit kinetically stabilises the self-assembled nanostructures, preventing loss of binding ability in the presence of…
Detección sistemática del cáncer colorrectal
2019
El cancer colorrectal, uno de los principales problemas de salud publica, cumple con las condiciones para la deteccion en la poblacion general. Los resultados disponibles muestran que una prueba de sangre oculta en heces puede reducir la mortalidad por cancer colorrectal. Por eso, la Comision Europea recomienda la realizacion de esta deteccion en las poblaciones de riesgo. En la actualidad, nuevas pruebas, las pruebas inmunologicas que permiten una lectura automatizada y cuantitativa, han sustituido a las pruebas de primera generacion, las pruebas del guayacol. Representan un gran avance: duplican la tasa de deteccion de canceres y multiplican por 3-4 la de los adenomas con alto riesgo de t…
Auto-transplantation hépatique après résection ex-vivo pour échinococcose alvéolaire au stade terminal
2019
Resume La resection complete des lesions, associee a un traitement par albendazole pendant deux ans representent le traitement le plus efficace de l’echinococcose alveolaire hepatique (EAH). Seulement un petit nombre de patients peuvent beneficier d’une hepatectomie conventionnelle du fait de l’infiltration extensive des lesions hepatiques d’EAH et pour les autres patients un traitement par albendazole avec ou sans allotransplantation ou un traitement interventionnel non chirurgical doivent etre envisages. Bien que la transplantation soit consideree comme une option legitime pour des cas aussi avances, la penurie de donneurs d’organes, la necessite d’un traitement immunosuppresseur postoper…
Investigación clínica en 2016: artículos destacados
2017
Resumen En el ano 2016, se han publicado numerosos articulos de calidad sobre la enfermedad de Crohn (EC) y la colitis ulcerosa (CU). La importancia de la dieta o de los germenes en la enfermedad inflamatoria intestinal (EII), la repercusion de la EII en la calidad de vida, el papel de la calprotectina o la posibilidad de usar el PET en el seguimiento de la EII son algunos de los temas a destacar. El tratamiento ha sido foco de numerosos ensayos, consolidando el infliximab (sugiriendo niveles en la semana 2), el adalimumab y el golimumab, como tratamientos de primera linea, apoyando el uso de ustekinumab en EC, y dejando el metotrexato como ultimo recurso en la CU, salvo en artropatia. Por …
Manejo práctico de la intensificación del tratamiento biológico en los pacientes con enfermedad inflamatoria intestinal
2016
Resumen El tratamiento biologico con anticuerpos frente al factor de necrosis tumoral alfa (anti-TNF) ha mejorado las posibilidades terapeuticas de la enfermedad inflamatoria intestinal (EII). Estos farmacos han mostrado una elevada eficacia clinica, asociada fundamentalmente a la curacion de la mucosa intestinal y a la mejora de la calidad de vida de los pacientes. Sin embargo, un porcentaje considerable de pacientes no responden inicialmente al tratamiento o pierden la respuesta conseguida a lo largo del tiempo. Con vistas a resolver el fracaso del tratamiento anti-TNF, se han empleado varias estrategias en una actitud conocida como intensificacion del tratamiento. Estas estrategias inclu…