Search results for "Himera"
showing 10 items of 79 documents
Reconstruction of the evolutionary history of Saccharomyces cerevisiae x S. kudriavzevii hybrids based on multilocus sequence analysis.
2012
In recent years, interspecific hybridization and introgression are increasingly recognized as significant events in the evolution of Saccharomyces yeasts. These mechanisms have probably been involved in the origin of novel yeast genotypes and phenotypes, which in due course were to colonize and predominate in the new fermentative environments created by human manipulation. The particular conditions in which hybrids arose are still unknown, as well as the number of possible hybridization events that generated the whole set of natural hybrids described in the literature during recent years. In this study, we could infer at least six different hybridization events that originated a set of 26 S…
Enhancing production and cytotoxic activity of polymeric soluble FasL-based chimeric proteins by concomitant expression of soluble FasL.
2012
International audience; Membrane FasL is the natural trigger of Fas-mediated apoptosis. A soluble homotrimeric counterpart (sFasL) also exists which is very weakly active, and needs oligomerization beyond its trimeric state to induce apoptosis. We recently generated a soluble FasL chimera by fusing the immunoglobulin-like domain of the leukemia inhibitory factor receptor gp190 to the extracellular region of human FasL, which enabled spontaneous dodecameric homotypic polymerization of FasL. This polymeric soluble human FasL (pFasL) displayed anti-tumoral activity in vitro and in vivo without systemic cytotoxicity in mouse. In the present work, we focused on the improvement of pFasL, with two…
Genomic instability in an interspecific hybrid of the genus Saccharomyces: a matter of adaptability
2020
Ancient events of polyploidy have been linked to huge evolutionary leaps in the tree of life, while increasing evidence shows that newly established polyploids have adaptive advantages in certain stress conditions compared to their relatives with a lower ploidy. The genus Saccharomyces is a good model for studying such events, as it contains an ancient whole-genome duplication event and many sequenced Saccharomyces cerevisiae are, evolutionary speaking, newly formed polyploids. Many polyploids have unstable genomes and go through large genome erosions; however, it is still unknown what mechanisms govern this reduction. Here, we sequenced and studied the natural S. cerevisiae × Saccharomyces…
Geophysical investigations at the Himera archaeological site, northern Sicily
2007
In this paper we present a geophysical survey that was carried out as a research activity during field trips to the Himera archaeological site, where relics of a large Greek settlement are still buried, effected by a joint group of archaeologists and geophysicists during an educational project. Two-dimensional (2D) resistivity and ground-penetrating radar (GPR) surveys were performed to locate buried archaeological structures at this archaeological site. The results of the GPR surveys show some anomalies characterized by semi-hyperbolic shapes. In some restricted areas of the town, two grids of parallel GPR profiles were acquired while time- and depth-slices were calculated to identify the …
Molecular and enological characterization of a natural Saccharomyces uvarum and Saccharomyces cerevisiae hybrid
2015
Available online 17 March 2015
Role of mTOR inhibitors for the control of viral infection in solid organ transplant recipients
2016
Appropriate post-transplant immunosuppressive regimens that avoid acute rejection, while reducing risk of viral reactivation, have been sought, but remain a chimera. Recent evidence suggesting potential regulatory and antiviral effects of mammalian target of rapamycin inhibitors (mTORi) is of great interest. Although the concept of an immunosuppressive drug with antiviral properties is not new, little effort has been made to put the evidence together to assess the management of immunosuppressive therapy in the presence of a viral infection. This review was developed to gather the evidence on antiviral activity of the mTORi against the viruses that most commonly reactivate in adult solid org…
Evolution of gynoecium morphology in Old World Papaveroideae: a combined phylogenetic/ontogenetic approach.
2011
PREMISE OF THE STUDY: The correct assessment of homology is an important prerequisite for reconstructing phylogenetic relationships and character evolution. Old World Papaveroideae (Papaver, Meconopsis, Roemeria, Stylomecon) show substantial diversity in gynoecium and capsule morphology. In particular, capsules can have distinct styles (Meconopsis p.p., Stylomecon) or a sessile stigmatic disc (Papaver). Molecular phylogenetic analyses of Old World Papaveroideae had shown that neither taxa with styles nor those with stigmatic discs represent monophyletic lineages. We here investigate whether either styles or stigmatic discs have arisen repeatedly during the diversification of Old World Papav…
La battaglia di Himera nelle Storie di Erodoto e il sincronismo con Salamina
2022
The very short report of the battle of Himera given by Herodotus’ Histories seems to have the primary aim of supporting a widespread tradition among the inhabitants of Sicily (still circulating at the time when the historian lived) about the true reason preventing Gelon from siding with the Hellenic League against Persians: he was impelled to engage in the battle of Himera, which took place the very same day as the sea battle of Salamis. No celebratory intent emerges from the account of Gelon’s and Theron’s victory over the Carthaginians, since Herodotus wants to report all the versions known to him about the explanations given to Gelon’s refusal to join the Hellenic League; there is no roo…
Himera. Casa VI5: un tentativo di analisi funzionale
2013
The Author proposes, while emphasizing the difficulty of reinterpreting an old excavation, a functional analysis of a Himerean house which has been excavated in 1972. Noting that at Himera there is not a typical house plan, he begins with the description of structures and materials from House VI 5 and proposes a sociological and economical interpretation of their domestic use. House VI 5 is one of the largest houses in the city in the fifth century B.C. consisting of three parts (one for storage, a public place, and a private one) and attests that Himereans knew and used new domestic patterns from metropolitan Greece, in particular in Athens, and were actively involved in spreading cultural…
Cinquant’anni di ricerche e prospezioni nella chora imerese. Bilanci e prospettive
2018
The aim of this paper is to make a critical review of the archaeological research (excavation and survey) in the hinterland of Himera, from the beginning of the last century to the present time. The research is focused on: identifying the geographical and morphological characters, and the resources of the territory in Antiquity; analysing the distribution of the settlements from the Greek to the Medioeval times, both connected to the resources and to the various aspects of the landscape. Finally, the modern and contemporary activities, such as the agricultural use of the territory.