Search results for "Histamine"

Generation of an Eosinophilotactic Factor from Human PMNs by Various Mechanisms of Cell Activation

1979

It is well established that an increase in the number of eosinophils both in tissue and in the circulation is a feature of many clinical conditions based on delayed (1,2) and immediate type hypersensitivity reactions (3,4). Since eosinophils have been recognised to exert specific killer function on parasites (5) and to be prominent participants at sites of inflammation, the mechanisms of their chemo-attraction are of major importance. In immediate type hypersensitivity reactions, eosinophils have been demonstrated to counteract the mediators of inflammation such as histamine (6), the SRS-A (7) and the platelet aggregating factor (8).

Sedation in allergic rhinitis is caused by the condition and not by antihistamine treatment

1996

Sedation is regarded as a common side-effect of most H1-antihistamines. This view must be accepted, yet can hardly be assessed under treatment of allergic disorders. Since central sedative potency is hard to evaluate, different methods of measurement have been introduced in the four phases of clinical investigation. While tests of high complexity in early trials can detect true central effects, they seem to have the disadvantage of not taking into consideration the important interactions of drugs with the disorder. Therefore, we used a visual analog scale (VAS) as an instrument to demonstrate sedative effects in five clinical studies carried out between 1989 and 1994 with a total number of …

Struktur-Wirkungsbeziehungen bei Histaminanaloga, 14. Mitt. 4-Aminomethyl-benzimidazole und 9-Amino-naphth[1,2-d]imidazole

1977

Es wird die Darstellung der bicyclischen Histaminanaloga 4-Aminomethyl-benzimidazol (3a) und 4-Aminomethyl-4,5,6,7-tetrahydro-benzimidazol (3b) sowie der tricyclischen Analoga 9-Amino-6,7,8,9-tetrahydro-naphth[1,2-d]imidazol (6b) und 9-Amino-4,5,5a,6,7,8,9,9a-octahydro-naphth[1,2-d]imidazol (6c) beschrieben. 4-(Aminomethyl)benzimidazoles and 9-Aminonaphth[1,2-d]imidazoles Syntheses of the bicyclic histamine analogues 4-(aminomethyl)benzimidazole (3a) and 4-aminomethyl-4,5,6,7-tetrahydrobenzimidazole (3b) and of the tricyclic analogues 9-amino-6,7,8,9-tetrahydronaphth[1,2-d]imidazole (6b) and 9-amino-4,5,5a,6,7,8,9,9a-octahydronaphth[1,2-d]-imidazole (6c) are described.

243 HISTAMINE-IONTOPHORESIS FOR DIFFERENTIATION OF C-FIBRE FUNCTION IN POST-HERPETIC NEURALGIAS

2007

Struktur-Wirkungs-Beziehungen bei Histaminanaloga, 7. Mitt. Pyridyl- und Piperidyl-histamine

1975

Es wurden die drei isomeren 2-substituierten Piperidyl-(7) und Pyridyl-histamine (6) aus den entsprechenden 2-substituierten 4-Hydroxymethyl-imidazolen (8) oder 4-(2-Hydroxy-athyl)-imidazolen (3) auf 2 verschiedenen Wegen dargestellt und auf ihre histaminartige Wirksamkeit untersucht. Pyridyl- and Piperidyl-histamines The three 2-substituted histamine isomers of piperidyl-(7) as well as pyridyl-histamines (6) were synthesized from the corresponding 2-substituted 4-hydroxymethyl-imidazoles (8) or 4-(2-hydroxyethyl)-imidazoles (3) by two different ways and tested for their histamine-like activity.

2(S)-Amino-3-[1H-imidazol-4(5)-yl]propyl cyclohexylmethyl ether dihydrochloride and 2(S)-amino-3-[1H-imidazol-4(5)-yl]propyl 4-bromobenzyl ether dihy…

2000

(Cyclohexylmethyloxymethyl)(1H-imidazol-4-iomethyl)-(S)-ammonium dichloride, C(13)H(25)N(3)O(+).2Cl(-), and (4-bromobenzyl)(1H-imidazol-4-iomethyl)-(S)-ammonium dichloride, C(13)H(18)BrN(3)O(+).2Cl(-), are model compounds with different biological activities for evaluation of the histamine H3-receptor activation mechanism. Both title compounds occur in almost similar extended conformations.

Histaminähnliche Verbindungen mit cyclisierter Seitenkette 1. Mitt. über Struktur-Wirkungs-Beziehungen bei Histaminanaloga

1973

Als potentiell histaminartig wirksame Substanzen wurden 4-substituierte Piperidyl- und Aminocyclohexyl-imidazole dargestellt. Von diesen erwiesen sich 4-(3-Piperidyl)-imidazol (4b) und 4-(2-Aminocyclohexyl)-imidazol (8a) als histaminomimetisch wirksam. Uber Struktur-Wirkungs-Beziehungen der Histaminanaloga mit cyclisierter Seitenkette des Histaminmolekuls wird be richtet. Histamine-like Compounds with Cyclized Side Chain As substances with possible histamine-like activity 4-substituted piperidyl- and aminocyclohexyl-imidazoles were prepared. Two of them, 4-(3-piperidyl)-imidazole (4b) and 4-(2-aminocyclohexyl)-imidazole (8a), have histamine-like activity. Structure-action relationships of h…

H2-Antihistaminika, 25. Mitt. Synthese und H2-antagonistische Wirkung monosubstituierter 1,2,4-Oxadiazol-3,5-diamine

1985

Es wurden die N3- bzw. N5-substituierten 1,2,4-Oxadiazol-3,5-diamine 4a-e und 5a-e dargestellt und auf Histamin-H2-antagonistische Aktivitat untersucht. H2-Antihistaminics, XXV: Synthesis and H2-Antagonistic Activity of Monosubstituted 1,2,4-Oxadiazole-3,5-diamines The N3-or N5-substituted 1,2,4-Oxadiazole-3,5-diamines 4a-e and 5a-e were prepared and tested for histamine H2-antagonistic activity.

Acetylcholine At Motor Nerves: Storage, Release, and Presynaptic Modulati On By Autoreceptors and Adrenoceptors

1992

Publisher Summary This chapter focuses on the modulation of acetylcholine release from the motor endplate by presynaptic receptors. An individual neuron can regulate its function, the release of transmitters or modulators, through the activation of local feedback loops. After escaping the neuronal membrane and entering the synaptic cleft (or extracellular space), the transmitter activates both the receptors localized at the endorgan (postsynaptic receptors) and the receptors localized at the nerve terminal within its diffusion radius (so-called presynaptic or neuronal receptors). Stimulation of presynaptic receptors triggers the generation of intracellular signals that modify ion channels o…

Struktur-Wirkungs-Beziehungen bei Histaminanaloga, 21. Mitt. Synthese und Wirkung Nα-substituierter Histamine

1980

Es wurden Nα-substituierte Histamine dargestellt und auf ihre agonistische Wirkung an Histamin H1- und H2-Rezeptoren untersucht. Structure-Activity Relationships of Histamine Analogues, XXI: Synthesis and Pharmacology of Nα-Substituted Histamines Nα-Substituted histamines were synthesized and investigated with regard to their agonistic activity at histamine H1 and H2 receptors.