Search results for "I.5"
showing 10 items of 399 documents
Dysidotronic acid, a new and selective human phospholipase A2 inhibitor from the sponge Dysidea sp.
2000
Abstract A new bioactive sesquiterpenoid, named dysidotronic acid 1, with a rearranged drimane skeleton has been isolated from the sponge Dysidea sp. from Vanuatu islands, along with bolinaquinone 2. The chemical structure of 1 was determined on the basis of spectroscopic data. Dysidotronic acid significantly inhibited human synovial phospholipase A2 (PLA2) at 10 μM, with an IC50 value of 2.6 μM and a higher selectivity and potency towards this enzyme than the reference inhibitor manoalide.
ChemInform Abstract: Synthesis and Antiproliferative Activity of Novel 3-(Indazol-3-yl)-quinazolin-4(3H)-one and 3-(Indazol-3-yl)-benzotriazin-4(3H)-…
2010
Several new 3-(indazol-3-yl)-quinazolin-4(3H)-one and 3-(indazol-3-yl)-benzotriazin-4(3H)-one derivatives 5 and 6 were synthesized and tested for their in vitro antiproliferative activity against Raji, K562, and K562-R cell lines. The pharmacological screening showed that some 2, 6, or 7-substituted quinazolinones 5 posses a significant antiproliferative activity, with a percentage growth inhibition ranging from 44.8% to 100% at 50 microM, which was higher than that showed by the unsubstituted derivative 5a previously synthesized. For the most active compounds 5d, 5f, and 5g the IC50 were recorded.
ChemInform Abstract: Synthesis of New 3-(3-Phenyl-isoxazol-5-yl) or 3-[(3-Phenyl-isoxazol-5-yl)amino] Substituted 4(3H)-Quinazolinone Derivatives wit…
2010
A novel series of 3-(3-phenyl-isoxazol-5-yl) or 3-[(3-phenyl-isoxazol-5-yl)amino] substituted 4(3H)-quinazolinone derivatives was synthesized. The compounds were tested for their antineoplastic activity in vitro against Raji (human Burkitt limphoma). K-562 (human chronic myelogeneous leukemia) and U937 (human histiocytic limphoma) cell lines. The most active quinazolinones showed IC50 values in the range 16-30 microM.
Embryonic development of corkwing wrasse, Symphodus melops
2016
Master's thesis Aquatic Ecology BIO500 - University of Agder 2016 Eggs from corkwing wrasse, Symphodus melops were described, photographed and illustrated to characterise the embryonic development of this species. Egg development was divided into 8 stages from fertilisation until hatching with descriptions of key features for each stage. The rate of development in corkwing wrasse eggs at temperatures commonly found along the Norwegian coast (12, 15 and 18 C) was also investigated. The rate of development was faster at higher temperatures. Keywords: labridae, cleaner fish, embryonic development, corkwing wrasse
Embodied graffiti and street art research
2021
Graffiti and street art research (GSAR) has become more acknowledged within the academic discourse; however, it has much to gain from theorising its methodological aspects. As a multidisciplinary field, GSAR has mostly used qualitative research methods, exploring urban space through methods that range from visual recordings to ethnography, emphasising the researchers’ reflexivity. This qualitative approach has, however, paid little attention to the role of embodied practices. In this paper we discuss how embodied methodologies provide multisensory research results where the experienced moments, the participant’s and researcher’s senses, cognition and mobility in urban spaces are connected.…
The Impact of Smart City Initiatives on Human Rights : A Qualitative Research Study
2019
Master's thesis Information Systems IS501 - University of Agder 2019 Context:A smart city is a concept where municipalities use ICTto increase efficiency, sustainability and quality of life forits citizensand city operations. Smart city initiatives useIoT technologies, enabled by ICTs to gather large volumesof unstructured data,known as BigData.The aim of any smart city initiativeisto increase thequality of lifein acity, but posesa threat tocitizens privacy, security andfreedom of expressiondue to the large volumes of databeing collected in smart cities,potentially violatingfundamental rightsin theUniversal Declaration of Human Rights.Purpose:This thesis investigatesthe connection between s…
Gadskārtu ieražu svinēšana, kā līdzeklis 5-6 gadus vecu bērnu attīstības sekmēšanai
2019
Indras Lorences kvalifikācijas darba tēma pirmsskolas pedagoģijā ir „Gadskārtu ieražu svinēšana, kā līdzeklis 5-6 gadus vecu bērnu attīstības sekmēšanai”. Pētījuma mērķis ir izpētīt gadskārtu ieražu svētku svinēšanas ietekmi uz 5-6 gadus vecu bērnu attīstību un izstrādāt plānojumu 5-6 gadus vecu bērnu attīstības sekmēšanai atbilstoši pirmsskolas izglītības vadlīnijās noteiktajam, integrējot gadskārtu ieražu svētku svinēšanu pirmsskolas pedagoģiskajā procesā. Darba pirmajā un otrajā nodaļā tiek analizēta literatūra un informācijas avoti par gadskārtu ieražu svinēšanu un tradīcijām, kā arī 5-6 gadus vecu bērnu attīstība. Trešajā daļā, balstoties uz abu iepriekšējo nodaļu secinājumiem, kā arī …
Cytotoxic effects of individual and combined sterigmatocystin and nivalenol on liver hepatocellular carcinoma cells
2020
Abstract Since humans are exposed to different mycotoxins through daily intake, there is increasing concern about the adverse effects of the interactions between them. Cytotoxicity of sterigmatocystin (STE) and nivalenol (NIV) alone and in combination in human hepatocarcinoma (HepG2) cells was evaluated by MTT assay. Furthermore, ROS production and alteration of ΔΨm as mechanisms of action were assessed. Cells were treated with concentrations ranging from 0.15 to 5 μM for NIV and from 0.78 to 50 μM for STE individually and in binary combinations. The combination ratio between the mixture STE + NIV was 10:1. The IC50 values of NIV ranged from 0.96 to 0.66 μM, whereas no IC50 values were obta…
Energy efficiency in wireless networks
2013
Tämä pro gradu -työ on sekundääritutkimuksena tehty kirjallisuuskatsaus energiatehokkuuden tarkastelusta langattomissa verkoissa. Työssä tarkastellaan erilaisia mobiiliverkkojen energiansäästömahdollisuuksia. Pääpaino työssä on suunnattu erityisesti 3G ja LTE -verkkoihin, kuitenkin eksoottisempiakaan verkkoja unohtamatta. Työ alkaa erilaisten mobiiliverkkojen energiansäästösyiden ja tutkimusmotivaattoreiden tunnistamisella ja jatkuu langattomien verkkojen energian kulutuksen jaotuksella, sekä erilaisten energiansäästömahdollisuuksien vertailuilla. Työn empiirisessä osassa nostetaan lisäksi esille lyhyt Octave-simulaatio kollaboroivan mobiilipilven noodien energiansa…
Synthesis and Antiproliferative Activity of 2,5-bis(3′-Indolyl)pyrroles, Analogues of the Marine Alkaloid Nortopsentin
2013
2,5-bis(3′-Indolyl)pyrroles, analogues of the marine alkaloid nortopsentin, were conveniently prepared through a three step procedure in good overall yields. Derivatives 1a and 1b exhibited concentration-dependent antitumor activity towards a panel of 42 human tumor cell lines with mean IC50 values of 1.54 μM and 0.67 μM, respectively. Investigating human tumor xenografts in an ex-vivo clonogenic assay revealed selective antitumor activity, whereas sensitive tumor models were scattered among various tumor histotypes.