Search results for "IBA"

Impiego dell'atosiban nella minaccia di parto prematuro

2006

È stato condotto uno studio prospettico su 66 gravide con lo scopo di vlutare l'efficacia e la sicurezza dell'atosiban nel trattamento della minaccia di parto pretermine. L'efficacia tocolitica è stata valutata in termini di numero di donne che non hanno parrorito dopo 48 ore e dopo 7 giorni dall'inizio della terapia. La sicurezza del farmaco, invece, in termini di effetti collaterali materni e morbilità neonatale. Le pazienti che presentavano contrazioni uterine intense e persistenti (3 ogni 10 minuti) sono state suddivise in base alle modificazioni del collo in 3 gruppi. Il 1 gruppo è composto da 20 gravide con lunghezza del collo compresa tra 25-35 mm, il II gruppo è composto da 30 gravi…

Combining in the melt physical and biological properties of poly(caprolactone) and chlorhexidine to obtain antimicrobial surgical monofilaments.

2012

Bacterial infections on a sutured wound represent a critical problem, and the preparation of suture threads possessing antimicrobial properties is valuable. In this work, poly(caprolactone) (PCL) monofilaments were compounded at the concentration of 1, 2 and 4 % (w/w), respectively, to the antiseptic chlorhexidine diacetate (CHX). The incorporation was carried out in the melt by a single-step methodology, i.e. “online” approach. Mechanical tests revealed that the incorporation of CHX does not significantly change tensile properties of PCL fibres as the thermal profile adopted to prepare the compounded fibres does not compromise the antibacterial activity of CHX. In fact, CHX confers to comp…

Thibaut in Italien und ins Italienische. Erste Schritte zu einer Forschungsperspektive

2017

Reconsidering the accuracy of X-ray fluorescence and ion beam based methods when used to measure the thickness of ancient gildings

2017

Since at least 5000 years ago, gilding techniques have been used for decoration purposes or to make artefacts appear as made of solid gold. Investigation of ancient gildings inevitably requires measuring their thickness, which is usually done either through the observation of cross-sections or by methods such as Rutherford backscattering spectroscopy, particle-induced X-ray emission and X-ray fluorescence. Whereas the former method requires sampling, the latter ones are non-invasive and therefore preferable. These non-invasive methods, however, measure the number of atoms per unit area, which can be converted into thickness only if the density is known. So far this has not been considered a…

Assessment of the antioxidant and antibacterial activities of different olive processing wastewaters.

2017

Olive processing wastewaters (OPW), namely olive mill wastewater (OMW) and table-olive wastewaters (TOW) were evaluated for their antibacterial activity against five Gram-positive and two Gram-negative bacteria using the standard disc diffusion and thin layer chromatography (TLC)-bioautography assays. Disc diffusion screening and bioautography of OMW were compared to the phenolic extracts of table-olive brines. Positive activity against S. aureus was demonstrated. The optimization of chromatographic separation revealed that hexane/acetone in the ratio of 4:6 was the most effective for phenolic compounds separation. A HPLC-MS analysis was performed showing that only two compounds, hydroxytyr…

Unveiling distribution patterns of freshwater phytoplankton by a next generation sequencing based approach.

2012

The recognition and discrimination of phytoplankton species is one of the foundations of freshwater biodiversity research and environmental monitoring. This step is frequently a bottleneck in the analytical chain from sampling to data analysis and subsequent environmental status evaluation. Here we present phytoplankton diversity data from 49 lakes including three seasonal surveys assessed by next generation sequencing (NGS) of 16S ribosomal RNA chloroplast and cyanobacterial gene amplicons and also compare part of these datasets with identification based on morphology. Direct comparison of NGS to microscopic data from three time-series showed that NGS was able to capture the seasonality in…

Management of HCV-Related Liver Disease in Hemophilia and Thalassemia

2018

AbstractChronic infection with the hepatitis C virus (HCV) has long been the dominant complication of substitution therapy in patients with inherited blood disorders and the cause of anticipated death due to end-stage liver disease. In hemophilia, transmission of HCV with clotting factors concentrates started to be curbed in the mid-1980s following the adoption of procedures of virus inactivation of concentrates based on heat, whereas in the 1990s treatment of HCV infection with interferon monotherapy was attempted, however, with little success. The advent of combination therapy of interferon with ribavirin led to a substantial improvement of treatment outcome (40% rate of cure), that howev…

Boceprevir is highly effective in treatment-experienced hepatitis C virus-positive genotype-1 menopausal women

2014

AIM: To investigate the safety/efficacy of Boceprevirbased triple therapy in hepatitis C virus (HCV)-G1 menopausal women who were historic relapsers, partial-responders and null-responders. METHODS: In this single-assignment, unblinded study, we treated fifty-six menopausal women with HCV-G1, 46% F3-F4, and previous PEG-α/RBV failure (7% null, 41% non-responder, and 52% relapser) with 4 wk lead-in with PEG-IFNα2b/RBV followed by PEGIFNα2b/RBV+Boceprevir for 32 wk, with an additional 12 wk of PEG-IFN-α-2b/RBV if patients were HCV-RNA-positive by week 8. In previous null-responders, 44 wk of triple therapy was used. The primary objective of retreatment was to verify whether a sustained virolo…

Interaction of an odorant lactone with model phospholipid bilayers and its strong fluidizing action in yeast membrane

2003

International audience; Some odorant lactones are naturally present in fruits or in fermented products; they can also be used as food additives and can be produced by microorganisms at the industrial scale by biotechnological processes. Gamma-decalactone was previously shown to have antimicrobial properties. We determined by infrared spectroscopy measurements that this compound rapidly diffused into model phospholipid bilayers (within 2 min), modifying the general physical state of a dimyristoyl-L-alpha-phosphatidylcholine (DMPC) film. In vivo, the lactone strongly increased membrane fluidity in the model yeast Yarrowia lipolytica, as evaluated by fluorescence anisotropy measurements. This …

L’«archivio della memoria» tra 'biografia' e ‘diario’

2018

Donatella La Monaca si inoltra nell’intrinseco rapporto tra la scrittura epistolare, saggistica ed inventiva di Tomasi di Lampedusa soffermandosi sulle modalità con cui l’invenzione e il ricordo si fondono nell’azione trasfigurante della memoria, nel suo valore cognitivo e poetico. Ci si spinge da ultimo a ricostruire i termini di un dibattito sul caso Gattopardo di cui si pongono in risalto alcuni snodi cruciali tra cui quello, che, proprio nel contesto di tale dibattito, approfondisce le fasi evolutive di un suo episodio nevralgico, ovvero la lettura, animata da tensioni etiche e civili, di Leonardo Sciascia,dall’iniziale diffidenza alla matura comprensione.Si compone così un itinerario c…