Search results for "ISR"

showing 10 items of 525 documents

Molecular Basis for Endocrine Disruption by Pesticides Targeting Aromatase and Estrogen Receptor

2020

The intensive use of pesticides has led to their increasing presence in water, soil, and agricultural products. Mounting evidence indicates that some pesticides may be endocrine disrupting chemicals (EDCs), being therefore harmful for the human health and the environment. In this study, three pesticides, glyphosate, thiacloprid, and imidacloprid, were tested for their ability to interfere with estrogen biosynthesis and/or signaling, to evaluate their potential action as EDCs. Among the tested compounds, only glyphosate inhibited aromatase activity (up to 30%) via a non-competitive inhibition or a mixed inhibition mechanism depending on the concentration applied. Then, the ability of the thr…

aromatasemedicine.drug_classHealth Toxicology and Mutagenesislcsh:MedicineEstrogen receptorMixed inhibitionEndocrine Disruptors010501 environmental sciencesPharmacology01 natural sciencesArticle03 medical and health scienceschemistry.chemical_compoundImidaclopridReceptorsmedicineHumansAromataseestrogenic activity030304 developmental biology0105 earth and related environmental sciences0303 health sciencesAromatase inhibitorendocrine disrupting chemicalbiologyAromatase Inhibitorslcsh:RPublic Health Environmental and Occupational HealthEstrogenspesticidesPesticideThiaclopridEstrogenmolecular dynamicsReceptors EstrogenchemistryEstrogenMELN allosteric inhibitionbiology.proteingene reporter assayAromatase; Endocrine disrupting chemical; Estrogen receptor; Estrogenic activity; Gene reporter assay; MELN allosteric inhibition; Molecular dynamics; Neonicotinoids; Pesticides; Aromatase; Aromatase Inhibitors; Estrogens; Humans; Receptors Estrogen; Endocrine Disruptors; Pesticidesneonicotinoidsestrogen receptorInternational Journal of Environmental Research and Public Health
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Il problema della legittima difesa nei confronti di milizie non statali alla luce dell'ultima crisi tra Israele e Libano

2007

attacchi armatiIUS/13 - DIRITTO INTERNAZIONALELibanoNazioni UniteLegittima difesaterrorismo Israele
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The Slow Adoption Rate of Software Robotics in Accounting and Payroll Services and the Role of Resistance to Change in Innovation-Decision Process

2022

Robotic process automation (RPA) has by now for years been viewed as a disruptive innovation that will have a significant impact on accounting, HR and payroll services, and yet the rate of adopting the innovation has not reached a level anticipated in past predictions. As several elements have a negative impact on the organization’s rate of adopting RPA, passive resistance to change has a significant impact in the form of constant dithering. Resistance to change can emerge at any stage of the Innovation-Decision process and fluctuate throughout the continued adoption, causing wasted investments, capabilities and resources. peerReviewed

automaatioresistance to changeautomaatiojärjestelmättaloushallintorobotithenkilöstöhallintotechnology adoptionDiffusion of Innovationmuutosvastarintadisruptive innovationkäyttöönottorobotic process automationinnovaatiot
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The mammalian geochronology and biogeography of Paşalar (Middle Miocene, Turkey)

1990

Abstract The Pasalar fauna includes 56 mammalian species of European. Asian, African and North American origin. Evidence provided on the stage-of-evolution of the primates Sivapithecus darwini and cf. Kenyapithecus, the rodent Turkomys pasalarensis, insectivores, carnivores, rhinos, suids and ruminants suggests that Pasalar is correlative with the Late Langhian marine stage and European Mammal Neogene Zone 6., circa 15 Ma (million years ago). A review of the Pasalar fauna's biogeographic history suggests that it was aggregated by a succession of pulsed intercontinental geographic extensions tied to global sea-level lowering events during the earlier half of the Miocene.

biologyEcologyBiogeographyFaunabiology.organism_classificationNeogenePaleontologyAnthropologyGeochronologyMammalMiddle Miocene disruptionKenyapithecusSivapithecusEcology Evolution Behavior and SystematicsGeologyJournal of Human Evolution
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Saproxylic beetle assemblages in the Mediterranean region:Impact of forest management on richness and structure

2010

Forests cover almost 30% of the Mediterranean region today, yet forest management activities have influenced structure and composition of both natural and planted forests. To date no study has been conducted to evaluate the impact of forest management on saproxylic beetle assemblages, although it is known that the Mediterranean is a biodiversity hotspot with a long-lasting human pressure on natural habitats. We provide an overview of saproxylic beetle assemblages of three forest types (mature Pinus halepensis forests, mature Pinus brutia forests, young Quercus calliprinos forests) in the East Mediterranean region using a one-year sample from 12 forest plots located in the north of Israel. T…

biologyQuercus calliprinosEcology/dk/atira/pure/core/keywords/559922418Beetle diversityForest managementSpecies diversityForestryManagement Monitoring Policy and Lawbiology.organism_classificationMiddle EastGeographyPinus brutiaAleppo PineMediterranean oaksForest ecologySecondary forestSpecies richnessCommunity ecologyIsraelPinesBiologyNature and Landscape Conservation
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Significance of the dorsal zigzag pattern of Vipera latastei gaditana against avian predators

2005

Summary 1. Aposematism is an antipredatory strategy in which prey animals conspicuously signal their noxiousness to potential predators. This successful strategy is based on avoidance learning of predators. 2. Most species in the viperid genus Vipera have a characteristic dorsal zigzag pattern. It has previously been suggested that the dorsal zigzag pattern of Vipera berus (the adder) has a cryptic function and thus makes the snake less conspicuous to avian predators. However, a recent experiment suggested that the pattern may function as an aposematic signal rather than being cryptic, and therefore induces active avoidance in avian predators. 3. We conducted a field experiment in Donana na…

biologyVipera berusEcologyOphidiaZoologyAposematismbiology.organism_classificationPredationlaw.inventionDisruptive colorationViperalawAnimal Science and ZoologyPlasticineVipera latasteiEcology Evolution Behavior and SystematicsJournal of Animal Ecology
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Measuring the Reputation of Top US Business Schools: A MIMIC Modeling Approach

2009

This article examines predictors of the reputation of top US business schools as perceived by three different stakeholders: business school deans, MBA candidates, and recruiters of MBA graduates. Reputation is modeled and later estimated via a Multiple Indicators and Multiple Causes model using LISREL methodology. The outcomes of the study show that the reputation of a business school is a unidimensional construct, implying homogeneity in the perceptions of the stakeholders analyzed, and fundamentally hinges on two antecedents: quality of students and position in the business school media rankings.

business.industryStrategy and ManagementBest practicemedia_common.quotation_subjectPublic relationsLISRELBusiness relationship managementCorporate reputationEmpirical researchPerceptionBusiness and International ManagementMarketingbusinessReputation managementmedia_commonReputationCorporate Reputation Review
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Observatory science with eXTP

2019

Disponible preprint en: arXiv:1812.04023v1 [astro-ph.HE] [v1] Mon, 10 Dec 2018 19:00:52 UTC (4,376 KB)

cataclysmic binariesAstronomyFIELD CAMERAS OBSERVATIONSspace research instruments nuclear astrophysics flare stars accretion and accretion disks mass loss and stellar winds cataclysmic binaries X-ray binaries supernova remnants active galactic nuclei X-ray bursts gamma-ray bursts gravitational wavesGeneral Physics and Astronomygamma-ray burstspace research instrument01 natural sciencesGamma ray burstsObservatoryAccretion and accretion disksAstrophysics::Solar and Stellar Astrophysics010303 astronomy & astrophysicsgravitational waveaccretion and accretion diskPhysicsHigh Energy Astrophysical Phenomena (astro-ph.HE)supernova remnants[SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph][SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE]flare starsgamma-ray burstsAstrophysics::Instrumentation and Methods for Astrophysicsaccretion and accretion disks; active galactic nuclei; cataclysmic binaries; flare stars; gamma-ray bursts; gravitational waves; mass loss and stellar winds; nuclear astrophysics; space research instruments; supernova remnants; X-ray binaries; X-ray bursts; Physics and Astronomy (all)Space research instrumentsX ray burstSupernovaX-ray binariesgravitational wavesaccretion and accretion disksQUIETHigh massX-ray binarieMass loss and stellar windsNuclear astrophysicsGamma-ray burstsspace research instrumentsAstrophysics - High Energy Astrophysical PhenomenaPULSAR-WIND NEBULAEFAST RADIO-BURSTSAstrofísica nuclearActive galactic nucleusTIDAL DISRUPTIONSupernova remnantsAstrophysics::High Energy Astrophysical Phenomenanuclear astrophysicsPolarimetryFOS: Physical sciencesAstrophysics::Cosmology and Extragalactic AstrophysicsACCRETING NEUTRON-STARSaccretion and accretion disks; active galactic nuclei; cataclysmic binaries; flare stars; gamma-ray bursts; gravitational waves; mass loss and stellar winds; nuclear astrophysics; space research instruments; supernova remnants; X-ray binaries; X-ray burstsGravitational wavesPhysics and Astronomy (all)cataclysmic binarieSettore FIS/05 - Astronomia e AstrofisicaSUPERMASSIVE BLACK-HOLES0103 physical sciences010306 general physicsX-ray burstAstrophysics::Galaxy AstrophysicsCataclysmic binariesActive galactic nucleiflare starAstronomyWhite dwarfFlare starsStarssupernova remnantQB460-466 Astrophysics[SDU]Sciences of the Universe [physics]mass loss and stellar wind:Física::Astronomia i astrofísica [Àrees temàtiques de la UPC]active galactic nucleiX-RAYX-ray burstsSupernova remmantsmass loss and stellar windsX ray binaries[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]SEYFERT 1 GALAXYnuclear astrophysic
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Dealing with interruptions in text-based chat sessions

2010

Running a teaching session that achieves its aims and objectives requires organised and structured dialogue between teacher and students that leaves room for a clear line of instructions. However, participants can disrupt the flow and prevent the achievement of these objectives through constant interruption (via questions or comments). The interruptions mentioned here include any discursive interaction that halts the flow of the argument and causes distraction for teacher and students.

chat disruption interaction
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Sequiterpene-related compounds as endocrine disrupters in Oncopeltus fasciatus, and potential reduced glutathione synthesis modifiers

1999

Sesquiterpene lactones have been found to exhibit effects on insect growth and development. In this study, the bioactivity of natural lactones extracted from Centaurea mariolensis and some structurally related synthetic derivatives has been investigated. Assays have also been carried out in order to determine the potential of these lactones as modifiers of reduced glutathione (GSH) synthesis.

chemistry.chemical_classificationEnvironmental EngineeringChemical compoundStereochemistryChemical structureBiological activityGlutathioneBiologySesquiterpenePollutionchemistry.chemical_compoundMechanism of actionchemistryBiochemistryEndocrine disruptormedicineEnvironmental Chemistrymedicine.symptomWaste Management and DisposalLactoneScience of The Total Environment
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