Search results for "Influenza"

showing 10 items of 263 documents

Sociodemographic Factors and Clinical Conditions Associated to Hospitalization in Influenza A (H1N1) 2009 Virus Infected Patients in Spain, 2009–2010

2012

The emergence and pandemic spread of a new strain of influenza A (H1N1) virus in 2009 resulted in a serious alarm in clinical and public health services all over the world. One distinguishing feature of this new influenza pandemic was the different profile of hospitalized patients compared to those from traditional seasonal influenza infections. Our goal was to analyze sociodemographic and clinical factors associated to hospitalization following infection by influenza A(H1N1) virus. We report the results of a Spanish nationwide study with laboratory confirmed infection by the new pandemic virus in a case-control design based on hospitalized patients. The main risk factors for hospitalizatio…

MaleViral DiseasesPediatricsNon-Clinical MedicinePulmonologyEpidemiology:Named Groups::Persons::Age Groups::Adult::Aged::Aged 80 and over [Medical Subject Headings]Grip A (H1N1):Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]DiseaseSocial and Behavioral Sciencesmedicine.disease_cause:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings]Hospital patients:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Influenza A Virus H1N1 SubtypeGripe humanaSociologyRisk FactorsPandemicInfluenza A virusChildAged 80 and over:Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings]:Organisms::Viruses::Vertebrate Viruses::RNA Viruses::Orthomyxoviridae::Influenzavirus A::Influenza A virus::Influenza A Virus H1N1 Subtype [Medical Subject Headings]COPDeducation.field_of_studyMultidisciplinary:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies [Medical Subject Headings]:Named Groups::Persons::Age Groups::Child::Child Preschool [Medical Subject Headings]QRMiddle AgedHospitalizationInfectious Diseases:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Hospitalization [Medical Subject Headings]Child Preschool:Named Groups::Persons::Age Groups::Adolescent [Medical Subject Headings]MedicineFemalePublic Health:Named Groups::Persons::Age Groups::Infant [Medical Subject Headings]Assistència hospitalàriaResearch ArticleAdultmedicine.medical_specialtyAdolescent:Named Groups::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings]SciencePopulationHospitals -- Pacients:Check Tags::Male [Medical Subject Headings]:Named Groups::Persons::Age Groups::Infant::Infant Newborn [Medical Subject Headings]InfluenzavirusVirusYoung AdultInfluenza HumanSubtipo H1N1 del Virus de la Influenza A:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]medicineInfluenza virusesHumansEpidemiologia -- Investigació -- EspanyaEspanyaEpidemiologiaeducationPandemicsBiology:Named Groups::Persons::Age Groups::Child [Medical Subject Headings]AgedHospital carePopulation Biologybusiness.industryPublic healthInfant NewbornCase-control studyInfant:Health Care::Environment and Public Health::Public Health::Disease Outbreaks::Epidemics::Pandemics [Medical Subject Headings]medicine.disease:Check Tags::Female [Medical Subject Headings]SpainCase-Control StudiesH1N1 influenza:Diseases::Virus Diseases::RNA Virus Infections::Orthomyxoviridae Infections::Influenza Human [Medical Subject Headings]businessPLoS ONE
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Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors

2012

The H1N1 influenza pandemic strain has been associated with a poor prognosis in hospitalized patients. The present report evaluates the factors influencing prognosis.A total of 813 patients hospitalized with H1N1 influenza in 36 hospitals (nationwide) in Spain were analysed. Detailed histories of variables preceding hospital admission were obtained by interview, validating data on medications and vaccine with their attending physicians. Data on treatment and complications during hospital stay were recorded. As definition of poor outcome, the endpoints of death and admission to intensive care were combined; and as a further outcome, length of stay was used.The mean age was 38.5 years (SD 22.…

Malemedicine.disease_causeInfluenza A Virus H1N1 SubtypepreventionPregnancyInfluenza A virusPharmacology (medical)Young adultChildOriginal ResearchAged 80 and overNeuraminidase inhibitorbiologyMiddle AgedPrognosisHospitalizationInfectious DiseasesChild PreschoolFemaleMicrobiology (medical)Adultmedicine.medical_specialtyAdolescentCritical Caremedicine.drug_classNeuraminidaseadverse outcomesAntiviral AgentsYoung Adultlength of stayInternal medicineDiabetes mellitusIntensive careInfluenza HumanmedicineHumansSurvival analysisAgedPharmacologyPregnancyflubusiness.industrypandemicInfant NewbornInfantLength of Staymedicine.diseaseSurvival AnalysisSpainImmunologybiology.proteinbusinessNeuraminidase
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Effects of prophylactic ibuprofen and paracetamol administration on the immunogenicity and reactogenicity of the 10-valent pneumococcal non-typeableH…

2016

ABSTRACT Prophylactic paracetamol administration impacts vaccine immune response; this study (www.clinicaltrials.gov: NCT01235949) is the first to assess PHiD-CV immunogenicity following prophylactic ibuprofen administration. In this phase IV, multicenter, open-label, randomized, controlled, non-inferiority study in Romania (November 2010–December 2012), healthy infants were randomized 3:3:3:1:1:1 to prophylactically receive immediate, delayed or no ibuprofen (IIBU, DIBU, NIBU) or paracetamol (IPARA, DPARA, NPARA) after each of 3 primary doses (PHiD-CV at age 3/4/5 months co-administered with DTPa-HBV-IPV/Hib at 3/5 and DTPa-IPV/Hib at 4 months) or booster dose (PHiD-CV and DTPa-HBV-IPV/Hib…

Malemedicine.medical_specialtyAntipyreticsparacetamolImmunologyIbuprofenBooster doseDiphtheria-Tetanus-acellular Pertussis Vaccinesmedicine.disease_causeGastroenterologyHaemophilus influenzaePneumococcal Vaccines03 medical and health sciences0302 clinical medicinevaccine030225 pediatricsInternal medicinemedicineHumansImmunology and Allergy030212 general & internal medicineAntipyretic10-valent pneumococcal conjugateAcetaminophenfeverPharmacologyReactogenicityRomaniabusiness.industryIncidenceorganic chemicalsImmunogenicityInfantIbuprofenResearch PapersAntibodies BacterialHealthy VolunteersAcetaminophenVaccinationTreatment OutcomeImmunologyFemaleprophylaxisbusinessmedicine.drugHuman Vaccines & Immunotherapeutics
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Smoking may increase the risk of influenza hospitalization and reduce influenza vaccine effectiveness in the elderly.

2017

Background Through its effects on the immune system, smoking may facilitate influenza virus infection, its severity and its most frequent complications. The objective was to investigate the smoking history as a risk factor for influenza hospitalization and influenza vaccine effectiveness in elderly smokers/ex-smokers and non-smokers. Methods We carried out a multicenter case-control study in the 2013-2014 and 2014-2015 influenza seasons. Cases aged ≥65 years and age-, sex-matched controls were selected from 20 Spanish hospitals. We collected epidemiological variables, comorbidities, vaccination history and the smoking history. The risk of hospitalization due to smoking (current smokers and …

Malemedicine.medical_specialtyInfluenza vaccineComorbidity03 medical and health sciences0302 clinical medicineRisk FactorsInternal medicineEpidemiologyInfluenza HumanMedicineHumans030212 general & internal medicineRisk factorGeriatric AssessmentAgedAged 80 and overbusiness.industrySmokingPublic Health Environmental and Occupational HealthCase-control studyOdds ratiomedicine.diseaseComorbidityVaccinationHospitalizationIncreased riskTreatment Outcome030228 respiratory systemInfluenza VaccinesSpainCase-Control StudiesFemaleMedical emergencybusinessEuropean journal of public health
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Influenza Vaccination After Myocardial Infarction:A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial

2021

Background: Observational and small, randomized studies suggest that influenza vaccine may reduce future cardiovascular events in patients with cardiovascular disease. Methods: We conducted an investigator-initiated, randomized, double-blind trial to compare inactivated influenza vaccine with saline placebo administered shortly after myocardial infarction (MI; 99.7% of patients) or high-risk stable coronary heart disease (0.3%). The primary end point was the composite of all-cause death, MI, or stent thrombosis at 12 months. A hierarchical testing strategy was used for the key secondary end points: all-cause death, cardiovascular death, MI, and stent thrombosis. Results: Because of the COV…

Malemedicine.medical_specialtyInfluenza vaccineMEDLINEMyocardial Infarction030204 cardiovascular system & hematologyPlacebolaw.invention03 medical and health sciences0302 clinical medicineRandomized controlled trialDouble-Blind MethodlawPhysiology (medical)Multicenter trialInternal medicineinfluenza vaccinesmedicineHumans030212 general & internal medicineMyocardial infarctionbusiness.industryMiddle Agedmedicine.disease3. Good healthVaccinationTreatment Outcomemyocardial infarctionInfluenza Vaccinesrandomized controlled trialObservational studyFemaleCardiology and Cardiovascular Medicinebusiness
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Influenza vaccine concurrently administered with a combination measles, mumps, and rubella vaccine to young children.

2010

Children aged 11 to <24 months received 2 intranasal doses of live attenuated influenza vaccine (LAIV) or placebo, 35+/-7 days apart. Dose 1 was administered concomitantly with a combined measles, mumps, and rubella vaccine (Priorix). Seroresponses to measles and mumps were similar between groups. Compared with placebo, response rates to rubella in LAIV+Priorix recipients were statistically lower at a 15 IU/mL threshold (83.9% vs 78.0%) and the prespecified noninferiority criteria were not met. In a post hoc analysis using an alternate widely accepted threshold of 10 IU/mL, the noninferiority criteria were met (93.4% vs 89.8%). Concomitant administration with Priorix did not affect the over…

Malemedicine.medical_specialtyMeasles-Mumps-Rubella VaccineInfluenza vaccineAntibodies ViralVaccines AttenuatedRubellaMeaslesDrug IncompatibilityPlacebosRubella vaccineInternal medicineInfluenza HumanmedicineLive attenuated influenza vaccineHumansVaccines CombinedMumpsAdministration IntranasalRubellaGeneral VeterinaryGeneral Immunology and Microbiologybusiness.industryVaccinationPublic Health Environmental and Occupational HealthInfantmedicine.diseaseVaccinationInfectious DiseasesImmunizationInfluenza VaccinesImmunologyMolecular MedicineFemalebusinessMeasles-Mumps-Rubella Vaccinemedicine.drugMeaslesVaccine
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Moderate influenza vaccine effectiveness against A(H1N1)pdm09 virus, and low effectiveness against A(H3N2) subtype, 2018/19 season in Italy

2019

Background: Influenza vaccines are updated every year to match the vaccine strains with currently circulating viruses; consequently influenza vaccine effectiveness (IVE) has to be assessed annually.Research design and methods: A test-negative case-control study was conducted within the context of the Italian sentinel influenza surveillance network to estimate IVE by age group, virus subtype, and vaccine brand in medically attended laboratory-confirmed influenza.Results: In Italy, the 2018/19 influenza season was characterized by the co-circulation of influenza A(H1N1)pdm09 and A(H3N2) viruses. The adjusted IVE estimate in preventing influenza was moderate (44.8%, 95% CI: 18.8 to 62.5) again…

Maletest-negative case-control study0301 basic medicinePrevalenceInfluenza vaccine effectiveness test-negative case-control study national influenza surveillance network ItalySettore MED/42 - Igiene Generale E ApplicataInfluenza A Virus H1N1 Subtype0302 clinical medicineDrug DiscoveryEpidemiology030212 general & internal medicineChildInfluenza vaccine effectivenessAged 80 and overnational influenza surveillance networkAge Factorsvirus diseasesMiddle Aged3. Good healthVaccinationTreatment OutcomeItalyInfluenza VaccinesChild PreschoolMolecular MedicineFemaleInfluenza vaccine effectiveness; Italy; national influenza surveillance network; test-negative case-control studyAdultmedicine.medical_specialtyAdolescentInfluenza vaccineImmunologyContext (language use)VirusYoung Adult03 medical and health sciencesInternal medicineInfluenza HumanmedicineAnimalsHumansAgedPharmacologybusiness.industryInfluenza A Virus H3N2 SubtypeCase-control studyInfant030104 developmental biologyImmunizationCase-Control StudiesbusinessExpert Review of Vaccines
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Viral Infections in Neonates with Suspected Late-Onset Bacterial Sepsis—A Prospective Cohort Study

2016

Objective The aim of our study was to evaluate the occurrence of viral infections in infants with suspected late-onset bacterial sepsis in a neonatal intensive care unit. Methods In a prospective study, infants with suspected late-onset bacterial sepsis underwent viral testing alongside routine blood culture sampling. Using a multiplex reverse transcription-polymerase chain reaction enzyme-linked immunosorbent assay, nasopharyngeal aspirates were analyzed for adenovirus, respiratory syncytial virus (RSV), influenza virus A and B, H1N1 virus, parainfluenza virus 1 to 4, metapneumovirus, coronavirus, and picornavirus. Stools were examined for adenovirus, rotavirus, norovirus, and enterovirus.…

MalevirusesBacteremiamedicine.disease_causeLate Onset DisordersAdenovirus Infections HumanCohort StudiesFeces0302 clinical medicineRotavirusGermanyNasopharynxBlood culture030212 general & internal medicineProspective StudiesCoronavirusCaliciviridae InfectionsParamyxoviridae InfectionsNeonatal sepsismedicine.diagnostic_testReverse Transcriptase Polymerase Chain ReactionObstetrics and Gynecologyvirus diseasesVirus DiseasesOriginal ArticleFemaleNeonatal SepsisCoronavirus InfectionsEnzyme-Linked Immunosorbent AssayvirusRespiratory Syncytial Virus InfectionsRotavirus InfectionsSepsis03 medical and health sciences030225 pediatricsIntensive Care Units NeonatalInfluenza HumanmedicineEnterovirus InfectionsHumanslate-onset bacterial sepsisPicornaviridae Infectionsbusiness.industryInfant Newbornmedicine.diseaseVirologyneonatal intensive care unitinfectionBlood CultureBacteremiaPediatrics Perinatology and Child HealthImmunologyNorovirusEnterovirusbusinessMultiplex Polymerase Chain ReactionAmerican Journal of Perinatology
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Effectiveness of an educational intervention on seasonal influenza vaccination campaign adherence among healthcare workers of the Palermo University …

2018

Introduction. Healthcare workers are continuously exposed to the risk of being infected by influenza viruses during their work, thus representing a threat especially for fragile patients. Although the Italian Ministry of Health strongly recommends influenza vaccination for all HCWs, coverage levels in Italy are still far from the expected. Several studies report that one of the preferred strategies to improve vaccination coverage among Healthcare Workers is improving vaccination knowledge through specific multidisciplinary courses. To assess the effectiveness of an educational intervention on influenza vaccination coverage among Healthcare Workers a study was conducted at "Paolo Giaccone" U…

Medical educationMaleRisk perceptionVaccination CoverageImmunization ProgramsHealth PersonnelVaccinationPublic Health Environmental and Occupational HealthInfluenza vaccinationHospitals UniversityInfectious DiseasesItalyInfluenza VaccinesSurveys and QuestionnairesInfluenza HumanHumansFemaleSeasonsAnnali di igiene : medicina preventiva e di comunita
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Comparison of the performance of 2 commercial multiplex PCR platforms for detection of respiratory viruses in upper and lower tract respiratory speci…

2015

The performance of the CLART® PneumoVir system with that of the Luminex xTAG RVP Fast v1 assay for detection of most common respiratory viruses in upper and lower tract respiratory specimens (n = 183) from unique patients with influenza-like syndrome or lower tract respiratory infection. Nested PCR coupled to automated sequencing was used for resolution of discrepancies. Fully concordant results were obtained for a total of 122 specimens, whereas 56 specimens gave partially (n = 21) or fully discordant (n = 35) results (Kappa coefficient, 0.62). The overall specificity of the Luminex xTAG RVP Fast v1 assay was slightly higher than that of the CLART® PneumoVir assay for human bocavirus, infl…

Microbiology (medical)AdultMaleAcute respiratory tract infectionAdolescentvirusesRespiratory Systemmedicine.disease_causeSensitivity and SpecificityVirusArticleYoung AdultHuman metapneumovirusMultiplex polymerase chain reactionInfluenza A virusmedicineHumansAcute respiratory tract infectionRespiratory Tract InfectionsAgedRetrospective StudiesAged 80 and overRespiratory virusesbiologyHuman bocavirusRespiratory infectionvirus diseasesGeneral MedicineMultiplex PCRMiddle Agedbiology.organism_classificationVirologyrespiratory tract diseasesInfectious DiseasesVirus DiseasesVirusesFemaleNested polymerase chain reactionMultiplex Polymerase Chain ReactionDiagnostic Microbiology and Infectious Disease
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