Search results for "Instability"
showing 10 items of 724 documents
Helicobacter pylori and Epstein–Barr Virus Co-Infection in Gastric Disease: What Is the Correlation with p53 Mutation, Genes Methylation and Microsat…
2023
Genetic predisposition, environmental factors, and infectious agents interact in the development of gastric diseases. Helicobacter pylori (Hp) and Epstein–Barr virus (EBV) infection has recently been shown to be correlated with these diseases. A cross-sectional study was performed on 100 hospitalized Italian patients with and without gastric diseases. The patients were stratified into four groups. Significant methylation status differences among CDH1, DAPK, COX2, hMLH1 and CDKN2A were observed for coinfected (Hp-EBV group) patients; particularly, a significant presence of COX2 (p = 0.0179) was observed. For microsatellite instability, minor stability was described in the Hp-HBV group (69.23…
Expression of a mutant HSP110 sensitizes colorectal cancer cells to chemotherapy and improves disease prognosis
2011
Heat shock proteins (HSPs) are necessary for cancer cell survival. We identified a mutant of HSP110 (HSP110ΔE9) in colorectal cancer showing microsatellite instability (MSI CRC), generated from an aberrantly spliced mRNA and lacking the HSP110 substrate-binding domain. This mutant was expressed at variable levels in almost all MSI CRC cell lines and primary tumors tested. HSP110ΔE9 impaired both the normal cellular localization of HSP110 and its interaction with other HSPs, thus abrogating the chaperone activity and antiapoptotic function of HSP110 in a dominant-negative manner. HSP110ΔE9 overexpression caused the sensitization of cells to anticancer agents such as oxaliplatin and 5-fluorou…
Muscle activation during push-ups performed under stable and unstable conditions
2015
Background/Objective: The purpose of this study was to analyze muscle activation when performing push-ups under different stability conditions. Methods: Physically fit young male university students (N = 30) performed five push-ups under stable conditions (on the floor) and using four unstable devices (wobble board, stability disc, fitness dome, and the TRX Suspension Trainer). The push-up speed was controlled using a metronome, and the testing order was randomized. The average amplitudes of the electromyographic (EMG) root mean square of the anterior deltoid (DELT), serratus anterior (SERRA), lumbar multifidus (LUMB), and rectus femoris (FEM) were recorded. The electromyographic signals we…
A free boundary problem stemmed from combustion theory. Part II: Stability, instability and bifurcation results
2002
AbstractWe deal with a free boundary problem, depending on a real parameter λ, in a infinite strip in R2, providing stability, instability and bifurcation.
Postinflationary vacuum instability and Higgs-inflaton couplings
2016
The Higgs-inflaton coupling plays an important role in the Higgs field dynamics in the early Universe. Even a tiny coupling generated at loop level can have a dramatic effect on the fate of the electroweak vacuum. Such Higgs-inflaton interaction is present both at the trilinear and quartic levels in realistic reheating models. In this work, we examine the Higgs dynamics during the preheating epoch, focusing on the effects of the parametric and tachyonic resonances. We use lattice simulations and other numerical tools in our studies. We find that the resonances can induce large fluctuations of the Higgs field which destabilize the electroweak vacuum. Our considerations thus provide an upper …
Tibial tubercle osteotomy: effect of different osteotomy planes on contact surface area and tubercle anteriorization
2022
In 1983, Fulkerson introduced a technique of tibial tubercle osteotomy performed according to an inclined plane with respect to frontal plane. Due to obliquity of the osteotomy plane, this procedure allows both anterior and medial transfer of the tibial tubercle. The purpose of the study was to investigate the influence of the different degrees of the oblique plane of osteotomy on anterior displacement and the contact surface area of tibial tubercle. Synthetic bones were used for the study. An osteotomy of the tibial tubercle (TT) was performed in each specimen. Specifically, 3 different degrees of osteotomy planes relative to the reference frontal plane were examined: 20°, 30° and 40°. On …
Microsatellite Instability in Colorectal Cancer: Time to Stop Hiding!
2011
Colorectal cancer (CRC) is the second cause of cancer-related death worldwide. Surgery constitutes the primary therapy for these tumors, together with chemotherapy that is usually recommended in patients with metastatic primary CRC. Although molecularly distinct entities arising from different physiopathogenic mechanisms - microsatellite (MSI) and chromosomal instability (also called microsatellite stable, MSS) - have been characterized in CRC, there is still no specific therapeutic approach that takes into account disease’s molecular heterogeneity [1]. MSI is observed in 1015% of sporadic CRCs. MSI CRCs displayed particular morphologic features, with greater predilection for the right colo…
Pattern formation driven by cross–diffusion in a 2D domain
2012
Abstract In this work we investigate the process of pattern formation in a two dimensional domain for a reaction–diffusion system with nonlinear diffusion terms and the competitive Lotka–Volterra kinetics. The linear stability analysis shows that cross-diffusion, through Turing bifurcation, is the key mechanism for the formation of spatial patterns. We show that the bifurcation can be regular, degenerate non-resonant and resonant. We use multiple scales expansions to derive the amplitude equations appropriate for each case and show that the system supports patterns like rolls, squares, mixed-mode patterns, supersquares, and hexagonal patterns.
New Roles for Media in the Western Balkans
2017
After almost 20 years of political instability and ongoing conflicts in the Western Balkans, the region is still haunted by the past, and there is an ongoing synergy of influence between media and the political sector. Media in this region have frequently been criticized for fueling conflicts, instigating ethnic hatred and taking political sides. This article suggests a new research agenda in the practice of transitional journalism in this part of Southeastern Europe. This research strand combines elements from troubled pasts, war reporting, peace journalism and issues of transitional justice. This article analyzes how journalists in the Western Balkans consider the roles of journalism in t…
NREM Sleep Instability in Pediatric Migraine Without Aura
2019
Children with migraine headaches appear to have a range of sleep disturbances. The aim of the present study was to assess the NREM sleep instability in a population of school-aged individuals affected by migraine without aura (MoA). Thirty-three children with MoA (20 males, 13 females, mean age 10.45 ± 2.06 years) underwent to overnight Polysomnographic (PSG) recordings and Cyclic Alternating Pattern (CAP) analyses accordingly with international criteria. MoA group showed a reduction in sleep duration parameters (TIB, SPT, TST; p ≤ 0.001 for all) and in arousal index during REM sleep and an increase in awakenings per hour (AWK/h) vs. Controls (C) (p = 0.008). In particular, MoA children sho…