Search results for "Integumentary system"
showing 10 items of 744 documents
First International Merkel Cell Symposium, Heidelberg, Germany
1995
Clinical evaluation of melanomas and common nevi by spectral imaging
2012
A clinical trial on multi-spectral imaging of malignant and non-malignant skin pathologies comprising 17 melanomas and 65 pigmented common nevi was performed. Optical density data of skin pathologies were obtained in the spectral range 450-950 nm using the multispectral camera Nuance EX. An image parameter and maps capable of distinguishing melanoma from pigmented nevi were proposed. The diagnostic criterion is based on skin optical density differences at three fixed wavelengths: 540nm, 650nm and 950nm. The sensitivity and specificity of this method were estimated to be 94% and 89%, respectively. The proposed methodology and potential clinical applications are discussed.
Diagnostic Concordance between Optical Coherence Tomography and Histological Investigations for Immune-Mediated Desquamative Gingivitis: Observationa…
2021
Desquamative gingivitis (DG) denotes a heterogeneous immune-mediated disease for which early diagnosis represents a great challenge. The main aim of this study is to validate diagnostic concordance between specific Optical Coherence Tomography (OTC) patterns for DG related to oral Lichen Planus (OLP), Pemphigus Vulgaris (PV), and Mucous Membrane Pemphigoid (MMP) and definitive histological diagnosis. Forty-three patients with suspected immune-mediated DGs, were progressively recruited. Before biopsy, an OCT preliminary evaluation was performed using specific pre-determined OCT diagnostic patterns (i.e., morphology and localization of blisters, status of the basal membrane, epithelial thickn…
Idiopathic Acquired Leukonychia in a 34-Year-Old Patient
2009
We present a rare case of a 34-year-old patient with persistent, progressive, acquired leukonychia totalis and partialis. Idiopathic acquired leukonychia is a rare chromatic disorder of the nail not associated with other abnormalities and discernible etiology. Our case report did not link the inheritance of leukonychia with diverse clinical syndromes. To our knowledge, only five cases of idiopathic, acquired, true total leukonychia were found in literature. This case was the sixth patient with asymptomatic idiopathic, white fingernails, and toenails without a hereditary cause.
Systemic lupus erythematosus and bullous pemphigoid with dramatic response to dapsone
2017
Patient: Female, 11 Final Diagnosis: Bullous pemphigoid in systemic lupus erythematosus Symptoms: Bullous lupus • photosensitive rash • synovitis Medication:— Clinical Procedure: Pharmacological treatment Specialty: Rheumatology Objective: Unusual clinical course Background: Bullous pemphigoid is an autoimmune blistering disease, with relapses, isolated or associated with other autoimmune diseases such as systemic lupus erythematosus (SLE). Joint manifestations rapidly respond to small or moderate doses of corticosteroids, whereas skin manifestations usually respond to antimalarial drugs. Case Report: We describe the clinical case of an 11-year-old girl with SLE. She showed bullous skin les…
Dielectric characterization of biocompatible hydrogels for application to Epidermal RFID devices
2015
Functionalized skin-like membranes are currently under investigation for the design of a new class of Epidermal Electronics devices for sensing and healing applications. The dynamic response of epidermal antennas in presence of absorption and release of fluids is a key-point to design RFID radio-sensors and actuators. This paper addresses the characterization of the dielectric property of PVA-based biocompatible hydrogel membranes in the UHF RFID band by means of a modified ring resonator. Samples having different compositions are measured in the dry state as well as when exposed to a progressive release of body fluids emulating perspirations or wound exudates. It was found that the permitt…
Biopartitioning micellar chromatography to predict skin permeability
2003
Dermal absorption of chemicals is an area of increasing interest to the pharmaceutical and cosmetic industries, as well as in dermal exposure and risk assessment processes. In this paper the capability of biopartitioning micellar chromatography (BMC) as an in vitro technique to describe compound percutaneous absorption is evaluated. A multivariate study (principal component analysis, partial least squares) is performed in order to evaluate the importance of some physicochemical variables on the skin permeability constant values. From these results, a quantitative retention-activity relationship model for predicting the skin permeability constants that uses the BMC retention data and melting…
Screening of antiinflammatory medicinal plants used in traditional medicine against skin diseases
1998
The antiinflammatory activity of twelve medicinal plants used against skin disorders were tested in different experimental models of topical inflammation and one in vitro inhibitory test against phospholipase A2 (PLA2) from Naja naja venom. Forsythia suspensa was the most active species on the arachidonic acid (AA) topical test. This last species together with Astragalus membranaceus and Ranunculus sceleratus were the most active on the 12-O-tetradecanoylphorbol-13-acetate (TPA) acute ear oedema test. Scrophularia auriculata was the most active on multiple topical applications of TPA and on the oxazolone-induced delayed type hypersensitivity (DTH). Santolina chamaecyparissus was the only sp…
Fine structure of sensilla during moulting inNeomysis integer (Leach) (Crustacea, Mysidacea)
1980
During the moulting cycle the sensory cells and the newly formed hair shaft remain connected to the old cuticular receptive apparatus of the sensillum by the elongated outer segments of the dendrites, which run through the exuvial space. A surface coat covering the outer dendritic segments protects them against the chemical influences of the exuvial fluid. The findings suggest that the receptors remain functional until ecdysis. This moulting type is considered to be a transitional form between the moulting types so far known.
Skin-remitted photon path lengths: experimental study
2020
Skin-remitted picosecond laser pulses were detected at four input-output fiber distances in the spectral range 560-800 nm. After deconvolution procedures, distributions and mean values of the remitted photon path lengths in forearm skin were analyzed.