Search results for "Integumentary system"
showing 10 items of 744 documents
Skin chromophore mapping from multi-spectral laser line images
2020
Skin chromophore maps can be used for assessment of various skin malformations and early cancer diagnostics. Commercially available devices are bulky and expensive. We present two portable proof-of-concept device prototypes for multi-spectral laser line imaging with three (448 nm, 532 nm and 659 nm) and four (450 nm, 523 nm, 638 nm and 850 nm) wavelength laser illumination. Laser modules and special optics that ensure uniform light distribution over the region of interest have been exploited. Skin chromophore maps were calculated using Beer-Lambert law, considering light scattering properties in the skin and including photon path length evaluated from the directly measured photon-time-of-fl…
Cricket combined mechanoreceptors and kicking response
1977
1. Only those filiform hairs on the cerci ofGryllus, which are coupled with campaniform sensilla, show a) a thickening of the hair shaft at the height of the upper ring lamella of their sockets and b) a thin cuticular membrane, which surrounds their sockets. While thefiliform hairs themselves are deflected either parallel to the long axis of the cerci or perpendicular to it, thesockets of the filiform hairs may be deflected preferentially in the proximal and distal direction. 2. Spike potentials can be recorded from the sensory cells of the filiform hairs as long as these are deflected in a weak air current, but not during permanent deflection in strong air streams when they touch the inner…
Electron-pion discrimination with a scintillating fiber calorimeter
1990
Abstract We report on an experimental study of a variety of techniques for discriminating between (isolated) electrons and pions in a lead and scintillating fiber calorimeter without longitudinal segmentation. Using information from the lateral shower development, from a pre-shower detector, from the time structure of the signals, or from a combination of these we measure pion rejection factors of up to several thousand while maintaining electron efficiencies of 95% or higher.
Nanoencapsulation in Lipid-Core Nanocapsules Controls Mometasone Furoate Skin Permeability Rate and Its Penetration to the Deeper Skin Layers
2013
<b><i>Aims:</i></b> The influence of nanoencapsulation of mometasone furoate (MF) in poly(ε-caprolactone) lipid-core nanocapsules (LNC) on its in vitro human skin permeation and penetration was evaluated. <b><i>Methods:</i></b> Semisolid formulations were prepared by increasing the viscosity of LNC using a carbomer (Carbopol® Ultrez at 0.5% w/v). Two complementary techniques (the static Franz diffusion cell model and the Saarbrücken penetration model) were used to evaluate skin permeation/penetration. <b><i>Results:</i></b> The drug release rate was decreased by nanoencapsulation. The skin permeability of MF was control…
Safety and efficacy of novel dermal and epidermal microneedle delivery systems for rabies vaccination in healthy adults.
2010
International audience; In the present pilot study, intradermal ID delivery systems with a BD microneedle from 1 to 3mm in length, and epidermal delivery (BD skin abrader) through abraded skin surface relative to standard intramuscular injection were evaluated. Circulating neutralizing antibodies were measured against the rabies virus after the Vero cells rabies vaccine was administered at D0, D7, D21 and D49. This clinical evaluation in 66 healthy volunteers shows that ID delivery using BD microneedle technology of 1/4 the IM antigen dose is safe, efficient and reliable, resulting in a protective seroconversion rate. In contrast, the epidermal delivery route did not produce an immune respo…
SEM-Untersuchungen an myxospermen Diasporen
1980
The epidermal structure of mucilage producing seeds and fruits before and after contact with water is studied. Main emphasis is laid on the elucidation of structural peculiarities of the dessicated mucilaginous substances.
Diffractive corneal inlay for presbyopia
2017
[EN] A conceptually new type of corneal inlays for a customized treatment of presbyopia is presented. The diffractive inlay consists on a small aperture disc having an array of micro-holes distributed inside the open zones of a Fresnel zone plate. In this way, the central hole of the disc lets pass the zero order diffraction and produces an extension of the depth of far focus of the eye, while the diffracted light through the holes in the periphery produce the near focus. Additionally, the micro-holes in the inlay surface fulfill the essential requirement of allowing the flow of nutrients through it to the cells of the corneal stroma. Theoretical and optical-bench experimental results for t…
Sumatriptan Succinate Transdermal Delivery Systems for The Treatment of Migraine
2007
We have successfully obtained sumatriptan transdermal systems with different polymer compositions: methyl cellulose (MC), polyvinyl pyrrolidone (PVP) and a polyvinyl pyrrolidone (PVP)-polyvinyl alcohol (PVA) mixture. The systems contained 1,2-propylenglycol (MC) or sorbitol as a plasticizer (PVP and PVP-PVA), methacrylate copolymer as an adhesive agent, and an occlusive liner. Azone (5%, w/w) was incorporated into all the systems as a percutaneous enhancer. Transdermal systems are thin, transparent and non-adhesive when in a dry state. The permeation of sumatriptan succinate across pig ear skin was studied using the systems prepared. The formulation with MC polymer produced a statistically …
Characterization of PLLA scaffolds for biomedical applications
2017
The porosity and pore size distribution of three-dimensional scaffolds have direct implications on their biomedical applications (tissue engineering, drug delivery, and wound dressing). Accordingly, in this paper, a fast, facile, and conservative method relying on low-field nuclear magnetic resonance (LF-NMR) for the evaluation of mean pore size and pore size distribution of polymeric scaffolds is reported. The applicability of the technique is demonstrated on poly-L-lactic acid scaffolds fabricated using the thermal induced phase separation. Results obtained through LF-NMR are successfully compared to scanning electron microscope and X-ray microcomputed tomography micrographs.
Oxidative stress and mitochondrial dysfunction in Kindler syndrome
2014
This is an Open Access article distributed under the terms of the Creative Commons Attribution License.-- et al.