Search results for "Intrinsic"

Inhibitory activities of short linear motifs underlie Hox interactome specificity in vivo

2015

Hox proteins are well-established developmental regulators that coordinate cell fate and morphogenesis throughout embryogenesis. In contrast, our knowledge of their specific molecular modes of action is limited to the interaction with few cofactors. Here, we show that Hox proteins are able to interact with a wide range of transcription factors in the live Drosophila embryo. In this context, specificity relies on a versatile usage of conserved short linear motifs (SLiMs), which, surprisingly, often restrains the interaction potential of Hox proteins. This novel buffering activity of SLiMs was observed in different tissues and found in Hox proteins from cnidarian to mouse species. Although th…

On Thermoeconomic Diagnosis of a Fouled Direct Expansion Coil: Effects of Induced Malfunctions on Quantitative Performance of the Diagnostic Technique

2017

Thermoeconomic diagnosis represents a promising technique for the detection of common faults in refrigeration systems, which are responsible of degradation in their energetic performance. Recently, the authors have carried out a sensitivity analysis of the performance of this method to the thermodynamic conditions of inlet air and to the geometry of the direct expansion coil, in case of degradation induced by evaporator fouling. The analysis showed that the method is able to detect this fault, but sometimes its quantitative assessments are not satisfactory. In order to understand more in-depth the origin of such results and identify margins for refinement of the technique, this paper is aim…

Formation of Levan from Raffinose by Levansucrase ofZymomonas mobilis

2004

Levansucrase (EC 2.4.1.10.) of Zymomonas mobilis 113S can perform the polymerisation of fructose moiety from raffinose to levan concomitantly with a release of non-catabolised melibiose into the medium. The kinetic parameters of the levansucrase-catalysed reaction provide even higher reaction velocities on raffinose as compared to sucrose, particularly at low substrate concentrations. A decreased value in the number of the average molecular mass (Mn = 1693 kDa), an increased intrinsic viscosity (η = 49.47 cm3/g), and a diminished Huggin's constant (K' = 0.67) are intrinsic to the levan synthesis from raffinose, indicating certain structural peculiarities compared to a polysaccharide obtaine…

A role for caspases in the differentiation of erythroid cells and macrophages

2007

Several cysteine proteases of the caspase family play a central role in many forms of cell death by apoptosis. Other enzymes of the family are involved in cytokine maturation along inflammatory response. In recent years, several caspases involved in cell death were shown to play a role in other cellular processes such as proliferation and differentiation. In the present review, we summarize the current knowledge of the role of caspases in the differentiation of erythroid cells and macrophages. Based on these two examples, we show that the nature of involved enzymes, the pathways leading to their activation in response to specific growth factors, and the specificity of the target proteins th…

The influence of the physical education teacher on intrinsic motivation, self-confidence, anxiety, and pre-and post-competition mood states

2001

One of the fundamental problems facing teachers of physical education (PE) is how to increase pupils' motivation. From the point of view of goal achievement, guidelines need to be established so that information may be used to greater effect in classes. This study examined the relationship between the motivational climate created by the PE teacher and the intrinsic motivation of the preparatory sessions together with self-confidence and anxiety prior to competition and pre- and post-competition mood states. The sample was made up of school children (M age = 11.7) from a state school (N = 115), who, after an introduction to an athletics course of 12 sessions, took part in a sports competitio…

Expanding the Active Inference Landscape: More Intrinsic Motivations in the Perception-Action Loop

2018

Active inference is an ambitious theory that treats perception, inference and action selection of autonomous agents under the heading of a single principle. It suggests biologically plausible explanations for many cognitive phenomena, including consciousness. In active inference, action selection is driven by an objective function that evaluates possible future actions with respect to current, inferred beliefs about the world. Active inference at its core is independent from extrinsic rewards, resulting in a high level of robustness across e.g.\ different environments or agent morphologies. In the literature, paradigms that share this independence have been summarised under the notion of in…

An infinite family of counterexamples to a conjecture on positivity

2021

Recently, G. Mason has produced a counterexample of order 128 to a conjecture in conformal field theory and tensor category theory in [Ma]. Here we easily produce an infinite family of counterexamples, the smallest of which has order 72.

Solution properties of polyelectrolytes. III. Effect of sodium polystyrene sulfonate concentration on viscometric and size exclusion chromatographic …

1988

The effect of sodium polystyrene sulfonate concentration on the shape of its molecules in aqueous solution at different NaNO3 ionic strengths has been analyzed by viscometry and size-exclusion chromatography (s.e.c). An equation has been developed which predicts the intrinsic viscosity, [η] p.cp.cs, at finite concentration of both polyion (cp) and electrolyte (cs). The experimental results obtained by both techniques can be accounted for in terms of the theory. Several factors involved in the elution mechanism have been considered and the variation of the slopes of s.e.c. calibration curves with cp and cs has been discussed in terms of polyion conformation changes.

2013

Clusterin, also known as apolipoprotein J, is expressed from a variety of tissues and implicated in pathological disorders such as neurodegenerative diseases, ischemia and cancer. In contrast to secretory clusterin (sCLU), which acts as an extracellular chaperone, the synthesis, subcellular localization and function(s) of intracellular CLU isoforms is currently a matter of intense discussion. By investigating human CLU mRNAs we here unravel mechanisms leading to the synthesis of distinct CLU protein isoforms and analyze their subcellular localization and their impact on apoptosis and on NF-κB-activity. Quantitative PCR-analyses revealed the expression of four different stress-inducible CLU …

Polymer dynamics in thin p-type conducting films investigated by ac-electrogravimetry. Kinetics aspects on anion exclusion, free solvent transfer, an…

2015

A new transfer model is proposed to explain ac-electrogravimetry response of p-doped films. This model takes into account the exclusion effect occurring as a result of the anion transfer. The insertion/expulsion of anions inside a film involves simultaneously the expulsion/insertion of free solvent molecules. The number of solvent molecules excluded depends on the volume of anion transferred. Solvent transfer stimulated by the conformational changes of films constitutes the remaining electrogravimetric response when the exclusion process cannot explain by itself this response. Consequently, the kinetics of this free solvent transfer can be directly related to the kinetics of conformational …