Search results for "Juva"

Optimizing the Choice for Adjuvant Chemotherapy in Gastric Cancer.

2022

Advances in the management of gastric cancer have improved patient survival in the last decade. Nonetheless, the number of patients relapsing and dying after a diagnosis of localized gastric cancer is still too high, even in early stages (10% in stage I). Adjuvant systemic chemotherapy has been proven to significantly improve outcomes. In the present article we have critically reviewed the clinical trials that guide the current clinical practice in the adjuvant treatment of patients affected by resectable gastric cancer, focusing on the different approaches worldwide, i.e., adjuvant chemotherapy, adjuvant chemoradiotherapy, and perioperative chemotherapy. We also delineate the clinical–path…

Immunization of rainbow trout, Oncorhynchus mykiss (Walbaum), with a low molecular mass fraction isolated from Flavobacterium psychrophilum.

2008

Flavobacterium psychrophilum, the causative agent of rainbow trout fry syndrome has become a widespread fish pathogen in freshwater aquaculture worldwide. In this study, a low molecular mass fraction (P25-33), with an approximate weight of 25-33 kDa, was identified among F. psychrophilum strains in an immunoblotting analysis with anti-F. psychrophilum sera. The immunogenic efficacy of the isolated and extracted P25-33 was investigated in two intraperitoneal immunization trials with rainbow trout, Oncorhynchus mykiss (Walbaum). The first trial included immunizations using P25-33 with Freund's complete adjuvant (FCA) and the second trial included immunizations using P25-33, formalin-inactivat…

The efficacy of two immunostimulants against Flavobacterium columnare infection in juvenile rainbow trout (Oncorhynchus mykiss).

2009

Abstract Bacterium Flavobacterium columnare is the causative agent of columnaris disease in many wild and farmed fish species. Immunostimulants are used with success in aquaculture against many pathogens, but the ability to improve innate resistance to columnaris disease has not been studied. Fingerling rainbow trout were treated with two immunostimulants, yeast β-glucan and β-hydroxy-β-methylbutyrate (HMB). Selected innate immune function parameters, the production of reactive oxygen species (ROS) by whole blood and by isolated head kidney leukocytes, plasma lysozyme activity and complement bacteriolytic activity, were determined to assess the immune status of fish. The fish were then bath…

Inhibition of Lymphocyte Proliferation during Parasitic Infection with Nippostrongylus Brasiliensis

1979

It is now well established that parasitic infections can lead to the production of high titers of IgE anti parasitic antibodies in experimental animals and in man (1,2). One of the best studied experimental systems involves the ability of the nematode parasite Nippostrongylus brasiliensis (N.B.) to stimulate a high titer reaginic antibody response to worm antigens in the rat. These studies were extended by the reports of Orr and Blair that parasitic infections can cause non specific proliferation of IgE antibody response against antigens unrelated to those of the parasite (3). The amplification of an already existing IgE antibody response can be induced before infection by inoculating the a…

A prospective observational study on oral administration of Ellagic Acid and Annona Muricata in patients affected by non-muscle invasive bladder canc…

2021

Introduction: BCG and MMC shortage and Covid-19 pandemic, more recently, limit accessibility to maintenance regimen in intravesical prophylaxis against recurrence of non-muscle invasive bladder cancer (NMIBC). Ellagic acid (EA) and Annona muricata (AM) exert antitumor activity against different human tumours. An observational prospective study on the prophylactic effect of oral administration of EA+AM in patients avoiding maintenance regimen is presented. Materials and methods: Patients affected by NMIBC and not undergoing maintenance after a 6-week course of intravesical prophylaxis with MMC or BCG were entered. Tis and very high-risk tumours were excluded. After informed consent, the pati…

Neoadjuvant treatment for locally advanced unresectable and borderline resectable pancreatic cancer: oncological outcomes at a single academic centre.

2020

INTRODUCTION: Pancreatic cancer (PC), even in the absence of metastatic disease, has a dismal prognosis. One-third of them are borderline resectable (BRPC) or locally advanced unresectable PC (LAUPC) at diagnosis. There are limited prospective data supporting the best approach on these tumours. Neoadjuvant chemotherapy (ChT) is being increasingly used in this setting. METHODS: This is a retrospective series of consecutive patients staged as BRPC or LAUPC after discussion in the multidisciplinary board (MDB) at an academic centre. All received neoadjuvant ChT, followed by chemoradiation (ChRT) in some cases, and those achieving enough downstaging had a curative-intent surgery. Descriptive da…

Similarities and Differences: Signaling Mechanisms Induced by Contact Sensitizers

2003

Keeping in mind our detailed knowledge on the uptake, processing and presentation of protein antigens, little is known on the handling of contact sensitizers by antigen presenting cells (APC). Contact sensitizers have the unique capacity to activate APC without further adjuvant signals. Although numerous studies have addressed the cellular and functional changes during this process, little is known about the underlying signaling mechanisms.

The evidence of neuraxial administration of analgesics for cancer-related pain: a systematic review

2015

Background The present systematic review analysed the existing evidence of analgesic efficacy and side effects of opioids without and with adjuvant analgesics delivered by neuraxial route (epidural and subarachnoid) in adult patients with cancer. Methods Search strategy was elaborated with words related to cancer, pain, neuraxial route, analgesic and side effects. The search was performed in PubMed, EMBASE, and Cochrane for the period until February 2014. Studies were analysed according to methods, results, quality of evidence, and strength of recommendation. Results The number of abstracts retrieved was 2147, and 84 articles were selected for full reading. The final selection comprised nin…

The Benefits of the Adjuvant-Free Murine Experimental Asthma Model. Adjuvant and Adjuvant-Free Protocols Produce Similar Phenotypes.

2009

Hepatīta B kora antigēna veidoto vīrusveidīgo daļiņu modificēšana vakcīnu prototipa izstrādei

2017

DENV vakcīnu izveide balstās galvenokārt, izmantojot dzīvus novājinātus vīrusus. 2015. gadā tika reģistrēta pirmā tetravalenta novājināta denges vīrusa vakcīna. Kā drošāks vakcīnas veids ir subvienību vakcīnas. Daudzsološākais DENV antigēns subvienību vakcīnas izveidē ir apvalka proteīna III domēns. Lai palielinātu antigēna subvienības imunogenitāti, tiek izmantotas vīrusveidīgās daļiņas (VLP) kā svešu antigēnu nesēji. Tā kā VLP ir pašnereplicējošas, tās tiek uzskatītas par drošākiem kandidātiem vakcīnu izveidē, salīdzinot ar dzīviem novājinātiem vīrusiem. Maģistra darba mērķis bija iegūt 2. serotipa denges vīrusa apvalka III domēnu (DV2-III) prezentējošas mutantās HBc VLP. Pētījumā tika pā…