Search results for "LAB"
showing 10 items of 7932 documents
No labas ticības principa izrietošie līguma blakuspienākumi
2022
Civillikuma 1.pants noteic, ka: “Tiesības izlietojamas un pienākumi pildāmi pēc labas ticības”. Desmitiem tūkstošu spriedumu, kuros ietvertas atsauces uz šo pantu liecina par tā plašo atpazīstamību, tomēr gan tiesu praksē, gan tiesību doktrīnā joprojām pastāv neskaidrības par šī panta nozīmi. Autors analizēs un sniegs argumentētas atbildes uz šādiem problēmjautājumiem: 1) vai Civillikuma 1.pants ir uzskatāms tikai par rakstītu tiesību normu, vai arī tas ir nerakstītas tiesību normas atspoguļojums; 2) vai šajā pantā aprakstītais princips ir attiecināms tikai uz civiltiesībām; 3) kāds ir šī principa saturs, kodols, vēsturiskā attīstība, un kāda ir tā izpratne citu valstu tiesībās; 4) kādi ir …
Educating reflective Enterprise Systems practitioners: a design research study of the iterative building of a teaching framework
2013
This research paper reports on the iterative design of a teaching framework developed for teaching Enterprise Systems ES classes for Information Systems IS graduates. These systems embed technical complexity and create organizational challenges when implemented in organizations. Therefore, teaching good ES classes is pedagogically challenging for faculty, and ES curricula are difficult for students. We have gradually designed and rebuilt curricula and teaching frameworks over 8years. This has also resulted in a set of eight design principles. We report from our design and evaluation process and present our final artefact, the teaching framework. The aim is to educate reflective practitioner…
Teaching and learning in consumer behavior: a class activity supporting real decision-making in cultural management
2010
Abstract Problem-based learning has been suggested as a useful tool to foster student-centered learning and increase student motivation. Students of Business Administration are not familiar with Research on Consumer Behavior, its contents and techniques, since this subject is traditionally linked to Psychology. In order to facilitate the teaching-learning process in this subject, this paper presents an application of problem-based learning in the context of Consumer Behavior. Results of this pilot experience are assessed under a qualitative and a quantitative basis. The evidence obtained allow us to conclude that this collaboration project enable students to obtain and to process informatio…
Impulsive control of the bilinear Schrödinger equation: propagators and attainable sets
2019
International audience; We consider a linear Schrödinger equation with an unbounded bilinear control term. The control term is the derivative of function with bounded variations (impulsive control). Well-posedness results and regularity of the associated propagators follow from classical theory from Kato. As a byproduct, one obtains a topological obstruction to exact controllability of the system in the spirit of the results of Ball, Marsden and Slemrod.
Professional vision of Grade 1 teachers experiencing different levels of work-related stress
2022
This study explored teachers' professional vision by examining how teachers experiencing low, moderate and high work-related stress reason their eye-tracking recordings in terms of description, explanation and prediction. A qualitative analysis of retrospective think-aloud interviews with 24 Grade 1 teachers showed that teachers predominantly used description in their reasoning, while explanation and prediction were less frequent. The description mainly focused on teacher information/elaboration and classroom management/behaviour. Teachers with moderate stress utilised self-reflection most frequently, whereas teachers with high stress utilised it the least. The results suggest that the leve…
Development and validation of a micellar liquid chromatographic method to determine three antitumorals in plasma
2017
Aim: A micellar liquid chromatographic method to determine several anticancer drugs (pazopanib, dabrafenib and regorafenib) in plasma was developed and validated by the guidelines of the EMA. Experimental: Plasma samples were directly injected, after a 1/5-dilution in a micellar solution. The drugs were resolved in <18 min using a C18 column. The mobile phase was an aqueous solution of 0.12 M SDS – 2% 1-pentanol, buffered at pH 7. The detection was performed by absorbance at 260 nm. Results: The values of the main validation parameters were: LOD (0.1–1 mg/l), calibration range (0.2–2 to 80 mg/l), accuracy (-12.5 to +11.7%) and precision (<11.9%). Conclusion: The procedure was conduct…
Permeability and toxicological profile estimation of organochlorine compounds by biopartitioning micellar chromatography
2008
This paper points out the usefulness of biopartitioning micellar chromatography (BMC) as a high-throughput primary screening tool providing key information about the oral absorption, skin permeability (Kp), brain–blood distribution coefficient (BB) and ecotoxicological parameters such as median lethal concentration (LC50) and bioconcentration factors of 15 organochloride compounds. The retention data of compounds in BMC conditions were interpolated in previously developed quantitative–retention activity relationships by our research group. Results show that the compounds studied readily cross the intestinal barrier (oral absorption >ercnt;) and the blood–brain barrier (log BB >p;0.4). In ad…
THE RECOVERY-ELISA—A NOVEL ASSAY TECHNIQUE TO MONITOR THERAPY WITH HUMANIZED ANTIBODIES: THE EXAMPLE OF OMALIZUMAB
2013
The therapeutic use of antibodies has grown exponentially, providing new treatment options for various diseases. Monitoring treatment with therapeutic antibodies is a particular challenge because often the target antigen is no longer measurable or the results are unreliable. To overcome this problem, a recovery-ELISA was developed to quantify therapeutic antibody and antigen by a modification of the traditional sandwich immunoassay using omalizumab as an example. Standard serum samples were spiked with IgE and omalizumab in a certain concentration range to create standard curves. After incubation and washout procedures, the reaction was stopped and the plate read with bichromatic absorbance…
Novel Immunologic Approaches to Melanoma Treatment
2017
Approaches to treating melanoma have changed radically since the introduction of immunotherapy, and survival figures are now higher than possible with earlier therapies. The immunomodulators currently available mainly block CTLA-4 (cytotoxicT lymphocyte-associated molecule-4) and PD-1 (programed cell death protein 1) translocated to the cell surface, where they inhibit the antitumor immune response. Treatments blocking these molecules are being more widely used. Research now seeks new molecular targets, the best combinations of available drugs, and biomarkers that can identify ideal candidates for each one.
Intraoperative transfusion practices and perioperative outcome in the European elderly: A secondary analysis of the observational ETPOS study
2022
PLOS ONE 17(1), e0262110 (2022). doi:10.1371/journal.pone.0262110